Coordinated Response to Imported Vaccine-Derived Poliovirus Infection, Barcelona, Spain, 2019–2020 [PDF]
In 2019, the Public Health Agency of Barcelona, Spain, was notified of a vaccine-derived poliovirus infection. The patient had an underlying common variable immunodeficiency and no signs of acute flaccid paralysis. We describe the ongoing coordinated response to contain the infection, which included compassionate-use treatment with pocapavir.
Dolores Álamo-Junquera +15 more
openaire +5 more sources
First isolation of vaccine-derived poliovirus in Slovakia
In April 2003, a vaccine-derived poliovirus Sabin 2 (VDPV) was isolated from sewage water in Vrakuna, a Bratislava city district in western ...
Eva, Máderová +4 more
openaire +2 more sources
Update on Vaccine-Derived Poliovirus Outbreaks — Worldwide, July 2019–February 2020 [PDF]
Circulating vaccine-derived polioviruses (cVDPVs) can emerge in areas with low poliovirus immunity and cause outbreaks* of paralytic polio (1-5). Among the three types of wild poliovirus, type 2 was declared eradicated in 2015 (1,2). The use of trivalent oral poliovirus vaccine (tOPV; types 1, 2, and 3 Sabin strains) ceased in April 2016 via a 1-month ...
Alleman, Mary M. +9 more
openaire +2 more sources
Detection of minority variants within bovine respiratory syncytial virus populations using oligonucleotide-based microarrays [PDF]
Microarray technology, originally developed for highly parallel examination of gene expression is regarded as a potential tool in prognosis and diagnosis.
Baranowski, Eric +4 more
core +3 more sources
Circulating vaccine-derived poliovirus: a menace to the end game of polio eradication
The World Health Organisation Western Pacific Region countries were declared free of polio in 2000 until a polio outbreak involving 305 cases occurred in Indonesia in 2006.
Long Chiau Ming +4 more
doaj +1 more source
Evolution of a rare vaccine-derived multirecombinant poliovirus
Recombination is one of the mechanisms by which viral genomes evolve. A vaccine-derived multirecombinant poliovirus strain was isolated from a 5-month-old child with vaccine-associated paralytic poliomyelitis after oral poliovirus vaccine administration. The isolate had an S2/S1/S2/S1 primary genomic structure as revealed by restriction fragment length
Ioannis, Karakasiliotis +2 more
openaire +2 more sources
Achieving High Poliovirus Antibody Seroprevalence in Areas at Risk of Vaccine-Derived Poliovirus Transmission—Niger Experience [PDF]
Abstract Background Outbreaks of vaccine-derived poliovirus type 2 (VDPV2) continue to expand across Africa. We conducted a serological survey of polio antibodies in high–polio risk areas of Niger to assess risk of poliovirus outbreaks. Methods
Ousmane, Sani +8 more
openaire +2 more sources
Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses. [PDF]
RNA viruses, such as poliovirus, have a great evolutionary capacity, allowing them to quickly adapt and overcome challenges encountered during infection.
Andino, Raul +6 more
core +3 more sources
Immunization strategies targeting newly arrived migrants in Non-EU countries of the mediterranean basin and black sea [PDF]
Background: The World Health Organization recommends that host countries ensure appropriate vaccinations to refugees, asylum seekers and migrants. However, information on vaccination strategies targeting migrants in host countries is limited. Methods: In
Declich, Silvia +7 more
core +1 more source
Managing the risk of circulating vaccine-derived poliovirus during the endgame: oral poliovirus vaccine needs [PDF]
The Global Polio Eradication Initiative plans for coordinated cessation of oral poliovirus vaccine (OPV) use, beginning with serotype 2-containing OPV (i.e., OPV2 cessation) followed by the remaining two OPV serotypes (i.e., OPV13 cessation). The risk of circulating vaccine-derived poliovirus (cVDPV) outbreaks after OPV cessation of any serotype ...
Duintjer Tebbens, Radboud J. +1 more
openaire +2 more sources

