Results 81 to 90 of about 2,999,855 (295)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Co-producing a peer-led health conversation tool for the health services workforce to facilitate safer use of anabolic–androgenic steroids

Harm Reduction Journal
Background Illicit anabolic–androgenic steroid (AAS) use poses physical and psychosocial risks. These issues are exacerbated by inadequate public health responses and well-meaning yet inadequately trained health workers.
Timothy Piatkowski, Sonya Weith, Emma Kill, Brooke Walters, Geoff Davey, Cameron Francis, Steph Reeve, Ross Coomber, Jason Ferris, Monica Barratt, Cheneal Puljevic, Emily Stockings   +11 more
doaj   +1 more source

Image Labeling on a Network: Using Social-Network Metadata for Image Classification [PDF]

, 2012
Large-scale image retrieval benchmarks invariably consist of images from the Web. Many of these benchmarks are derived from online photo sharing networks, like Flickr, which in addition to hosting images also provide a highly interactive social community.
Julian Mcauley, Jure Leskovec, Y Yc
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

THE USE OF SOCIAL NETWORK THEORY ON ENTREPRENEUR’S LINKAGES DEVELOPMENT [PDF]

To embark on any housing project, a developer needs to have support from various parties. The housing and construction industries are interrelated; they are in a relationship where construction plays a major part in the development process.
Abdul-Rashid ABDUL-AZIZ, Mastura JAAFAR, Muhammad-Hijas SAHARI   +2 more
core  

The Management and Use of Social Network Sites in a Government Department

, 2011
In this paper we report findings from a study of social network site use in a UK Government department. We have investigated this from a managerial, organisational perspective.
A Fu, AE McAfee, D Boyd, D Osimo, D Schuler, EC Page, G Button, Ian Sommerville, JB Smith, John Rooksby, M McGovern, TW Malone, W Eggers   +12 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Development and Psychometric Properties of the Social Network Site Use Motives Scale–Revised

Psychiatry and Clinical Psychopharmacology, 2023
Young-Jin Lim
doaj   +1 more source

Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada.

PLoS ONE, 2019
BACKGROUND:The structure of a social network as well as peer behaviours are thought to affect personal substance use. Where substance use may create health risks, understanding the contribution of social networks to substance use may be valuable for the ...
Verena Knerich, Andrea A Jones, Sam Seyedin, Christopher Siu, Louie Dinh, Sara Mostafavi, Alasdair M Barr, William J Panenka, Allen E Thornton, William G Honer, Alexander R Rutherford   +10 more
doaj   +1 more source