Results 91 to 100 of about 507,808 (266)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Network Analysis of Association Between Problematic Social Network Use and Alexithymia in Freshmen

Psychology Research and Behavior Management
Ling Ding,1 Xuelian Ren,2 Yamei Sun,3 Chengjuan Yu,1 Ge Li,1 Chenggang Wang1 1School of Health, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 2Office of Academic Affairs, Heze University, Heze, Shandong,
Ding L, Ren X, Sun Y, Yu C, Li G, Wang C
doaj  

Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada.

PLoS ONE, 2019
BACKGROUND:The structure of a social network as well as peer behaviours are thought to affect personal substance use. Where substance use may create health risks, understanding the contribution of social networks to substance use may be valuable for the ...
Verena Knerich, Andrea A Jones, Sam Seyedin, Christopher Siu, Louie Dinh, Sara Mostafavi, Alasdair M Barr, William J Panenka, Allen E Thornton, William G Honer, Alexander R Rutherford   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Wildlife hunting and the increased risk of leprosy transmission in the tropical Americas: a pathogeographical study

Infectious Diseases of Poverty
Background Leprosy remains a persistent public health challenge, where human-to-human transmission of Mycobacterium leprae via respiratory droplets is well established.
Alisa Aliaga-Samanez, Patricia D. Deps, Julia E. Fa, Raimundo Real, Jean-François Guégan, Marcela A. Oliveira, Aline Pessutti, Simon Knoop, Juliano A. Bogoni, Thais Q. Morcatty, Roberta Marques, Daniel Jiménez-García, Gabriel F. Massocato, Arnaud L. Desbiez, Danilo Kluyber, Hani R. El Bizri   +15 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The use of social networks in a Virtual University

, 2019
ESP
León Gómez, Alicia, Calderón Garrido, Diego, Gil Fernández, Raquel   +2 more
openaire   +2 more sources

The impact of social network use on adolescent depression: the chain mediation between self-objectification and body satisfaction

Frontiers in Psychology
IntroductionAdolescents are in the transitional stage from childhood to adulthood, a critical period for individual physical and mental development. With the rapid development of the Internet, social networking has become an integral part of adolescents’
Yiming Tang, Min Xu, Zhongwei Tan, Yong Liu, Yong Liu   +4 more
doaj   +1 more source

Influence of social network on drug use among clients of methadone maintenance treatment centers in Kunming, China.

PLoS ONE, 2018
AimsTo examine drug use behavior of clients attending Methadone Maintenance Treatment (MMT) programs and its relationship with the clients' social network characteristics.DesignCross-sectional study.SettingFour MMT clinics in Kunming, Yunnan province ...
Ling Shen, Sawitri Assanangkornchai, Wei Liu, Le Cai, Fei Li, Songyuan Tang, Jiucheng Shen, Edward B McNeil, Virasakdi Chongsuvivatwong   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source