Results 91 to 100 of about 188,183 (294)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Utilitarian or Hedonic? A Cross Cultural Study in Online Shopping

Organizations and Markets in Emerging Economies, 2018
With the irreversible effect of globalization, a growing number of websites today sell their products to more than one country. The effects of cross cultural differences on buying behaviors are widely acknowledged.
Hilal Ozen, Nil Kodaz
doaj   +1 more source

Conservation Value [PDF]

, 2010
This paper outlines the significance of the concept of conservation value and discusses ways in which it is determined paying attention to views stemming from utilitarian ethics and from deontological ethics.
Tisdell, Clem
core  

Priority for the Worse Off and the Social Cost of Carbon [PDF]

, 2016
The social cost of carbon (SCC) is a monetary measure of the harms from carbon emission. Specifically, it is the reduction in current consumption that produces a loss in social welfare equivalent to that caused by the emission of a ton of CO2.
A Millner, A Williams, AC Pigou, B Tungodden, C Blackorby, C Brown, C Gollier, C Kolstad, D Anthoff, D Parfit, D Parfit, DM Kreps, EA Stanton, F Dennig, FA Cowell, FHG Ferreira, FP Ramsey, GG Szpiro, J Broome, J Broome, J Cockburn, J Quiggin, J Rawls, JA Mirrlees, JA Weymark, JCJM van den Bergh, JCJM van den Bergh, KJ Arrow, L Kaplow, LG Epstein, M Drupp, M Fleurbaey, M Greenstone, MD Adler, MD Adler, MD Adler, MK Brunnermeier, ML Weitzman, N Holtug, N Holtug, N Stern, N Stern, O Johansson-Stenman, OP Attanasio, P Dasgupta, P-A Chiappori, PA Samuelson, R Boadway, R Chetty, RF Harrod, RM Solow, RS Pindyck, RS Tol, RW Boadway, S Anand, S Dietz, T Porter, W Bossert, W Pizer, WD Nordhaus, WD Nordhaus, WD Nordhaus, WD Nordhaus, WJW Botzen   +63 more
core   +4 more sources

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A benefit congruency framework of sales promotion effectiveness [PDF]

Are monetary savings the only explanation for consumer response to a sales promotion ? If not, how do the different consumer benefits of a sales promotion influence its effectiveness ?
CHANDON, Pierre, LAURENT, Gilles, WANSINK, Brian   +2 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Turkish Users’ Continuance Intention to Use Mobile Fitness Apps: The Roles of Utilitarian Value and Hedonic Value

Pamukkale Spor Bilimleri Dergisi
The purpose of this research is to elucidate the primary factors influencing users' continuance intention (COIN) of mobile fitness apps, with a focus on three utilitarian variables (perceived service quality [QUAL], monetary value [MVAL], convenience ...
Görkem Erdoğan
doaj   +1 more source

Temporal variations of bicycle demand in the Netherlands: The influence of weather on cycling [PDF]

, 2009
The variability in bicycle demand depends strongly on weather. This paper describes a ‘weather’ model that makes demand forecasting possible. The model is based on flow time-series of many years, collected at 16 cycle paths in the Dutch cities of Gouda ...
Jaarsma, C.F., Thomas, T., Tutert, S.I.A.   +2 more
core   +1 more source