Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Guerra in Ucraina: tra diritto internazionale e prospettive culturali
Aequitas MagazineThis article offers an integrated legal and cultural analysis of the Russian aggression against Ukraine, combining the doctrinal framework of international law with the deeper historical, symbolic and identity-based dynamics that have shaped the Kremlin ...
Luigi Zito
doaj +1 more source
Use of force-velocity relationship to estimate the one-repetition maximum leg press exercise among young females. [PDF]
J Phys Ther Sci, 2023 Kurobe Y, Momose K.
europepmc +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
A contextualized assessment of duty-related bodily harm associated with Canadian police services
FACETSCanadian police report substantially more mental health challenges than the general population, partially due to negative media coverage. Negative media coverage often focuses on critiquing police causing duty-related bodily harm (DRBH) without ...
R.N. Carleton +4 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Управленческое консультирование, 2018 This article explores the problem addressing the political and legal rationale of the “humanitarian intervention”. The right to perform “humanitarian intervention” is to be derived from moral obligations, and presumed as a resume of the universally ...
Stanislav Valentinovich Korostelev
doaj
Individuals with and without Visual Impairments Use a Force Feedback Device to Identify the Friction and Hardness of Haptic Surfaces. [PDF]
Sensors (Basel), 2022 Papadopoulos K +3 more
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Use the force, fluke: Ligand-independent gating of Schistosoma mansoni ion channel TRPM<sub>PZQ</sub>. [PDF]
Int J Parasitol, 2023 Chulkov EG +3 more
europepmc +1 more source