Results 71 to 80 of about 166,285,658 (247)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Reconsidering the Consequences for State-Sponsored Hostile Cyber Operations Under International Law
The Cyber Defense Review, 2018 In 2012, then-Secretary of Defense Leon Panetta spoke about the rising dangers of a “cyber Pearl Harbor,” analogizing the potential devastation from a cyberattack to that of the surprise attack on the U.S. naval base in Hawaii in December of 1941.
Catherine Lotrionte
doaj +1 more source
Examining Violent Police-Citizen Encounters in South Africa: A Focus on Suspect and Police Behaviour [PDF]
E-Journal of Humanities, Arts and Social SciencesNumerous grievances have been lodged against police officers who abused their mandate to use force, which is a matter that has raised serious concern not only in policing circles but in the media as well.
Philisiwe Hadebe
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
, 2014 The quarterly newsletter, The Ninth Flyer, published by the Ninth Air Force Association, Inc.
9th Air Force Association
core +1 more source
THE EXPANDING USE OF DRONES IN GOVERNMENT OPERATIONS [PDF]
Challenges of the Knowledge SocietyThe rapid advancement of unmanned vehicle technology has significantly expanded the use of drones in government agency operations worldwide. This paper examines how public institutions increasingly integrate drones to enhance efficiency, accuracy, and ...
Andrei-Alexandru STOICA
doaj
Управленческое консультирование, 2018 In any specific case of the use of armed violence, the question of its legitimation arises, that is, the need to justify the validity of an act of use of force in the language of the law.
S. V. Korostelev
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 1983 This paper describes the Air Force's facility energy management program including how industry can help the Air Force meet its facility energy objectives.
Holden, P. C., Kroop, R. H.
core