Results 21 to 30 of about 89 (85)

Understanding vaccine‐induced thrombotic thrombocytopenia (VITT)

Internal Medicine Journal, 2022
AbstractVaccine‐induced thrombotic thrombocytopenia (VITT) is a rare, but serious, syndrome characterised by thrombocytopenia, thrombosis, a markedly raised D‐dimer and the presence of anti‐platelet factor‐4 (PF4) antibodies following COVID‐19 adenovirus vector vaccination.
Caroline Dix, James McFadyen, Angela Huang, Sanjeev Chunilal, Vivien Chen, Huyen Tran   +5 more
openaire   +4 more sources

SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia [PDF]

Thrombosis Research, 2022
SARS-CoV-2 vaccines have been carefully developed and significantly alleviate the global pandemic. However, a rare but severe complication after vaccination of adenoviral vector vaccines has attracted worldwide attention. It is characterized by thrombosis at unusual sites (often cerebral or abdominal), thrombocytopenia, and the presence of antibodies ...
Liu, Yumei, Shao, Zonghong, Wang, Huaquan   +2 more
openaire   +3 more sources

A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia

Cureus, 2022
This report discusses a case of a 37-year-old female who developed vaccine-induced thrombotic thrombocytopenia (VITT) after receiving the Johnson and Johnson COVID-19 vaccination. The patient first presented to the ED with complaints of a worsening headache. Labs were significant for thrombocytopenia with a platelet count of 22,000, and the patient was
Harrison, Hailey, Rezaei, Hadi, Dalal, Nimit   +2 more
openaire   +2 more sources

Pathogenesis of vaccine-induced immune thrombotic thrombocytopenia (VITT)

Seminars in Hematology, 2022
Vaccine-induced immune thrombotic thrombocytopenia (VITT; synonym, thrombosis with thrombocytopenia syndrome, is associated with high-titer immunoglobulin G antibodies directed against platelet factor 4 (PF4). These antibodies activate platelets via platelet FcγIIa receptors, with platelet activation greatly enhanced by PF4.
Andreas Greinacher, Linda Schönborn, Florian Siegerist, Leif Steil, Raghavendra Palankar, Stefan Handtke, Alexander Reder, Thomas Thiele, Konstanze Aurich, Karen Methling, Michael Lalk, Uwe Völker, Nicole Endlich   +12 more
openaire   +3 more sources

Vaccine-induced immune thrombotic thrombocytopenia and patients with cancer

Thrombosis Research, 2022
Vaccines to combat SARS-CoV-2 infection and the COVID-19 pandemic were quickly developed due to significant and combined efforts by the scientific community, government agencies, and private sector pharmaceutical and biotechnology companies. Following vaccine development, which took less than a year to accomplish, randomized placebo controlled clinical
Connors, Jean M., Iba, Toshiaki
openaire   +2 more sources

Deep vein thrombosis as thrombotic sequelae of vaccine-induced thrombotic thrombocytopenia

Oxford Medical Case Reports, 2023
Abstract Administration of the ChAdOx1 nCoV-19 (AstraZeneca) vaccination has recently been associated with rare, unusual cases of thrombotic events. We report a case of a 55-year-old woman who presented to hospital with headaches, petechial rashes and bruising—7 days after receiving her first vaccine dose.
Racheal Osei, Saad Ahmed, David Morrow, Sarbast Hamid, Peter Hawkins, Mahalakshmi Mohan   +5 more
openaire   +2 more sources

NETosis and thrombosis in vaccine-induced immune thrombotic thrombocytopenia

Nature Communications, 2022
Abstract Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare yet serious adverse effect of the adenoviral vector vaccines ChAdOx1 nCoV-19 (AstraZeneca) and Ad26.COV2.S (Janssen) against COVID-19. The mechanisms involved in clot formation and thrombocytopenia in VITT are yet to be fully determined.
Halina H. L. Leung, Jose Perdomo, Zohra Ahmadi, Shiying S. Zheng, Fairooj N. Rashid, Anoop Enjeti, Stephen B. Ting, James J. H. Chong, Beng H. Chong   +8 more
openaire   +3 more sources

Vaccine-Induced Thrombotic Thrombocytopenia: Insights from Blood Smear [PDF]

Thrombosis and Haemostasis, 2021
Vaccine-induced thrombotic thrombocytopenia (VITT) is a thrombotic complication mimicking heparin induced thrombocytopenia (HIT). This very rare but severe thrombotic complication occurs post vaccination against SARS-Cov-2. Diagnosis of VITT remains challenging, but a current consensus report suggests a 10-point guideline for early detection of VITT ...
Martin Federbusch, Silke Zimmermann, Berend Isermann, Shrey Kohli   +3 more
openaire   +2 more sources

Eltrombopag for refractory vaccine-induced immune thrombotic thrombocytopenia

Journal of Thrombosis and Thrombolysis, 2021
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a life-threatening complication described after administration of recombinant adenoviral vector encoding the spike protein antigen of Severe Acute Respiratory Syndrome CoronaVirus-2. The syndrome is characterized by platelet consumption and thrombosis.
Maraziti, Giorgio, Becattini, Cecilia
openaire   +4 more sources

COVID-19 vaccine-induced immune thrombotic thrombocytopenia

Annals of Thoracic Medicine, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus responsible for the pandemic coronavirus disease 19 (COVID-19). It has significant impact on human health and public safety along with negative social and economic consequences.
Malay Sarkar, Irappa V Madabhavi, Pham Nguyen Quy, Manjunath B Govindagoudar   +3 more
openaire   +3 more sources