Results 11 to 20 of about 89 (85)

Vaccine-induced immune thrombotic thrombocytopenia [PDF]

Best Practice & Research Clinical Haematology, 2022
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is primarily a complication of adenoviral vector-based covid-19 vaccination. In VITT, thrombocytopenia and thrombosis mediated by anti-platelet factor 4 (PF4) antibodies can be severe, often characterized by thrombosis at unusual sites such as the cerebral venous sinus and splanchnic circulation.
Adam J. Kanack, Anand Padmanabhan
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The aetiopathogenesis of vaccine-induced immune thrombotic thrombocytopenia [PDF]

Clinical Medicine, 2022
In the new science emanating from the COVID-19 pandemic, effective vaccine development has made a huge difference and saved countless lives. Vaccine roll-out led to the identification of rare cases of severe thrombotic and thrombocytopenic problems in some recipients.
Toh, Cheng-Hock, Wang, Guozheng, Parker, Alan L   +2 more
openaire   +3 more sources

Vaccine-induced immune thrombotic thrombocytopenia

Blood, 2023
Abstract Within the first months of the COVID-19 vaccination campaign, previously healthy recipients who developed severe thrombosis (often cerebral and/or splanchnic vasculature) and thrombocytopenia typically after adenoviral vector-based vaccination were identified. Similarities between this syndrome, vaccine-induced immune thrombotic
Douglas B. Cines, Andreas Greinacher
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Perspectives on vaccine induced thrombotic thrombocytopenia

Journal of Autoimmunity, 2021
As the novel SARS-CoV-2 continues to infect numerous individuals worldwide, one of the leading approaches in dealing with the global health crisis is vaccination against the COVID-19. Due to recent reports, vaccination with ChAdOx1 nCov-19 (developed by Oxford and AstraZeneca) may result in a vaccine-induced catastrophic thrombotic thrombocytopenia ...
Dotan, Arad, Shoenfeld, Yehuda
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Thrombocytopenia in COVID‑19 and vaccine‑induced thrombotic thrombocytopenia

International Journal of Molecular Medicine, 2022
The highly heterogeneous symptomatology and unpredictable progress of COVID‑19 triggered unprecedented intensive biomedical research and a number of clinical research projects. Although the pathophysiology of the disease is being progressively clarified, its complexity remains vast.
Mantzourani, Marina, Takan, Isil, Geronikolou, Styliani, Pavlopoulou, ATHANASIA, Chrousos, George   +4 more
openaire   +5 more sources

A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia [PDF]

Journal of Community Hospital Internal Medicine Perspectives, 2021
SARS-CoV-2, which originated in China in late 2019, has spread rapidly resulting in a global pandemic. Multiple vaccines have been developed to help prevent COVID-19 infection. Similar to other vaccines, common side effects including fever, fatigue, myalgias have occurred; however, episodes of more serious side effects have been noted.
Abhinandan Chittal, Shiavax Rao, Pallavi Lakra, Natalia Nacu, Christopher Haas   +4 more
openaire   +3 more sources

PF4 Immunoassays in Vaccine-Induced Thrombotic Thrombocytopenia

New England Journal of Medicine, 2021
Laboratory Method to Detect VITT The rare vaccine-induced immune thrombotic thrombocytopenia that may follow adenovirus-based Covid-19 vaccination resembles heparin-induced thrombocytopenia, but ra...
Vayne, Caroline, Rollin, Jérôme, Gruel, Yves, Pouplard, Claire, Galinat, Hubert, Huet, Olivier, Mémier, Vincent, Geeraerts, Thomas, Marlu, Raphael, Pernod, Gilles, Mourey, Guillaume, Fournel, Alexandra, Cordonnier, Charlotte, Susen, Sophie   +13 more
openaire   +4 more sources

Lessons from vaccine-induced immune thrombotic thrombocytopenia [PDF]

Nature Reviews Immunology, 2021
Adenoviral vector vaccines are effective against SARS-CoV-2 but have been associated with a rare side effect termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we discuss our understanding of how vaccine-induced antibodies to platelet factor 4 (PF4) form immune complexes that activate platelets and trigger the thrombotic events ...
John Greenhow Kelton, Donald Mitchell Arnold, Ishac Nazy   +2 more
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Vaccine-Induced Thrombotic Thrombocytopenia: A Case Report

Cureus, 2022
While the number of people who have been vaccinated against coronavirus disease 2019 (COVID-19) in Portugal keeps rising, the risk of complications, although rare, keeps rising too. We report a case of vaccine-induced thrombotic thrombocytopenia (VITT) in a 30-year-old previously healthy male after vaccination with Ad26.COV2.S. The patient presented to
Silva, Luciana, Pombal, Rita, Fidalgo, Mariana, Freitas, Andreia, Barbosa, Manuel, Magalhães, Luisa, Correia, Margarida, Valente, João   +7 more
openaire   +2 more sources

Recognizing Vaccine-Induced Immune Thrombotic Thrombocytopenia

Critical Care Medicine, 2021
OBJECTIVES: Vaccine-induced immune thrombotic thrombocytopenia is an unexpected consequence of the coronavirus disease 2019 pandemic era. We reviewed the pathogenesis, clinical presentation, diagnosis, and treatment of this rare side effect.
Iba, Toshiaki, Levy, Jerrold H., Warkentin, Theodore E.   +2 more
openaire   +3 more sources