Results 121 to 130 of about 119,123 (311)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
UTILISING IGV APPROACH TO IDENTIFY FACTORS AFFECTING WEB USABILITY
Journal of ICT, 2003 Due to the changing nature of Internet technology and user needs, continuous web evaluation has become very important in determining the usability of web sites.
Shahizan Hassan, Feng Li
doaj
PUMA Footprints: linking theory and craft skill in usability evaluation
, 2001 ‘Footprints’ are marks or features of a design that alert the analyst to the possible existence of usability difficulties caused by violations of design principles. PUMA Footprints make an explicit link between the theory underlying a Programmable User
Curzon, P. +2 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Evaluation of Virtual Teaching-Learning Environments based on usability standards
TecnoLógicas, 2018 The main objective of this review article is to determine the necessary sub-characteristics or aspects for the evaluation of Virtual Teaching-Learning Environments (VTLEs) as final or finished products based on ISO 9126, 14598 and 25000-SQuaRE standards.
Jose I. Cocunubo-Suarez +2 more
doaj
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A heuristic evaluation of the Facebook's advertising tool beacon
, 2009 Interface usability is critical to the successful adoption of information systems. The aim of this study is to evaluate interface of Facebook's advertising tool Beacon by using privacy heuristics [4].
Jamal, A +3 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Usability engineering for GIS: learning from a screenshot
, 2007 In this paper, the focus is on the concept of Usability Engineering for GIS – a set of techniques and methods that are especially suitable for evaluating the usability of GIS applications – which can be deployed as part of the development process.
Zafiri, A.F. +4 more
core
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source