Results 81 to 90 of about 5,753 (291)

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Analysis of Whole-Genome Sequences of Infectious laryngotracheitis Virus Isolates from Poultry Flocks in Canada: Evidence of Recombination

Viruses, 2020
Infectious laryngotracheitis virus (ILTV) is a herpes virus that causes an acute respiratory disease of poultry known as infectious laryngotracheitis (ILT).
Ana Perez Contreras, Frank van der Meer, Sylvia Checkley, Tomy Joseph, Robin King, Madhu Ravi, Delores Peters, Kevin Fonseca, Carl A. Gagnon, Chantale Provost, Davor Ojkic, Mohamed Faizal Abdul-Careem   +11 more
doaj   +1 more source

OUTER MEMBRANE PROTEIN PROFILING OF PASTEURELLA MULTOCIDA [PDF]

Pakistan Veterinary Journal, 2007
Outer membrane proteins (OMPs) play a significant role in the pathogenesis of Pasteurellosis. OMPs of Pasteurella multocida (P. multocida) B:2 strain were characterized by using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE ...
R. MUNIR, D. SHAHWAR1, U. FAROOQ, I. NAWAZ1, I. SHAHZAD1 AND A. KHANUM1
doaj  

The comparative value of feline virology research: can findings from the feline lentiviral vaccine be translated to humans? [PDF]

, 2017
Feline immunodeficiency virus (FIV) is a lentivirus of domestic cats that shares several similarities with its human counterpart, human immunodeficiency virus (HIV).
Beczkowski, Paweł M., Harris, Matthes, Hosie, Margaret J., Logan, Nicola, Techakriengkrai, Navapon, Willett, Brian   +5 more
core   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

STUDY OF NEUROVIRULENT PROPERTIES OF VACCINE AGAINST CULTURAL LIVE RUBELLA

Педиатрическая фармакология, 2010
Experts at FSUE R&D Centre Microgen of the RF’s Healthcare Ministry have developed a national drug designed to prevent rubella — Cultural live vaccine against rubella on the basis of vaccinal strain RA 27/3.
A.N. Mironov, A.A. Tsaan, D.S. Bushmenkov, A.A. Romanova, V.A. Merkulov, N.N. Stepanov   +5 more
doaj   +2 more sources

A Study of Biokinetic Peculiarities and Optimization of the Conditions for Culturing Vibrio cholerae Strains Overproducing Protective Antigens Suitable for Use in the Production

Проблемы особо опасных инфекций, 2008
Described in the work are the major biokinetic criteria of the submerged growth process of V. cholerae Ol strains (classical and eltor biovars), O139, non-Ol and non-O139 serogroups, capable of overproducing the main protective antigens (Ol and O139 ...
O. A. Volokh, I. A. Shepelev, S. P. Zadnova, I. M. Krepostnova, S. A. Yeremin   +4 more
doaj   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Genetic Structure of SSR1 & SSR2 loci from Iranian Mycobacterium Avium Subspecies Paratuberculosis Isolates by a Short Sequence Repeat Analysis Approach

Medical Laboratory Journal, 2015
Background and Objective: Paratuberculosis has been repeatedly reported from Iranian ruminant herds. The extrem fastidious nature of Mycobacterium avium subspecies paratuberculsos hinders genomic diversity studies of the pathogen.
Aida Chalesh, Keyvan Tadayon
doaj