Results 121 to 130 of about 1,150,410 (270)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

User-Centered Delivery of AI-Powered Health Care Technologies in Clinical Settings: Mixed Methods Case Study

JMIR Human Factors
BackgroundProviders spend a large percentage of their day using electronic health record (EHR) technology and frequently report frustration when EHR tasks are time-consuming and effortful.
Meredith Schreier, Randall Brandt, Hien Brown, T Saensuksopa, Christine Silva, Laura M Vardoulakis   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Innovative design and evaluation of medical nebulizer for preschool children: A user demand-driven approach.

PLoS ONE
AimsTo enhance the user experience and satisfaction of children's medical nebulizers, and to improve adherence and the efficacy of nebulization treatments for children, this study explores an innovative design and evaluation method for children's medical
YanXiao Zhao, Tao Wang, LiMing Zhang, Basyarah Hamat, Leah Ling Li Pang   +4 more
doaj   +1 more source

The Real Time Display Builder (RTDB) [PDF]

The Real Time Display Builder (RTDB) is a prototype interactive graphics tool that builds logic-driven displays. These displays reflect current system status, implement fault detection algorithms in real time, and incorporate the operational knowledge of
Bailey, Samuel A., Jr., Kindred, Erick D.   +1 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Generative design for architectural spatial layouts: a review of technical approaches

Journal of Asian Architecture and Building Engineering
The design of spatial layouts is a classic challenge in architectural design. This study reviews the current research on generative design for architectural spatial layouts, focusing mainly on technological methodologies.
Shurui Yan, Chen Wu, Yixin Zhang
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Optimizing Urban Public Transportation with a Crowding-Aware Multimodal Trip Recommendation System

Smart Cities
Traditional multimodal public transportation recommenders often overlook in-vehicle crowding, a critical factor that causes passenger discomfort and leads to an inefficient distribution of people across the network that affects its reliability.
Assunta De Caro, Ida Falco, Angelo Furno, Eugenio Zimeo   +3 more
doaj   +1 more source