Results 91 to 100 of about 43,652 (215)

Clinical descriptive and long‐term outcome of melanocytic uveal lesions in young dogs: 40 cases (45 eyes) including 13 cases of sector iridectomy

Veterinary Ophthalmology, Volume 28, Issue 2, Page 371-385, March 2025.
Abstract Purpose To describe the clinical features surgical technique, early and long‐term outcome with or without surgery, and histopathological findings of melanocytic anterior uveal lesions in young dogs. Methods Medical records of dogs at a guide dog facility removed from training due to a pigmented iris lesion were reviewed from 2014 to 2021 ...
Valerie Liliane Dufour, Julie A. Cohen, Charles‐Antoine Assenmacher, Dolores M. Holle, Amy C. Durham, Gustavo D. Aguirre, Keiko Miyadera   +6 more
wiley   +1 more source

Fucoidan Does Not Exert Anti-Tumorigenic Effects on Uveal Melanoma Cell Lines [PDF]

, 2017
Background. The polysaccharide fucoidan is widely investigated as an anti-cancer agent. Here, we tested the effect of fucoidan on uveal melanoma cell lines. Methods.
Coupland, Sarah E, Dithmer, Michaela, Fuchs, Sabine, Kirsch, Anna-Maria, Klettner, Alexa, Richert, Elisabeth, Roider, Johann, Schmidt, Harald, Wang, Fanlu   +8 more
core   +2 more sources

Use of Transcorneal Iris Photocoagulation to Facilitate Sector Iridectomy of Pigmented Iridal Tumors: A Case Series of Five Eyes (Three Dogs and One Cat)—Clinical Findings, Surgical Technique, Complications, and Outcome

Veterinary Ophthalmology, EarlyView.
ABSTRACT Objective To describe the use of transcorneal iris photocoagulation (TCIP) to improve intraocular visualization of intended incision lines, reduce hemorrhage, and facilitate excision of pigmented iridal tumors in four canine eyes and one feline eye.
A. K. Shukla, P. Grest, N. Holz, A. Rampazzo, S. A. Pot   +4 more
wiley   +1 more source

Current Therapies and Potential Strategies for Uveal Melanoma

Drugs and Drug Candidates
Background/Objectives: Uveal melanoma (UM) is a rare but deadly ocular cancer. This review summarizes the characteristics of uveal melanoma and current therapeutic options for primary uveal melanoma and metastatic uveal melanoma, and introduces recent ...
Sarah Scoles, Sanjay Ganesh, Kaori H. Yamada   +2 more
doaj   +1 more source

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma [PDF]

, 2013
BACKGROUND: Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential.
Agapova, Olga A, Bowcock, Anne M, Harbour, J. William, Matatall, Katie A, Onken, Michael D, Worley, Lori A   +5 more
core   +2 more sources

Intermediate Cell Type Uveal Melanoma [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. [PDF]

, 2009
BRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures, and lead to constitutive activation of the mitogen-activated protein (MAP) kinase pathway.
Barsh, Gregory S, Bastian, Boris C, Bauer, Jürgen, Bezrookove, Vladimir, Gaugler, Lona, Green, Gary, O'Brien, Joan M, Simpson, Elizabeth M, Van Raamsdonk, Catherine D   +8 more
core  

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

Beyond bacterial defences: the role of lysozyme in cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Lysozyme (LYZ) is a multi‐functional secreted factor that encompasses both antibacterial and immunomodulatory functions. Emerging evidence highlights its complex role in tumour progression by directly influencing tumour cells and modulating the immune microenvironment.
Lei Wang, Qian Dong, Fuchu He, Zhiwen Gu, Aihua Sun   +4 more
wiley   +1 more source