Results 11 to 20 of about 44,954 (187)

Sporadic detection of vaccine-derived poliovirus type 2 using next-generation sequencing in Canadian wastewater in August of 2022 [PDF]

Scientific Reports
In July 2022, an unvaccinated young adult living in Rockland County, New York became paralyzed due to a vaccine-derived poliovirus type 2 (VDPV2) infection that was internationally transmitted. Wastewater surveillance in New York State uncovered VDPV2 in
Grace E. Seo, Russell Mandes, Nathan D. Wright, Justin P. Hawkins, Anneliese Landgraff, Ravinder Lidder, Umar Mohammed, Chand S. Mangat, Anne-Sophie Michel, Judith Fafard, Darian Hole, Andrea D. Tyler, Marli Vlok, Elsie Grudeski, Tim F. Booth, Anna Majer   +15 more
doaj   +4 more sources

Early detection of a circulating pre-vaccine-derived poliovirus type 1 (pre-VDPV1) variant linked to an acute flaccid polio case prior to VDPV1 emergence, Israel, 2024 to 2025 [PDF]

Eurosurveillance
We report the emergence and evolution of a circulating vaccine-derived poliovirus type 1 (cVDPV1) outbreak in Israel, linked to a vaccine-associated paralytic poliomyelitis case.
Merav Weil
doaj   +4 more sources

Vaccine Derived Poliovirus (VDPV). [PDF]

Le infezioni in medicina, 2023
Poliomyelitis is caused by Poliovirus, a member of a large group of enteroviruses. Vaccine-derived polioviruses (VDPVs) stem from mutated live poliovirus, which is contained in the Oral Polio Virus vaccine (OPV). In addition, the emergence of VDPV is one of the global challenges for the eradication of poliomyelitis.
Mohanty, Aroop, Rohilla, Ranjana, Zaman, Kamran, Hada, Vivek, Dhakal, Surakchhya, Shah, Abhishek, Padhi, Bijaya Kumar, Al-qaim, Zahra Haleem, Altawfiq, Kauthar Jaffar A., Tirupathi, Raghavendra, Sah, Ranjit, Al-Tawfiq, Jaffar A.   +11 more
europepmc   +4 more sources

Update on Vaccine-Derived Poliovirus Outbreaks — Worldwide, January 2021–December 2022 [PDF]

MMWR. Morbidity and Mortality Weekly Report, 2023
Circulating vaccine-derived poliovirus (cVDPV) outbreaks* can occur when oral poliovirus vaccine (OPV, containing one or more Sabin-strain serotypes 1, 2, and 3) strains undergo prolonged circulation in under-vaccinated populations, resulting in genetically reverted neurovirulent virus (1,2).
Bigouette, John Paul, Henderson, Elizabeth, Traoré, Mohamed A., Wassilak, Steven G. F., Jorba, Jaume, Mahoney, Frank, Bolu, Omotayo, Diop, Ousmane M., Burns, Cara C.   +8 more
europepmc   +4 more sources

Asymptomatic immunodeficiency-associated vaccine-derived poliovirus infections in two UK children [PDF]

Nature Communications, 2023
AbstractIncreasing detections of vaccine-derived poliovirus (VDPV) globally, including in countries previously declared polio free, is a public health emergency of international concern. Individuals with primary immunodeficiency (PID) can excrete polioviruses for prolonged periods, which could act as a source of cryptic transmission of viruses with ...
Anika Singanayagam, Dimitra Klapsa, Shirelle Burton-Fanning, Julian Hand, Thomas Wilton, Laura Stephens, Ryan Mate, Benjamin Shillitoe, Cristina Celma, Mary Slatter, Terry Flood, Robin Gopal, Javier Martin, Maria Zambon   +13 more
europepmc   +7 more sources

Immunodeficiency-Related Vaccine-Derived Poliovirus (iVDPV) Infections: A Review of Epidemiology and Progress in Detection and Management [PDF]

Pathogens
Individuals with certain primary immunodeficiency disorders (PID) may be unable to clear poliovirus infection after exposure to oral poliovirus vaccine (OPV).
Concepcion F. Estivariz, Elisabeth R. Krow-Lucal, Ondrej Mach   +2 more
doaj   +3 more sources

Stem Cell Transplant in Immune-deficiency–associated Vaccine-derived Poliovirus [PDF]

Open Forum Infectious Diseases
Abstract Patients with severe primary immunodeficiency are at risk for complications from live-attenuated vaccines. Here, we report a case of a vaccine-associated paralytic polio and Bacille Calmette-Guérin disease in a 6-month-old girl with severe combined immunodeficiency resulting from homozygous recombinant activating gene 1 ...
Heena Ranchod, Wayne Howard, Adele Roux, Walda van Zyl, Pieter Ekermans, Sylvia van den Berg, Lerato Seakamela, Koketso Makua, Mukhlid Yousif, Rosinah Sibiya, Heleen Du Plessis, Emmanuel Phalane, Kerrigan McCarthy, Shelina Moonsamy, David Reynders, Jeffrey Hincks, Melinda S Suchard, Nicolette M du Plessis   +17 more
europepmc   +5 more sources

A circulating vaccine-derived poliovirus type 2 outbreak in a chronic conflict setting: a descriptive epidemiological study in South Sudan – 2020 to 2021 [PDF]

BMC Infect Dis, 2023
Background In this study, we describe the epidemiological profile of an outbreak of the circulating Vaccine Derived Polio Virus type 2 in South Sudan from 2020 to 2021. Method We conducted a retrospective descriptive epidemiological study using data from
Ayesheshem Ademe Tegegne, Atem Nathan Anyuon, George Awzenio Legge, Melisachew Adane Ferede, Zingbondo Isaac, Kirbak Anthony Laku, Sibhatu Biadgilign, Ochan Taban David Kilo, Fabian Ndenzako, Modjirom Ndoutabé, Olushayo Oluseun Olu, Sylvester Maleghemi   +11 more
europepmc   +3 more sources

Update on Vaccine-Derived Poliovirus Outbreaks - Worldwide, January 2023-June 2024. [PDF]

MMWR Morb Mortal Wkly Rep
Circulating vaccine-derived polioviruses (cVDPVs) can emerge and lead to outbreaks of paralytic polio as well as asymptomatic transmission in communities with a high percentage of undervaccinated children.
Namageyo-Funa A, Greene SA, Henderson E, Traoré MA, Shaukat S, Bigouette JP, Jorba J, Wiesen E, Bolu O, Diop OM, Burns CC, Wassilak SGF.   +11 more
europepmc   +2 more sources

Monitoring the Risk of Type-2 Circulating Vaccine-Derived Poliovirus Emergence during Roll-Out of Type-2 Novel Oral Polio Vaccine [PDF]

Vaccines (Basel)
Background/Objectives: Although wild poliovirus type 2 has been eradicated, prolonged transmission of the live-attenuated virus contained in the type-2 oral polio vaccine (OPV2) in under-immunized populations has led to emergence of circulating vaccine ...
Peak CM, Lyons H, Voorman A, Gray EJ, Cooper LV, Blake IM, Hawes K, Bandyopadhyay AS.   +7 more
europepmc   +3 more sources