Results 81 to 90 of about 360,760 (179)

Fenofibrate potentiates the therapeutic efficacy of EZH2 inhibitors on melanoma via TRIM21‐ and OTUD4‐mediated EZH2 ubiquitination

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 11, Page 2675-2694, June 2026.
Background and Purpose EZH2 (enhancer of zeste homologue 2) inhibitors are an emerging class of drugs that target epigenetic regulation. However, their efficacy in solid tumours has been limited, partly due to drug‐induced upregulation of fatty acid synthesis.
Rui Cheng   +10 more
wiley   +1 more source

Effect of the Mutual Interaction of GPNMB and LPAR1 on Cellular Motility and Tumorigenicity in Mammary Epithelial Cells

open access: yesPathology International, Volume 76, Issue 6, June 2026.
GPNMB and LPAR1 form a positive feedback loop enhancing LPA signaling. LPA–LPAR1 activates RhoA–ROCK, driving actin reorganization and cell motility. GPNMB–LPAR1 signaling promotes tumorigenic potential. ABSTRACT Glycoprotein non‐metastatic melanoma protein B (GPNMB) is a poor prognostic factor, which is highly expressed in many types of malignant ...
Minori Kimura   +7 more
wiley   +1 more source

Epidemiology of Four Major Canine Tumours in the UK: Insights From a National Pathology Registry With Comparative Oncology Perspectives

open access: yesVeterinary and Comparative Oncology, Volume 24, Issue 2, Page 324-340, June 2026.
ABSTRACT Pet dogs with naturally occurring cancers provide valuable models for comparative oncology and pathology tumour registries offer a powerful resource for onco‐epidemiological research. Here, we analysed the Small Animal Veterinary Surveillance Network (SAVSNET) pathology‐based tumour registry (PTR), one of the largest veterinary tumour ...
José Rodríguez   +9 more
wiley   +1 more source

The WHO Classification of Genetic Tumour Syndromes: Considerations for histopathology

open access: yes
Histopathology, Volume 88, Issue 7, Page 1291-1294, June 2026.
Ian A Cree   +18 more
wiley   +1 more source

Case Report: Long-term response to multimodal treatment in metastatic uveal melanoma. [PDF]

open access: yesFront Immunol
Rifaldi F   +8 more
europepmc   +1 more source

Blurred vision as the first symptom of pancreatic cancer. [PDF]

open access: yesBMJ Case Rep
Pasztor D   +5 more
europepmc   +1 more source

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