Results 101 to 110 of about 1,355,209 (298)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
A combined approach of nature-inspired Firefly Algorithm and Weighted Principal Component Analysis in machining of Inconel X-750 [PDF]
FME Transactions, 2020 Electrical discharge machining (EDM) is the primary unconventional machining process used for very hard conductive materials. Inconel-750 is used in various high-performance applications like aerospace, automobiles, etc.
Pandey Som Nath +3 more
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Compromises Between Cardinality and Ordinality in Preference Theory and Social Choice [PDF]
By taking sets of utility functions as a primitive description of agents, we define an ordering over assumptions on utility functions that gauges their implicit measurement requirements.
Michael Mandler
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
On the (non) History of Preference Purification in Modern Economics
Review of the History of Economic Thought and MethodologyEconomists have typically viewed an individual's economic choices as being tightly linked to their preferences, and in turn, their preferences being tightly linked to the welfare associated with those choices.
D. Wade Hands
doaj +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Evolving Coauthorship Modeling and Prediction via Time-Aware Paired Choice Analysis
IEEE Access, 2019 Coauthorship prediction is challenging yet important for academic collaboration and novel research topics discovery. The challenges lie in the dynamics of social or organizational relationships, changing preferences of suitable collaborators, and the ...
Liang Hu +5 more
doaj +1 more source
Risk Aversion and Expected-Utility Theory: A Calibration Theorem [PDF]
Within the expected-utility framework, the only explanation for risk aversion is that the utility function for wealth is concave: A person has lower marginal utility for additional wealth when she is wealthy than when she is poor.
Matthew Rabin
core