Results 41 to 50 of about 545,826 (308)

Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity

Frontiers in Nutrition, 2019
Vitamins are micronutrients that have physiological effects on various biological responses, including host immunity. Therefore, vitamin deficiency leads to increased risk of developing infectious, allergic, and inflammatory diseases.
Ken Yoshii, Ken Yoshii, Koji Hosomi, Kento Sawane, Kento Sawane, Kento Sawane, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +11 more
doaj   +1 more source

C-type lectin receptor agonists elicit functional IL21-expressing Tfh cells and induce primary B cell responses in neonates

Frontiers in Immunology, 2023
IntroductionC-type lectin receptor (CLR) agonists emerged as superior inducers of primary B cell responses in early life compared with Toll-like receptor (TLR) agonists, while both types of adjuvants are potent in adults.MethodsHere, we explored the ...
Maria Vono, Beatris Mastelic-Gavillet, Elodie Mohr, Malin Östensson, Josefine Persson, Thorunn A. Olafsdottir, Sylvain Lemeille, David Pejoski, Oliver Hartley, Dennis Christensen, Peter Andersen, Arnaud M. Didierlaurent, Ali M. Harandi, Ali M. Harandi, Paul-Henri Lambert, Claire-Anne Siegrist   +15 more
doaj   +1 more source

Lymphoid Tissue–Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells

Frontiers in Microbiology, 2020
Lymphoid-tissue–resident commensal bacteria (LRCs), including Alcaligenes faecalis, are present in intestinal lymphoid tissue including the Peyer’s patches (PPs) of mammals and modulate the host immune system.
Koji Hosomi, Koji Hosomi, Naoko Shibata, Naoko Shibata, Naoko Shibata, Naoko Shibata, Atsushi Shimoyama, Tomoya Uto, Takahiro Nagatake, Takahiro Nagatake, Yoko Tojima, Yoko Tojima, Tomomi Nishino, Tomomi Nishino, Haruko Takeyama, Haruko Takeyama, Koichi Fukase, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +31 more
doaj   +1 more source

Immune Enhancement by the Tetra-Peptide Hydrogel as a Promising Adjuvant for an H7N9 Vaccine against Highly Pathogenic H7N9 Virus

Vaccines, 2022
Background: Short peptide hydrogel was reported as a possible adjuvant for vaccines. In order to evaluate whether the Tetra-Peptide Hydrogel can be a promising adjuvant for an H7N9 vaccine against the highly pathogenic H7N9 virus, we conducted this study.
Xiaoxin Wu, Songjia Tang, Zhehua Wang, Xiaoyun Ma, Lingjian Zhang, Fen Zhang, Lanlan Xiao, Shuai Zhao, Qian Li, Ying Wang, Qingjing Wang, Keda Chen   +11 more
doaj   +1 more source

Adjuvanted influenza vaccines [PDF]

Human Vaccines & Immunotherapeutics, 2012
The search for adjuvants has been stimulated by the need to ensure greater protection against influenza among subjects who show a reduced immune response to conventional influenza vaccines. Aluminum salts have long been used but are not considered satisfactory.
N. Principi, Esposito, Susanna Maria Roberta   +1 more
openaire   +7 more sources

Vaccination with the surface proteins MUL_2232 and MUL_3720 of Mycobacterium ulcerans induces antibodies but fails to provide protection against Buruli ulcer [PDF]

, 2016
Buruli ulcer, caused by infection with Mycobacterium ulcerans, is a chronic ulcerative neglected tropical disease of the skin and subcutaneous tissue that is most prevalent in West African countries. M.
Miriam Bolz, Gerd Pluschke, Wulf Oehlmann, Malcolm S Duthie, Dreyer, Anita M., Sarah Kerber, Malcolm S. Duthie (231822), Duthie, Malcolm S., Andrea Vettiger, Wulf Oehlmann (332809), Mahavir Singh, Singh, Mahavir, Sarah Kerber (421868), Mahavir Singh (70735), Oehlmann, Wulf, Anita M. Dreyer (2154052), Andrea Vettiger (436255), Kerber, Sarah, Bolz, Miriam, Miriam Bolz (309717), Vettiger, Andrea, Angèle Bénard (238312), Bénard, Angèle, Anita M Dreyer, Angèle Bénard, Gerd Pluschke (7855), Pluschke, Gerd   +26 more
core   +2 more sources

Vitamin B1 Supports the Differentiation of T Cells through TGF-β Superfamily Production in Thymic Stromal Cells

iScience, 2020
Summary: Homeostatic generation of T cells, which occurs in the thymus, is controlled at least in part by endogenous cytokines and ligands. In addition, nutritional factors are other key regulators for the homeostasis of host immunity, but whether and ...
So-ichiro Hirata, Kento Sawane, Jun Adachi, Junko Isoyama, Yuki Sugiura, Ayu Matsunaga, Koji Hosomi, Takeshi Tomonaga, Makoto Suematsu, Takahiro Nagatake, Jun Kunisawa   +10 more
doaj   +1 more source

Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein

Scientific Reports, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Variants of concern (VOCs) such as Delta and Omicron have developed, which continue to spread the pandemic.
Ryota Otsubo, Takeharu Minamitani, Kouji Kobiyama, Junso Fujita, Toshihiro Ito, Shiori Ueno, Itsuki Anzai, Hiroki Tanino, Hiroshi Aoyama, Yoshiharu Matsuura, Keiichi Namba, Ken-Ichi Imadome, Ken J. Ishii, Kouhei Tsumoto, Wataru Kamitani, Teruhito Yasui   +15 more
doaj   +1 more source

Adenovirus Encoded Adjuvant (AdEnA) anti-CTLA-4, a novel strategy to improve Adenovirus based vaccines against infectious diseases and cancer

Frontiers in Immunology, 2023
IntroductionVirus vectored genetic vaccines (Vvgv) represent a promising approach for eliciting immune protection against infectious diseases and cancer.
Anna Morena D’Alise, Linda Nocchi, Irene Garzia, Laura Seclì, Luigia Infante, Fulvia Troise, Gabriella Cotugno, Simona Allocca, Giuseppina Romano, Armin Lahm, Guido Leoni, Emanuele Sasso, Emanuele Sasso, Elisa Scarselli, Alfredo Nicosia, Alfredo Nicosia   +15 more
doaj   +1 more source

Effect of incorporating different concentrations of palm oil as adjuvant in fish vaccine [PDF]

, 2018
Adjuvants play important role in vaccine efficacy due to the slow release that leads to prolong immune response. This study determines the advantage of palm oil as adjuvant in the newly developed feed-based killed vaccine against streptococcosis.
Hashim, Shahidan, Sulaiman, Suphia Amiera, Abdullah, Siti Zahrah, Sudirwan, Fahmi, Mohd Yusof, Hanan, Mustaffa Kamal, Farina, Ridzuan, Mohd Syafiq, Aminudin, Sa’aidatun Asyikin, Saad, Mohd Zamri, Md. Salihin, Ismail   +9 more
core   +1 more source