Results 81 to 90 of about 506,711 (266)

Co-producing a peer-led health conversation tool for the health services workforce to facilitate safer use of anabolic–androgenic steroids

Harm Reduction Journal
Background Illicit anabolic–androgenic steroid (AAS) use poses physical and psychosocial risks. These issues are exacerbated by inadequate public health responses and well-meaning yet inadequately trained health workers.
Timothy Piatkowski, Sonya Weith, Emma Kill, Brooke Walters, Geoff Davey, Cameron Francis, Steph Reeve, Ross Coomber, Jason Ferris, Monica Barratt, Cheneal Puljevic, Emily Stockings   +11 more
doaj   +1 more source

The impact of social network use on adolescent depression: the chain mediation between self-objectification and body satisfaction

Frontiers in Psychology
IntroductionAdolescents are in the transitional stage from childhood to adulthood, a critical period for individual physical and mental development. With the rapid development of the Internet, social networking has become an integral part of adolescents’
Yiming Tang, Min Xu, Zhongwei Tan, Yong Liu, Yong Liu   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Network Analysis of Association Between Problematic Social Network Use and Alexithymia in Freshmen

Psychology Research and Behavior Management
Ling Ding,1 Xuelian Ren,2 Yamei Sun,3 Chengjuan Yu,1 Ge Li,1 Chenggang Wang1 1School of Health, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 2Office of Academic Affairs, Heze University, Heze, Shandong,
Ding L, Ren X, Sun Y, Yu C, Li G, Wang C
doaj  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Wildlife hunting and the increased risk of leprosy transmission in the tropical Americas: a pathogeographical study

Infectious Diseases of Poverty
Background Leprosy remains a persistent public health challenge, where human-to-human transmission of Mycobacterium leprae via respiratory droplets is well established.
Alisa Aliaga-Samanez, Patricia D. Deps, Julia E. Fa, Raimundo Real, Jean-François Guégan, Marcela A. Oliveira, Aline Pessutti, Simon Knoop, Juliano A. Bogoni, Thais Q. Morcatty, Roberta Marques, Daniel Jiménez-García, Gabriel F. Massocato, Arnaud L. Desbiez, Danilo Kluyber, Hani R. El Bizri   +15 more
doaj   +1 more source

Influence of social network on drug use among clients of methadone maintenance treatment centers in Kunming, China.

PLoS ONE, 2018
AimsTo examine drug use behavior of clients attending Methadone Maintenance Treatment (MMT) programs and its relationship with the clients' social network characteristics.DesignCross-sectional study.SettingFour MMT clinics in Kunming, Yunnan province ...
Ling Shen, Sawitri Assanangkornchai, Wei Liu, Le Cai, Fei Li, Songyuan Tang, Jiucheng Shen, Edward B McNeil, Virasakdi Chongsuvivatwong   +8 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Discussion Network Heterogeneity Matters: Examining a Moderated Mediation Model of Social Media Use and Civic Engagement

International Journal of Communication, 2015
Employing original two-wave national panel survey data, this study examines the mediating role of discussion network heterogeneity on social media in the relationship between social media use for news/information and civic engagement.
Yonghwan Kim, Hsuan-Ting Chen
doaj