Results 71 to 80 of about 1,355,209 (298)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

THE VALUE OF MONEY AND THE FLAW-OF-AVERAGES

South African Journal of Industrial Engineering, 2018
Given the state of uncertainty in the world, decision analysis and decision-making under conditions of uncertainty are becoming more important. However, any rational decision-making requires a criterion on which to base the decision — which implies the ...
Kruger, Paul , Yadavalli, Sarma
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

CIB - UTILITY BASED SYSTEMS FRAMEWORK FOR EXISTING RESIDENTIAL BUILDING

Journal of Asian Architecture and Building Engineering, 2022
This study proposes an approach for conducting comparative assessments between renovation and new construction through the use of CIB utility theory systems and applies the methodology to an adaptive case study. To this end, the theoretical underpinnings
Ching-Chi Lin, Lucky Shin-Jyun Tsaih, Yeng-Horng Perng, Ting-Yi Chiang   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Prospect Theory Goes to War: Loss-Aversion and the Duration of Military Combat [PDF]

, 1997
This paper contributes to the empirical foundation of prospect theory in real-life international relations by testing two of its major implications in the field of military conflict. Using duration analysis for a data set of twentieth century battles, it
Bauer, Thomas, Rotte, Ralph
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Assessing the sustainability of agricultural production - a cross-sectoral comparison of the blackberry, tomato and tree tomato sectors in Ecuador

International Journal of Agricultural Sustainability, 2022
Achieving a sustainable agricultural system requires an effective assessment of economic, environmental, and social conditions. Existing research has mainly focused on a single sector and lacks critical comparisons of determinants and trade-offs between ...
Carlos Moreno-Miranda, Liesbeth Dries
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Utilitarian Decision—Making Approach for Front End Design—A Systematic Literature Review

Buildings, 2020
The complexity of construction processes often means interaction between various stakeholders, activities and tasks in order to deliver the expected outcomes.
Joas Serugga, Mike Kagioglou, Patricia Tzortzopolous   +2 more
doaj   +1 more source