Results 71 to 80 of about 2,182,415 (399)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Vaccines and Vaccination

, 2015
Livestock vaccines aim to increase livestock product and improve the health and welfare of livestock animals in a cost-efficient manner and prevent disease transmission. Successful livestock vaccines have been generated for pathogens including bacterial, viral, protozoan, and multicellular pathogens.
openaire   +3 more sources

Neutrophil killing of Staphylococcus aureus in diabetes, obesity and metabolic syndrome: a prospective cellular surveillance study

Diabetology & Metabolic Syndrome, 2017
Background Obesity, metabolic syndrome (MetS), and diabetes are frequent in surgical populations and can enhance susceptibility to postoperative surgical site infections.
Ingrid Lea Scully, Lisa Kristin McNeil, Sudam Pathirana, Christine Lee Singer, Yongdong Liu, Stanley Mullen, Douglas Girgenti, Alejandra Gurtman, Michael W. Pride, Kathrin Ute Jansen, Paul L. Huang, Annaliesa S. Anderson   +11 more
doaj   +1 more source

Safety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine

New England Journal of Medicine, 2022
Background Active immunization with the BNT162b2 vaccine (Pfizer–BioNTech) has been a critical mitigation tool against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the coronavirus disease 2019 (Covid-19) pandemic.
E. Moreira, N. Kitchin, Xia Xu, S. Dychter, S. Lockhart, A. Gurtman, John L. Perez, C. Zerbini, Michael E. Dever, Timothy W Jennings, Donald M Brandon, Kevin D Cannon, M. Koren, D. Denham, M. Berhe, D. Fitz-Patrick, L. Hammitt, N. Klein, H. Nell, Georgina Keep, Xingbin Wang, K. Koury, K. Swanson, David Cooper, Claire Lu, Ö. Türeci, E. Lagkadinou, D. Tresnan, P. Dormitzer, U. Şahin, W. Gruber, K. Jansen   +31 more
semanticscholar   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Occurrence of human infection with Salmonella Typhi in sub-Saharan Africa

Scientific Data
Typhoid fever, caused by Salmonella enterica serovar Typhi, results in over 1.2 million cases and 29 thousand deaths annually from sub-Saharan Africa. Combating this disease requires various intervention approaches, such as typhoid conjugate vaccines and
Jong-Hoon Kim, Prerana Parajulee, Thuy Tien Nguyen, Shreeya Wasunkar, Vittal Mogasale, Se Eun Park, Ursula Panzner, Ondari D. Mogeni, Justin Im, Florian Marks   +9 more
doaj   +1 more source

Paperless registration during survey enumerations and large oral cholera mass vaccination in Zanzibar, the United Republic of Tanzania

Bulletin of the World Health Organization
PROBLEM: Field trials require extensive data preparation and complex logistics. The use of personal digital assistants (PDAs) can bypass many of the traditional steps that are necessary in a paper-based data entry system.
Mohammad Ali, Jaqueline L Deen, Ahmed Khatib, Godwin Enwere, Lorenz von Seidlein, Rita Reyburn, Said Mohammed Ali, Na Yoon Chang, Valérie Perroud, Frédérique Marodon, Abdul A Saleh, R Hashim, Anna Lena Lopez, James Beard, Benedikt N Ley, Kamala Thriemer, Mahesh K Puri, Binod Sah, Mohamed Saleh Jiddawi, John D Clemens   +19 more
doaj   +1 more source

Lipid nanoparticle-mediated lymph node–targeting delivery of mRNA cancer vaccine elicits robust CD8+ T cell response

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Current messenger RNA (mRNA) vaccines in the clinic were reported to induce side effects in the liver, such as reversible hepatic damages and T cell–dominant immune-mediated hepatitis, which might be caused by the undesired expression of ...
Jinjin Chen, Zhongfeng Ye, Changfeng Huang, Min Qiu, Donghui Song, Yamin Li, Qiaobing Xu   +6 more
semanticscholar   +1 more source

The Humoral Immunity Response of Dog Vaccinated with Oral Sag2 and Parenteral Rabisin and Rabivet Supra92 [PDF]

, 2012
This research aims to determine whether SAG2 oral vaccine induced antibody response as high as that of parenteral vaccine (Rabisin and Rabivet Supra 92).
Faizah, F. (Faizah), Mantik-Astawa, I. (IN), Putra, A. (AAG), Suwarno, S. (Suwarno)   +3 more
core  

Vaccines in Current Culture: The HPV Vaccine Controversy [PDF]

, 2020
The use of vaccinations has drastically decreased mortality and morbidity rates related to infectious disease and has become an intrinsic part of modern health care.
Johnston, Alyssa
core   +1 more source