Results 51 to 60 of about 857,892 (246)

Schmallenberg Virus: To Vaccinate, or Not to Vaccinate? [PDF]

Vaccines, 2020
Schmallenberg virus (SBV), a teratogenic orthobunyavirus that infects predominantly ruminants, emerged in 2011 in Central Europe, spread rapidly throughout the continent, and subsequently established an endemic status with re-circulations to a larger extent every 2 to 3 years.
Kerstin Wernike, Martin Beer
openaire   +4 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Vaccines

, 2013
Since vaccination was documented by Edward Jenner in 1798, it has become the most successful means of preventing infectious diseases, saving millions of lives every year. However, application of vaccines is currently not limited to the prevention of infectious diseases.
Jiskoot, W., Kersten, G.F.A., Mastrobattista, E.   +2 more
openaire   +4 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

COVID-19 vaccine acceptance and hesitancy in low- and middle-income countries

Nature Network Boston, 2021
Widespread acceptance of COVID-19 vaccines is crucial for achieving sufficient immunization coverage to end the global pandemic, yet few studies have investigated COVID-19 vaccination attitudes in lower-income countries, where large-scale vaccination is ...
Julio S Solís Arce, Shana S. Warren, N. Meriggi, Alexandra Scacco, Nina McMurry, M. Voors, Georgiy Syunyaev, A. Malik, Samya Aboutajdine, Opeyemi Adeojo, Deborah Anigo, A. Armand, S. Asad, Martin Atyera, Britta Augsburg, M. Awasthi, Gloria Eden Ayesiga, Antonella Bancalari, Martina Björkman Nyqvist, E. Borisova, C. M. Bosancianu, Magarita Rosa Cabra García, A. Cheema, Elliott Collins, Filippo Cuccaro, A. Farooqi, Tatheer Fatima, M. Fracchia, Mery Len Galindo Soria, Andrea Guariso, A. Hasanain, Sofía Jaramillo, Sellu Kallon, Anthony Kamwesigye, Arjun Kharel, S. Kreps, Madison Levine, Rebecca Littman, M. Malik, Gisele Manirabaruta, Jean Léodomir Habarimana Mfura, Fatoma Momoh, Alberto Mucauque, Imamo Mussa, J. Nsabimana, Isaac Obara, María Juliana Otálora, Béchir Ouédraogo, Touba Bakary Pare, Melina R. Platas, Laura Polanco, Javaeria Qureshi, Mariam Raheem, V. Ramakrishna, Ismail Rendrá, T. Shah, Sarene Eyla Shaked, Jacob N. Shapiro, J. Svensson, Ahsan Tariq, Achille Mignondo Tchibozo, Hamid Ali Tiwana, Bhartendu Trivedi, Corey Vernot, Pedro C. Vicente, Laurin B. Weissinger, basit. zafar, Baobao Zhang, Dean S. Karlan, M. Callen, Matthieu Teachout, M. Humphreys, A. Mobarak, S. Omer   +73 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

To vaccinate or not to vaccinate? The role of personality

Personality and Individual Differences, 2023
This article presents findings on the personality traits of individuals who identified as either Vaxxers (V) or Anti-Vaxxers (AV) during the COVID-19 pandemic. The study administered measures of Dark Triad traits (Machiavellianism, Narcissism, and Psychopathy), trait emotional intelligence, and personality to a sample of 479 participants (283 Vs and ...
Ngo, A, Petrides, KV, Vernon, PA
openaire   +3 more sources

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Safety and Efficacy of NVX-CoV2373 Covid-19 Vaccine

New England Journal of Medicine, 2021
Background Early clinical data from studies of the NVX-CoV2373 vaccine (Novavax), a recombinant nanoparticle vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that contains the full-length spike glycoprotein of the prototype ...
P. Heath, E. Galiza, D. Baxter, M. Boffito, D. Browne, Fiona Burns, D. Chadwick, R. Clark, C. Cosgrove, J. Galloway, A. Goodman, Amardeep Heer, A. Higham, Shalini Iyengar, A. Jamal, Christopher Jeanes, P. Kalra, Christina Kyriakidou, D. McAuley, Agnieszka Meyrick, A. Minassian, J. Minton, P. Moore, Imrozia Munsoor, Helen Nicholls, O. Osanlou, J. Packham, Carol H. Pretswell, Alberto San Francisco Ramos, D. Saralaya, R. Sheridan, Richard Smith, R. Soiza, P. Swift, E. Thomson, J. Turner, M. E. Viljoen, G. Albert, I. Cho, F. Dubovsky, G. Glenn, J. Rivers, A. Robertson, Kathy Smith, S. Toback   +44 more
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source