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Racing against COVID-19: a vaccines strategy for Europe. Bruegel Policy Contribution Issue n˚7 | April 2020 [PDF]

, 2020
The fast development of vaccines is an essential part of the long-term solution to COVID-19, but vaccine development has high costs and carries the risk of high failure rates.
Veugelers, Reinhilde, Zachmann, Georg.
core   +1 more source

Vaccination [PDF]

Science, 1894
n ...
openaire   +3 more sources

Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in adult patients with autoimmune inflammatory rheumatic diseases and in the general population: a multicentre study

Annals of the Rheumatic Diseases, 2021
Introduction Vaccination represents a cornerstone in mastering the COVID-19 pandemic. Data on immunogenicity and safety of messenger RNA (mRNA) vaccines in patients with autoimmune inflammatory rheumatic diseases (AIIRD) are limited.
V. Furer, T. Eviatar, D. Zisman, H. Peleg, D. Paran, D. Levartovsky, M. Zisapel, O. Elalouf, I. Kaufman, R. Meidan, A. Broyde, A. Polachek, J. Wollman, I. Litinsky, K. Meridor, H. Nochomovitz, Adi Silberman, D. Rosenberg, J. Feld, A. Haddad, Tal Gazzit, M. Elias, N. Higazi, F. Kharouf, G. Shefer, O. Sharon, S. Pel, S. Nevo, O. Elkayam   +28 more
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Neutrophil killing of Staphylococcus aureus in diabetes, obesity and metabolic syndrome: a prospective cellular surveillance study

Diabetology & Metabolic Syndrome, 2017
Background Obesity, metabolic syndrome (MetS), and diabetes are frequent in surgical populations and can enhance susceptibility to postoperative surgical site infections.
Ingrid Lea Scully, Lisa Kristin McNeil, Sudam Pathirana, Christine Lee Singer, Yongdong Liu, Stanley Mullen, Douglas Girgenti, Alejandra Gurtman, Michael W. Pride, Kathrin Ute Jansen, Paul L. Huang, Annaliesa S. Anderson   +11 more
doaj   +1 more source

A GMMA-CPS-Based Vaccine for Non-Typhoidal Salmonella

Vaccines, 2021
Non-typhoidal Salmonella are a major cause of gastroenteritis worldwide, as well as causing bloodstream infections in sub-Saharan Africa with a high fatality rate. No vaccine is currently available for human use.
Akosiererem S. Sokaribo, Sumudu R. Perera, Zoe Sereggela, Ryan Krochak, Lindsay R. Balezantis, Xiaohui Xing, Shirley Lam, William Deck, Sam Attah-Poku, Dennis Wade Abbott, Shantanu Tamuly, Aaron P. White   +11 more
doaj   +1 more source

Brain damage following whooping cough vaccination : is it time to lay the myth to rest? [PDF]

, 1998
Whooping cough causes significant morbidity and mortality, especially in early infancy. Although an effective vaccine exists, vaccine uptake in Malta was previously disappointing due to the general public’s and the medical community’s doubts regarding ...
Busuttil, Ray, Grech, Victor E.
core  

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
BackgroundPolymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development.
Anders, Robin F., Barry, Alyssa E., Beeson, James G., Cross, Nadia J., Drew, Damien R., Dutta, Sheetij, Elliott, Salenna R., Hodder, Anthony N., Marsh, Kevin, Mueller, Ivo, Mugyenyi, Cleopatra K., Osier, Faith, Richards, Jack S., Senn, Nicolas, Siba, Peter M., Stanisic, Danielle I., Terheggen, Ulrich   +16 more
core   +1 more source

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine–elicited human sera

Science, 2021
Vaccine protects against B1.1.7 variant The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B1.1.7 (VOC 202012/01) variant that emerged in late 2020 in the United Kingdom has many changes in the spike protein gene.
A. Muik, A. Wallisch, Bianca Sänger, K. Swanson, Julia Mühl, Wei Chen, Hui Cai, D. Maurus, Ritu Sarkar, Ö. Türeci, P. Dormitzer, U. Şahin   +11 more
semanticscholar   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source