Results 81 to 90 of about 87,820 (142)

Brachytherapy in the Management of Uveal Melanomas

open access: yes, 2014
Uveal melanoma is the most common intraocular tumor in adults. Clinical studies have shown similar patient survival rates after treatment of medium-sized melanomas when comparing plaque brachytherapy with radioactive iodine-125 versus enucleation. This
Samuray Tuncer
core   +1 more source

Functional validation of driver mutation‐specific uveal melanoma biomarkers: role of COL9A3 in cancer cell plasticity

open access: yesThe Journal of Pathology, Volume 270, Issue 2, Page 226-240, October 2026.
Abstract Uveal melanoma (UM) is a deadly ocular malignancy with well‐described genetic alterations that predict disease outcome. However, our current understanding of the biological underpinnings of high‐risk uveal melanoma progression remains relatively limited. Using RNA expression profiles from 250 patients with UM, we identified 12 novel biomarkers
QCC van den Bosch   +7 more
wiley   +1 more source

Acute and sudden death secondary to cardiac tamponade during anaesthetic recovery in a 21‐year‐old draught mule

open access: yesEquine Veterinary Education, Volume 38, Issue 10, Page e686-e689, October 2026.
Summary This case report is of educational value and contributes to the literature because it describes a unique death after anaesthesia due to cardiac tamponade from a rare cardiac neoplasm. In trying to diagnose the origin of chronic sinusitis, a geriatric mule mare was anaesthetised and during recovery, died acutely.
A. Carroll, J. Quandt, S. Dantino
wiley   +1 more source

Serous Neoplasms

open access: yes, 2014
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example.
D'ONOFRIO, Mirko   +17 more
core   +1 more source

Fatty Acid‐Binding Protein 5 Potentially Regulates the Proliferation and Metastasis of Uveal Melanoma Cells Through the PI3K/AKT/mTOR Signaling Pathway

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Single‐cell and bulk sequencing reveal SPON2, MATK, and FABP5 as prognostic indicators in uveal melanoma. We demonstrated that FABP5 promotes malignancy via the PI3K/AKT/mTOR pathway, as genetic knockdown impairs tumor growth and is rescued by 740Y‐P pharmacological pathway activation. These findings highlight FABP5 maybe as a critical driver of immune
Yue Du   +4 more
wiley   +1 more source

Posterior uveal melanoma in adolescents and children: current perspectives

open access: yes, 2018
Matthew V Fry,1 James J Augsburger,1 June Hall,2 Zélia M Corrêa21Department of Ophthalmology, College of Medicine, University of Cincinnati, Cincinnati, OH, USA; 2Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore ...
Hall J   +3 more
core  

A Multimodal Framework to Guide Solid Tumor Indications for Natural Killer Cell‐Based Therapy

open access: yesEuropean Journal of Immunology, Volume 56, Issue 9, September 2026.
This study integrates immunohistochemical evidence of NK cell infiltration in solid tumors, clinical outcomes of NK cell‐based therapies, and transcriptomic analyses of more than 10,000 TCGA samples. Together, these complementary datasets provide a multimodal framework for prioritizing tumor indications and informing the rational design of future NK ...
L. Chiossone   +4 more
wiley   +1 more source

A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus

open access: yes, 2017
Uveal melanoma, a rare malignant tumor of the eye, is predominantly observed in populations of European ancestry. A genome-wide association study of 259 uveal melanoma patients compared to 401 controls all of European ancestry revealed a candidate locus ...
Jean-François Deleuze   +31 more
core   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

open access: yesJournal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1218-1229, September 2026.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

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