Results 171 to 180 of about 156,233 (327)
Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition
Advanced Science, EarlyView.Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han +9 more
wiley +1 more source
Features of V‐ATPases that distinguish them from F‐ATPases [PDF]
, 2001 Natalie Perzov +3 more
openalex +1 more source
Opposing Pressures of Speed and Efficiency Guide the Evolution of Molecular Machines. [PDF]
, 2019 Many biomolecular machines need to be both fast and efficient. How has evolution optimized these machines along the tradeoff between speed and efficiency?
Dill, Ken, Wagoner, Jason
core
Advanced Science, EarlyView.Spatially resolved Shewanella–acetogen interactions link DIET and MET pathways to acetate formation, offering a generalizable framework for designing structured, high‐efficiency microbial electrosynthesis systems. Abstract Precise manipulation of interspecies electron transfer (IET) is critical for advancing microbial electrosynthesis (MES) toward ...
Jing Zhang +8 more
wiley +1 more source
Cadmium Effects of Metallothionein Expression in Epididymal Epithelium of Rat [PDF]
, 2007 Cadmium (Cd) is a heavy metal with public health importance because it is known to present environmental and occupational hazards and a threatening to public health. Cd has negative effects on the liver, kidney, and male fertility.
Tang, Zilue
core
Advanced Science, EarlyView.This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou +5 more
wiley +1 more source
V-ATPase expression in the mouse olfactory epithelium
, 2008 Teodor G. Păunescu +3 more
openalex +2 more sources
Crystal and NMR Structures Give Insights into the Role and Dynamics of Subunit F of the Eukaryotic V-ATPase from Saccharomyces cerevisiae [PDF]
, 2013 Sandip Basak +4 more
openalex +1 more source
Advanced Science, EarlyView.This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong +15 more
wiley +1 more source