Results 141 to 150 of about 25,326 (255)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Evolutionary Origin of Ocular Melanoma: Associations With rs12913832 G Allele Frequency and Latitude

Cancer Medicine, Volume 15, Issue 6, June 2026.
The rs12913832 derived (G) allele frequency (blue‐eye allele) was a markedly stronger predictor of ocular melanoma incidence than geographic latitude, with approximately 92% of the latitude effect mediated through allele frequency. These findings indicate that pigmentation‐related genetic variation contributes substantially to global differences in ...
Hans Witzenhausen, Hildur Helgadottir, Veronica Höiom, Roger Olofsson Bagge, Gustav Stålhammar   +4 more
wiley   +1 more source

Primary Tumor‐Associated Loss of the Y Chromosome and Clinical Outcome in Metastatic Colorectal Cancer

Genes, Chromosomes and Cancer, Volume 65, Issue 6, June 2026.
ABSTRACT Background Alterations of the Y chromosome are frequent events in solid tumors, yet their biological and clinical significance remains incompletely understood. In colorectal cancer (CRC), recent studies have suggested context‐dependent roles of Y‐linked genes in tumor progression, while the impact of tumor‐associated loss of the Y chromosome ...
Anaëlle Isnard, Marie Decraecker, Benjamin Fernandez, Denis Smith, Pierre Dubus, Sandrine Dabernat, Olivier Mansier, Samuel Amintas   +7 more
wiley   +1 more source

Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective

JEADV Clinical Practice, Volume 5, Issue 2, Page 402-414, June 2026.
Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek, Iris Zalaudek, Karolina Zarańska, Bożena Cybulska‐Stopa   +3 more
wiley   +1 more source

ABCB1 identifies a subpopulation of uveal melanoma cells with high metastatic propensity

, 2011
Metastasis of tumor cells to distant organs is the leading cause of death in melanoma. Yet, the mechanisms of metastasis remain poorly understood. One key question is whether all cells in a primary tumor are equally likely to metastasize or whether ...
Solange Landreville, Zachary T. Kneass, Olga A. Agapova, Landreville, Solange, Harbour, J William, Kneass, Zachary T, J. William Harbour, Salesse, Christian, Agapova, Olga A, Christian Salesse   +9 more
core   +1 more source

Metabolic Regulation of Immune Responses: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
FBP1 loss drives immune evasion and therapy resistance by enhancing glycolysis, STAT3 activation, and PD‐L1 expression, leading to T cell exhaustion and NK cell inhibition. FBP1 restoration, via LNP‐mRNA or epigenetic modulation, reverses these immunosuppressive effects, reactivates cytotoxic T cells, promotes M1 macrophage polarization, and enhances ...
Chunwei Li, Ziqiang Liu, Dezheng Kong, Zhengze Li, Yiming Yan, Yanyu Dong, Lili Zhu, JiaNing Cao, Zhirui Fan, Gautam Sethi, Lifeng Li   +10 more
wiley   +1 more source

Current management of uveal melanoma

, 2007
Uveal melanoma is the most common primary malignancy of the eye and frequently leads to metastatic death. Until the mid-20th Century, the only treatment for uveal melanoma was enucleation.
Harbour, J William, Ramaiya, Kamalesh J   +1 more
core   +1 more source

Uveal melanoma following Bruton's tyrosine inhibitor use for the treatment of hematologic malignancies

American Journal of Ophthalmology Case Reports
Purpose: To report two new cases and summarize one case of uveal melanoma following treatment of hematologic malignancies with Bruton's tyrosine kinase inhibitors.
Tara Murty, Jonathan H. Lin, Prithvi Mruthyunjaya   +2 more
doaj   +1 more source

Ribosomal Proteins in Cell Biology and Cancer

MedComm – Oncology, Volume 5, Issue 2, June 2026.
The functions of ribosomal proteins (RPs) extend beyond the conventional translation process, as they also regulate gene expression, stress responses, and disease progression. Dysregulation of RPs contributes to the onset and progression of various diseases, including cancer and ribosomopathies, underscoring their dual role as critical disease ...
Ao Zhang, Zeguang Sun, Xinyang Song, Xikun Zhou, Jing Li   +4 more
wiley   +1 more source