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Polysaccharides as vaccine adjuvants
Vaccine, 2018Adjuvant is a substance added to vaccine to improve the immunogenicity of antigens, and it can induce stronger immune responses and reduce the dosage and production cost of vaccine in populations responding poorly to vaccination. Adjuvants in development or in use mainly include aluminum salts, oil emulsions, saponins, immune-stimulating complexes ...
Beini, Sun +5 more
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Immunology of Vaccine Adjuvants
2009In recent times vaccine adjuvants, or immunopotentiators, received abundant attention in the media as critical ingredients of current and future vaccines. Indeed, vaccine adjuvants are recognized to make the difference between competing vaccines based on identical antigens.
Ribeiro, C.M.S., Schijns, V.E.J.C.
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Adjuvants for malaria vaccines
Parasite Immunology, 2009SummaryThere is a renewed enthusiasm about subunit vaccines for malaria coincident with the formation of new alliances and partnerships raising international public awareness, attracting increased resources and the re‐focusing of research programs on adjuvant development for infectious disease vaccines.
R N, Coler +3 more
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Clinical Infectious Diseases, 1980
Nonreplicating, purified subunit or synthetic viral vaccines of the future are likely to be weak immunogens that will require immunopotentiation if they are to be effective. These marginal vaccines could be improved by combination with potent and safe immunologic adjuvants. The use of adjuvants should also reduce the amount of purified antigen required
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Nonreplicating, purified subunit or synthetic viral vaccines of the future are likely to be weak immunogens that will require immunopotentiation if they are to be effective. These marginal vaccines could be improved by combination with potent and safe immunologic adjuvants. The use of adjuvants should also reduce the amount of purified antigen required
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Seminars in Veterinary Medicine and Surgery: Small Animal, 1997
Vaccine adjuvants provide enhanced immune responses to a variety of antigens. Unlike human vaccines that are limited to aluminum-based adjuvants, veterinary vaccines may contain a large number of substances either alone or in combination that act as vaccine adjuvants.
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Vaccine adjuvants provide enhanced immune responses to a variety of antigens. Unlike human vaccines that are limited to aluminum-based adjuvants, veterinary vaccines may contain a large number of substances either alone or in combination that act as vaccine adjuvants.
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The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine
Vaccine, 2001Elderly people and subjects with underlying chronic diseases are at increased risk for influenza and related complications. Conventional influenza vaccines provide only limited protection in the elderly population. In order to enhance the immune response to influenza vaccines, several adjuvants have been evaluated. Among these, an oil in water adjuvant
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Adjuvants in influenza vaccines
Vaccine, 2012The effectiveness of influenza vaccines is still controversial, and the role of adjuvants in such vaccines is briefly reviewed in this paper. Inactivated whole virus vaccines may include components that function as adjuvants, meaning that additive adjuvants are often not required. MF59 and AS03 showed higher adjuvanticity than aluminum salts in several
Kohhei, Tetsutani, Ken J, Ishii
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Vaccine, 2007
The development of new adjuvants for human vaccines has become an expanding field of research in the last thirty years, for generating stronger vaccines capable of inducing protective and long-lasting immunity in humans. Instead of such efforts, with several adjuvant strategies approaching to requirements for their clinical application, limitations ...
J C, Aguilar, E G, Rodríguez
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The development of new adjuvants for human vaccines has become an expanding field of research in the last thirty years, for generating stronger vaccines capable of inducing protective and long-lasting immunity in humans. Instead of such efforts, with several adjuvant strategies approaching to requirements for their clinical application, limitations ...
J C, Aguilar, E G, Rodríguez
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Adjuvants for vaccines, a quest
International Immunopharmacology, 2003Efficient vaccines comprise a specific moiety: the structures presenting the protective antigenic determinants, and a nonspecific moiety: the adjuvant components. Dramatic advances have been reported concerning the specific moiety and new and highly purified immunogens have been defined and prepared.
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Current Opinion in HIV and AIDS, 2016
Advances in the understanding of the structural biology of HIV-1 proteins, and in the vulnerabilities of HIV-1 at various points in the infectious process have led to innovative approaches for vaccine constructs for clinical trials. Lessons from the successful Retrovirology study 144 (RV144) phase III Thai trial have revealed the need for novel and ...
Mangala, Rao, Carl R, Alving
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Advances in the understanding of the structural biology of HIV-1 proteins, and in the vulnerabilities of HIV-1 at various points in the infectious process have led to innovative approaches for vaccine constructs for clinical trials. Lessons from the successful Retrovirology study 144 (RV144) phase III Thai trial have revealed the need for novel and ...
Mangala, Rao, Carl R, Alving
openaire +2 more sources