Results 111 to 120 of about 3,565,976 (274)

Fitness cost of tet(A) type I variant-mediated tigecycline resistance in Klebsiella pneumoniae

Journal of Global Antimicrobial Resistance
Objective: The aim of the present study is to explore the impact of the tet(A) type I variant (tetA-v1) on its fitness effect in Klebsiella pneumoniae. Methods: Clinical K. pneumoniae strains were utilized as parental strains to generate strains carrying
Yuanyuan Li, Tianyu Wang, Yunbing Li, Chen Xu, Tianyi Wang, Lili Huang, Xiangkun Zeng, Guangfen Zhang, Chunli Li, Ning Dong   +9 more
doaj   +1 more source

Pattern Motion Processing by MT Neurons

Frontiers in Neural Circuits, 2019
Based on stimulation with plaid patterns, neurons in the Middle Temporal (MT) area of primate visual cortex are divided into two types: pattern and component cells. The prevailing theory suggests that pattern selectivity results from the summation of the
Parvin Zarei Eskikand, Tatiana Kameneva, Tatiana Kameneva, Anthony N. Burkitt, David B. Grayden, Michael R. Ibbotson   +5 more
doaj   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Target dependence of orientation and direction selectivity of corticocortical projection neurons in the mouse V1

Frontiers in Neural Circuits, 2013
Higher order visual areas that receive input from the primary visual cortex (V1) are specialized for the processing of distinct features of visual information.
Teppei eMatsui, Kenichi eOhki, Kenichi eOhki   +2 more
doaj   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Auditory cortex conveys non-topographic sound localization signals to visual cortex

Nature Communications
Spatiotemporally congruent sensory stimuli are fused into a unified percept. The auditory cortex (AC) sends projections to the primary visual cortex (V1), which could provide signals for binding spatially corresponding audio-visual stimuli.
Camille Mazo, Margarida Baeta, Leopoldo Petreanu   +2 more
doaj   +1 more source

Gamma Frequency and the Spatial Tuning of Primary Visual Cortex.

PLoS ONE, 2016
Visual stimulation produces oscillatory gamma responses in human primary visual cortex (V1) that also relate to visual perception. We have shown previously that peak gamma frequency positively correlates with central V1 cortical surface area.
Sarah Gregory, Marco Fusca, Geraint Rees, D Samuel Schwarzkopf, Gareth Barnes   +4 more
doaj   +1 more source

Polymer Matrix‐Based 3D Culture Significantly Enhances the Differentiation and Immunomodulatory Functions of Human Adipose‐Derived Stem Cells

Advanced Science, EarlyView.
The 3D culture of human adipose‐derived stem cells (hADSCs) on a crosslinked cyclosiloxane‐based poly‐Z matrix platform enables the formation of spheroid structures enriched with extracellular matrix (ECM). These ECM‐enriched hADSC spheroids cultured on poly‐Z exhibit enhanced differentiation potential, immunomodulatory capacity, and in vivo ...
Changjin Seo, Dohyeon Kim, Junhyuk Song, Sun‐Young Kim, Youngju Son, Afia Tasnim Rahman, Sangyong Jon   +6 more
wiley   +1 more source

Separation of bimodal fMRI responses in mouse somatosensory areas into V1 and non-V1 contributions

Scientific Reports
Multisensory integration is necessary for the animal to survive in the real world. While conventional methods have been extensively used to investigate the multisensory integration process in various brain areas, its long-range interactions remain less ...
Thi Ngoc Anh Dinh, Hyun Seok Moon, Seong-Gi Kim   +2 more
doaj   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source