Results 121 to 130 of about 515,612 (281)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Making Exhibitions, Brokering Meaning: Designing new connections across communities of practice [PDF]

open access: yes, 2008
New media museum exhibits often see designers representing the research of expert content providers. Despite perceptions that such exhibits provide museum visitors with a greater depth and range of experience, differences in knowledge and practice ...
Barnes, Carolyn, Kocsis, Anita
core   +1 more source

Guidelines Towards Better Participation of Older Adults in Software Development Processes using a new SPIRAL Method and Participatory Approach

open access: yes, 2018
This paper presents a new method of engaging older participants in the process of application and IT solutions development for older adults for emerging IT and tech startups.
Aula Anne   +5 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Developing a Neuroarchitecture-based User Centered Design for Elementary Schools in Tehran

open access: yesAin Shams Engineering Journal
Neuroarchitecture research investigates how environmental design affects the nervous system using quantitative methods. However, for user-centered design, qualitative research is equally important to actively involve users in the design process.
Beheshteh Gharaei   +2 more
doaj   +1 more source

User-Centered Comparison of Web Search Tools [PDF]

open access: yes, 2005
This study explores a user-centered approach to the comparative evaluation of the Web search tool ProThes against popular all-purpose search engines Yandex and Google. An original research design was developed.
Braslavski, P.   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

User centered passive building design [PDF]

open access: yes, 2013
The full integration of End User Factors (EUFs) into the building design processes environment is still emergent. It has been suggested from other sectors that the integration of EUFs into design can improve work performance and promote the workforce’s physical and mental health.
openaire   +1 more source

A Hands-On, Active Learning Approach to Increasing Manufacturing Knowledge in Engineering Students [PDF]

open access: yes, 2013
This paper describes a new learning module implemented as part of the senior capstone design course at Marquette University to teach engineering students about basic manufacturing processes, lean manufacturing principles, and design for manufacturability.
Goldberg, Jay R., Rank, David B.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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