Results 91 to 100 of about 2,081,901 (408)

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Analysis of COVID-19 in India using vaccine epidemic model incorporating vaccine effectiveness and herd immunity [PDF]

arXiv, 2022
COVID-19 will be a continuous threat to human population despite having a few vaccines at hand until we reach the endemic state through natural herd immunity and total immunization through universal vaccination. However, the vaccine acts as a practical tool for reducing the massive public health problem and the emerging economic consequences that the ...
arxiv  

Asymmetric participation of defenders and critics of vaccines to debates on French-speaking Twitter [PDF]

Sci Rep 10, 6599 (2020). https://doi.org/10.1038/s41598-020-62880-5, 2019
For more than a decade, doubt about vaccines has become an increasingly important global issue. Polarization of opinions on this matter, especially through social media, has been repeatedly observed, but details about the balance of forces are left unclear.
arxiv   +1 more source

Burden of typhoid fever in low-income and middle-income countries: a systematic, literature-based update with risk-factor adjustment

The Lancet Global Health, 2014
Background: No access to safe water is an important risk factor for typhoid fever, yet risk-level heterogeneity is unaccounted for in previous global burden estimates.
Dr. Vittal Mogasale, PhD, Brian Maskery, PhD, R Leon Ochiai, DPhil, Jung Seok Lee, MS, Vijayalaxmi V Mogasale, MD, Enusa Ramani, MSc, Young Eun Kim, MS, Jin Kyung Park, PhD, Thomas F Wierzba, PhD   +8 more
doaj   +1 more source

Vaccination with complete adjuvant-added inactivated virus vaccine of Japanese encephalitis to swine, rabbits and chicks for preventing viremia (epidemiological study on Japanese encephalitis 25) [PDF]

, 1969
As a step towards the elimination of Japanese encephalitis virus in natural surroundings, we inoculated pigs, rabbits and chicks with inactivated Japanese encephalitis vaccine supplemented with complete or incomplete Freund's adjuvant twice at one-week ...
Jitsunari, Fumihiko, Kitamura, Naoji, Nagao, Yutaka, Ogata, Masana   +3 more
core   +1 more source

Vaccines, Vaccination, and Vaccinology [PDF]

The Journal of Infectious Diseases, 2003
Although the demonstration in 1796 by Edward Jenner that vaccinia virus could protect against smallpox was epochal, he was following the path opened by the ancients who had used the smallpox virus itself in the practice of variolation. The work of Louis Pasteur on chicken cholera opened the way to vaccine development in the laboratory.
openaire   +3 more sources

Vaccine and Vaccination: On Field Research

Vaccines, 2022
Historically, vaccinations have enabled the eradication, elimination, and control of many debilitating diseases [...]
Francesca Gallè, Christian Napoli
openaire   +3 more sources

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

New England Journal of Medicine, 2021
Background Early clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a recombinant nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that contains the full-length spike glycoprotein of the prototype ...
P. Heath, E. Galiza, D. Baxter, M. Boffito, D. Browne, Fiona Burns, D. Chadwick, R. Clark, C. Cosgrove, J. Galloway, A. Goodman, Amardeep Heer, A. Higham, Shalini Iyengar, A. Jamal, Christopher Jeanes, P. Kalra, Christina Kyriakidou, D. McAuley, Agnieszka Meyrick, A. Minassian, J. Minton, P. Moore, Imrozia Munsoor, Helen Nicholls, O. Osanlou, J. Packham, Carol H. Pretswell, Alberto San Francisco Ramos, D. Saralaya, R. Sheridan, Richard Smith, R. Soiza, P. Swift, E. Thomson, J. Turner, M. E. Viljoen, G. Albert, I. Cho, F. Dubovsky, G. Glenn, J. Rivers, A. Robertson, Kathy Smith, S. Toback   +44 more
semanticscholar   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Development of Middle East Respiratory Syndrome Coronavirus vaccines – advances and challenges

Human Vaccines & Immunotherapeutics, 2018
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an emerging pathogen with the potential to pose a threat to global public health. Sporadic cases and outbreaks continue to be reported in the Middle East, and case fatality rates remain high at ...
Heeyoun Cho, Jean-Louis Excler, Jerome H. Kim, In-Kyu Yoon   +3 more
doaj   +1 more source