Results 1 to 10 of about 4,048 (209)

A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase. [PDF]

PLoS ONE, 2014
Uroporphyrinogen decarboxylase (UROD) catalyzes the conversion of uroporphyrinogen to coproporphyrinogen during heme biosynthesis. This enzyme was recently identified as a potential anticancer target; its inhibition leads to an increase in reactive ...
Kenneth W Yip, Zhan Zhang, Noriko Sakemura-Nakatsugawa, Jui-Wen Huang, Nhu Mai Vu, Yi-Kun Chiang, Chih-Lung Lin, Jennifer Y Y Kwan, Shijun Yue, Yulia Jitkova, Terence To, Payam Zahedi, Emil F Pai, Aaron D Schimmer, Jonathan F Lovell, Jonathan L Sessler, Fei-Fei Liu   +16 more
doaj   +6 more sources

Sporadic Porphyria Cutanea Tarda, Cutaneous Sarcoidosis, and Compound Heterozygosity of HFE Mutations Cys282Tyr and His63Asp—A Case Report [PDF]

eJHaem
Porphyria cutanea tarda (PCT) is caused by inherited or acquired defects of uroporphyrinogen decarboxylase (UROD) in the heme biosynthetic pathway. Altered iron homeostasis via hemochromatosis gene (HFE) mutations is one of many susceptibility factors ...
Jowon L. Kim, Richard Crawford, Ian Marie Lano, Hayley Merkeley   +3 more
doaj   +3 more sources

Uroporphyrinogen decarboxylase as a potential target for specific components of traditional Chinese medicine: a virtual screening and molecular dynamics study. [PDF]

PLoS ONE, 2012
Uroporphyrinogen decarboxylase (UROD) has been suggested as a protectant against radiation for head and neck cancer (HNC). In this study, we employed traditional Chinese medicine (TCM) compounds from TCM Database@Taiwan (http://tcm.cmu.edu.tw/) to screen
Yung-An Tsou, Kuan-Chung Chen, Hung-Che Lin, Su-Sen Chang, Calvin Yu-Chian Chen   +4 more
doaj   +4 more sources

The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposes rats to the development of porphyria and accelerates xenobiotic-triggered porphyria, regardless of hepatic damage [PDF]

Brazilian Journal of Medical and Biological Research, 2002
We evaluated the porphyrinogenic ability of ethanol (20% in drinking water) per se, its effect on the development of sporadic porphyria cutanea tarda induced by hexachlorobenzene in female Wistar rats (170-190 g, N = 8/group), and the relationship with ...
M.C. Ríos de Molina, M.B. Mazzetti, M. Galigniana, C. Aldonatti, J.M. Tomio, L.C. San Martín de Viale   +5 more
doaj   +2 more sources

Comparative genomics of an endophytic Pseudomonas putida isolated from mango orchard [PDF]

Genetics and Molecular Biology, 2016
We analyzed the genome sequence of an endophytic bacterial strain Pseudomonas putida TJI51 isolated from mango bark tissues. Next generation DNA sequencing and short read de novo assembly generated the 5,805,096 bp draft genome of P. putida TJI51. Out of
Huma Asif, David J. Studholme, Asifullah Khan, M. Aurongzeb, Ishtiaq A. Khan, M. Kamran Azim   +5 more
doaj   +2 more sources

Precipitating factors of porphyria cutanea tarda in Brazil with emphasis on hemochromatosis gene (HFE) mutations. Study of 60 patients [PDF]

Anais Brasileiros de Dermatologia, 2013
BACKGROUND: Porphyria cutanea tarda is the most common form of porphyria, characterized by the decreased activity of the uroporphyrinogen decarboxylase enzyme.
Fatima Mendonca Jorge Vieira, Maria Cristina Nakhle, Clarice Pires Abrantes-Lemos, Eduardo Luiz Rachid Cancado, Vitor Manoel Silva dos Reis   +4 more
doaj   +3 more sources

Characterization of a new mutation (R292G) and a deletion at the human uroporphyrinogen decarboxylase locus in two patients with hepatoerythropoietic porphyria [PDF]

, 1992
A deficiency in the activity of uroporphyrinogen decarboxylase (UROD), the fifth enzyme of the haem biosynthetic pathway, is found in familial porphyria cutanea tarda (F-PCT) and hepatoerythropoietic porphyria (HEP). A new mutation (R292G) and a deletion
Bourgeois, F. (Francine), Grandchamp, B. (Bernard), Nordmann, Y. (Yves), Rooij, F.W.M. (Felix) de, Siersema, P.D. (Peter), Verneuil1, H. (Hubert) de, Wilson, J.H.P. (Paul)   +6 more
core   +3 more sources

Porphyria cutanea tarda and systemic lupus erythematosus: a case report [PDF]

Journal of Medical Case Reports
Background Systemic lupus erythematosus is characterized by multiorgan involvement and the presence of autoantibodies. Porphyria cutanea tarda is a condition that affects the liver and skin by downregulating and inhibiting the enzyme uroporphyrinogen ...
Jairo Cajamarca-Baron, Juan Sebastian Bonilla Crespo, Angie Tatiana Calderón Vásquez, Adwar Peña Peña, Julian M. Moreno, Lina Patricia Vargas   +5 more
doaj   +2 more sources

Targeting uroporphyrinogen decarboxylase for head and neck cancer treatment [PDF]

BMC Proc, 2013
Ito E, Yue S, Moriyama E, Hui A, Kim I, Shi W, Alajez N, Bhogal N, Li G, Datti A, Schimmer A, Wilson B, Liu P, Durocher D, Neel B, O’Sullivan B, Cummings B, Bristow R, Wrana J, Liu F.   +19 more
europepmc   +3 more sources

Direct assay of enzymes in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry. Uroporphyrinogen decarboxylase and coproporphyrinogen III oxidase. [PDF]

Anal Chem, 2008
Wang Y, Gatti P, Sadílek M, Scott CR, Turecek F, Gelb MH.   +5 more
europepmc   +2 more sources