Results 51 to 60 of about 914 (177)

Different Contribution of Missense and Loss‐of‐Function Variants to the Genetic Structure of Familial and Sporadic Meniere Disease

MedComm, Volume 6, Issue 10, October 2025.
This study examines the genetic basis of sporadic (SMD) and familial Meniere disease (FMD) by comparing rare protein‐coding variants using exome sequencing and gene burden analysis. FMD patients had a higher accumulation of missense and LoF variants, especially in genes linked to auditory and vestibular function.
Alberto M. Parra‐Perez, Alvaro Gallego‐Martinez, Alba Escalera‐Balsera, Paula Robles‐Bolivar, Patricia Perez‐Carpena, Jose A. Lopez‐Escamez   +5 more
wiley   +1 more source

Bromelain‐Rich Pineapple Extract for the Treatment of Pediatric Patients With Orchiepididymitis: A Randomized Clinical Pilot Study

Molecular Nutrition &Food Research, Volume 69, Issue 19, October 2025.
From pineapple byproducts to a pharmaceutical formulation. ABSTRACT A freeze‐dried pineapple extract—Brome‐Inf, from pineapple by‐products of industrial rings production, was enriched in bioactive polypeptides and bromelain by membrane ultrafiltration. Orchiepididymitis (OE), a painful pediatric pathology, was treated with this extract. A pilot, double‐
Alessandro Colletti, Luciano Sangiorgio, Alma Martelli, Marzia Pellizzato, Giancarlo Cravotto   +4 more
wiley   +1 more source

Multimodal floral cues resembling both generalized food sources and oviposition sites in Isotrema manshuriense (Aristolochiaceae) pollinated by flies

Plant Biology, Volume 27, Issue 6, Page 1058-1070, October 2025.
The protogynous flowers of Isotrema manshuriense exhibit multimodal cues, resembling both generalized food sources and fly oviposition sites, with these cues varying across sexual phases. Abstract The genus Aristolochia is renowned for its kettle‐like trap flowers that temporarily retain visiting insects, primarily using trapping trichomes.
H. Lim, Y.‐K. Kim, S. Lee, M.‐S. Choi, D. Lee, D. Kim, S. J. Suh, S.‐G. Kim   +7 more
wiley   +1 more source

μVEMP: A Portable Interface to Record Vestibular Evoked Myogenic Potentials (VEMPs) With a Smart Phone or Tablet

Frontiers in Neurology, 2018
Background: Cervical VEMPs and ocular VEMPs are tests for evaluating otolith function in clinical practice. We developed a simple, portable and affordable device to record VEMP responses on patients, named μVEMP.
Hamish G. MacDougall, John Holden, Sally M. Rosengren, Sally M. Rosengren, Elodie Chiarovano   +4 more
doaj   +1 more source

Firing properties of muscle spindle afferents in the intrinsic foot muscles and tactile afferents from the sole of the foot during upright stance

Experimental Physiology, Volume 110, Issue 10, Page 1492-1510, October 1, 2025.
Abstract We review our approach for undertaking microelectrode recordings from the posterior tibial nerve at the ankle, which has allowed us to identify, for the first time, the firing properties of muscle spindle endings in the intrinsic muscles of the foot and of cutaneous mechanoreceptors in the sole during unsupported standing.
Thomas P. Knellwolf, Alex Burton, Elie Hamman, Vaughan G. Macefield   +3 more
wiley   +1 more source

Ageing changes the proprioceptive contribution to balance control under different types of mastoid vibration: A cross‐sectional study

Experimental Physiology, Volume 110, Issue 10, Page 1431-1446, October 1, 2025.
Abstract Ageing‐related sensory deteriorations are significantly associated with poor balance control among older individuals, resulting in a higher risk of falling in a dark environment. In particular, the proprioceptive system plays a critical role in maintaining balance.
Haoyu Xie, Zhuo Wang, Chuhuai Wang, Jung Hung Chien   +3 more
wiley   +1 more source

Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1

eLife, 2019
The mammalian cochlea loses its ability to regenerate new hair cells prior to the onset of hearing. In contrast, the adult vestibular system can produce new hair cells in response to damage, or by reprogramming of supporting cells with the hair cell ...
Hsin-I Jen, Matthew C Hill, Litao Tao, Kuanwei Sheng, Wenjian Cao, Hongyuan Zhang, Haoze V Yu, Juan Llamas, Chenghang Zong, James F Martin, Neil Segil, Andrew K Groves   +11 more
doaj   +1 more source

A Case of Vertical Diplopia after Thalamic Deep Brain Stimulation for Essential Tremor

Movement Disorders Clinical Practice, EarlyView.
Rena Far, Suresh Subramaniam, Camila Aquino, Fady Girgis   +3 more
wiley   +1 more source

Transient capacitance changes recorded from vestibular type I hair cells are produced by GK,L gating and do not involve neurotransmitter exocytosis

The Journal of Physiology, Volume 603, Issue 19, Page 5547-5564, October 1, 2025.
Abstract figure legend Schematic diagrams of mammalian wild type (WT) (A) and Caspr‐KO (B) type‐I vestibular hair cells showing localization of the Caspr protein (orange), the Ca2+ conductance (green) and the low‐voltage‐activated K+ conductance (blue).
Paolo Spaiardi, Roberta Giunta, Giorgio Rispoli, Sergio Masetto, Stuart L. Johnson   +4 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source