Results 61 to 70 of about 88,476 (300)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Consumption Trends During the COVID-19 Crisis: How Awe, Coping, and Social Norms Drive Utilitarian Purchases

Frontiers in Psychology, 2020
As the coronavirus disease 2019 (COVID-19) crisis continues to worsen globally, there exists a widespread enthusiasm for buying utilitarian products in the retail market, irrespective of culture or nationality.
Yikai Yang, Yikai Yang, Ou Li, Ou Li, Xixian Peng, Xixian Peng, Lei Wang, Lei Wang   +7 more
doaj   +1 more source

Favoritism Toward Foreign and Domestic Brands: A Comparison of Different Theoretical Explanations [PDF]

, 2019
Five theoretical approaches can predict favoritism toward domestic and foreign brands. This article applies a contrastive perspective to examine social identity, personal identity, cultural identity, system justification, and categorical cognition ...
Anastasia Stathopoulou, George Balabanis, Jiayu Qiao, Khan Uzma, Magnusson Peter, Micevski Milena, Muthén Linda K., Samiee Saeed, Shavitt Sharon, Tajfel Henri, Tourangeau Roger, Turner John C., Zhang Yinlong   +12 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Utilitarianism and unequal longevities: A remedy? [PDF]

Classical utilitarianism, if coupled with standard assumptions such as the expected utility hypothesis and additive lifetime welfare, has the undesirable corollary to recommend a redistribution of resources from short-lived to long-lived agents, against ...
Grégory Ponthière, Marie-Louise Leroux
core   +3 more sources

Generation Z's appetite for traditional food: unveiling the interplay of sustainability values as higher order construct and food influencers in Indonesia

Discover Sustainability
Promoting traditional food consumption has the potential to accelerate the achievement of sustainable goals since these foods are generally produced with natural local ingredients, are affordable and widely available, support local economies, and suit ...
Kristia Kristia, Sándor Kovács, László Erdey   +2 more
doaj   +1 more source

THE OPTIMAL DEPLETION OF EXHAUSTIBLE RESOURCES: A COMPLETE CHARACTERIZATION [PDF]

We provide the closed form solution to the Dasgupta-Heal-Solow-Stiglitz (DHSS) model. The DHSS model is based on the seminal articles Dasgupta and Heal (Rev. Econ. Stud., 1974), Solow (Rev. Econ. Stud., 1974) and Stiglitz (Rev. Econ.
Cees Withagen, Hassan Benchekroun
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

GLOBAL DYNAMICS IN A GROWTH MODEL WITH AN EXHAUSTIBLE RESOURCE [PDF]

We revisit the seminal growth model with exhaustible resources, the so called Dasgupta-Heal-Stiglitz-Solow model (DHSS). For this optimal control problem with two state variables, we explicitly characterize the dynamics of all the variables in the model ...
Cees Withagen, Hassan Benchekroun
core