Results 1 to 10 of about 1,600 (153)

HK2-driven histone H3K18 lactylation promotes stromal cell senescence and decidualization deficiency in URSA via CUX1-mediated SASP factor transcription [PDF]

Cellular & Molecular Biology Letters
Background Unexplained recurrent spontaneous abortion (URSA) is characterized by defective endometrial stromal cell decidualization, with cellular senescence emerging as a key contributor.
Xiaoxuan Zhao, Yang Zhao, Yuepeng Jiang, Yiming Ma, Jing Ma, Hongli Zhao, Xiaoling Feng   +6 more
doaj   +2 more sources

Hypoxia-driven circ-TBC1D1/miR-520h/EPHB4 impairs trophoblast function in unexplained recurrent spontaneous abortion [PDF]

Scientific Reports
Hypoxia during early pregnancy critically regulates trophoblast function, and its dysregulation has been implicated in unexplained recurrent spontaneous abortion (URSA).
Rong Hua, Qinshan Xie, Jiaxu Li, Yi Mo, Xiu Lin, Chun Huang, Min He, Fengqiong Liu, Yujie Huang, Jiangfan Wan, Yan Sun   +10 more
doaj   +2 more sources

AMPK-mTOR pathway modulates glycolysis reprogramming in unexplained recurrent spontaneous abortion [PDF]

BMC Pregnancy and Childbirth
Background Recurrent spontaneous abortion (RSA), whose underlying cause has yet to be fully elucidated, is often classified as unexplained recurrent spontaneous abortion (URSA).
Yihong Chen, Bei Gan, Shan Zheng, Xiumei Zhao, Leiyi Jin, Juanbing Wei   +5 more
doaj   +2 more sources

Network connectivity between partner factors, loneliness, and psychological distress in women with unexplained recurrent spontaneous abortion [PDF]

BMC Pregnancy and Childbirth
Background Women experienced unexplained recurrent spontaneous abortion (URSA) are at higher risk of depression, anxiety, and other psychological disorders.
Zhongxuan Huang, Hang Xu, Yizhao Chen, Xingming Zhong, Fan Zhang   +4 more
doaj   +2 more sources

Decidual stromal cells-derived exosomes incured insufficient migration and invasion of trophoblast because of abnormal ubiquitination and degradation of Snail mediated by miR-92b-3p/USP28 [PDF]

BMC Biology
Background Recent findings have demonstrated that inadequate trophoblast migration and invasion are often responsible for the unsuccessful communication between the mother and fetus, contributing to URSA (unexplained recurrent spontaneous abortion ...
Miao Xiong, Ziqiu He, Liping Wen, Aimin Zhao   +3 more
doaj   +2 more sources

Metabolomics and proteomics analyses reveal the role of the glycerophospholipid metabolism pathway in unexplained recurrent spontaneous abortion [PDF]

PeerJ
Background Unexplained recurrent spontaneous abortion (URSA) is a complex pregnancy complication with a high miscarriage rate. Incomprehensive understanding of the molecular mechanism in URSA also leads to a lack of effective treatment methods.
Yihong Chen, Xiumei Zhao, Bei Gan, Leiyi Jin, Juanbing Wei, Jianying Yan   +5 more
doaj   +3 more sources

Deciphering N7-methylguanosine-driven immune dysregulation in unexplained recurrent spontaneous abortion based on transcriptome data and experimental validation [PDF]

European Journal of Medical Research
Background Unexplained recurrent spontaneous abortion (URSA) poses significant clinical challenges, with immune dysregulation at the maternal–fetal interface implicated in 80% of cases.
Qing Guo, Shimeng Wang, Sujie Song, Xiaoxuan Zhao   +3 more
doaj   +2 more sources

Gut microbiota-derived metabolites associate with circulating immune cell subsets in unexplained recurrent spontaneous abortion [PDF]

Heliyon
Currently, the precise causes of over 40 % of recurrent spontaneous abortion (RSA) cases cannot be identified, leading to the term “unexplained RSA” (URSA).
Zhi Li, Yongquan Zheng, Meng Zhang, Kaiqi Wu, Long Zhang, Yao Yao, Caihong Zheng   +6 more
doaj   +2 more sources

Efficacy of mesenchymal stromal cells in the treatment of unexplained recurrent spontaneous abortion in mice: An analytical and systematic review of meta-analyses. [PDF]

PLoS ONE, 2023
ObjectivesUnexplained recurrent spontaneous abortion (URSA) remains an intractable reproductive dilemma due to the lack of understanding of the pathogenesis.
Xiaoxuan Zhao, Yijie Hu, Wenjun Xiao, Yiming Ma, Dan Shen, Yuepeng Jiang, Yi Shen, Suxia Wang, Jing Ma   +8 more
doaj   +2 more sources

Daphnetin alleviates unexplained recurrent spontaneous abortion by regulating the NR4A1/BACH2 axis in mice [PDF]

Biological Research
Background Daphnetin has demonstrated various pharmacological activities. The current study evaluated the potential of daphnetin in alleviating unexplained recurrent spontaneous abortion (URSA) and explored underlying mechanisms.
Zhiqin Zhang, Jun Tan, Xingwu Wu, Xin Li, Peipei Liu, Liyun Cao, Shenggen Long   +6 more
doaj   +2 more sources