Results 41 to 50 of about 596,848 (310)

Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity

Frontiers in Nutrition, 2019
Vitamins are micronutrients that have physiological effects on various biological responses, including host immunity. Therefore, vitamin deficiency leads to increased risk of developing infectious, allergic, and inflammatory diseases.
Ken Yoshii, Ken Yoshii, Koji Hosomi, Kento Sawane, Kento Sawane, Kento Sawane, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +11 more
doaj   +1 more source

C-type lectin receptor agonists elicit functional IL21-expressing Tfh cells and induce primary B cell responses in neonates

Frontiers in Immunology, 2023
IntroductionC-type lectin receptor (CLR) agonists emerged as superior inducers of primary B cell responses in early life compared with Toll-like receptor (TLR) agonists, while both types of adjuvants are potent in adults.MethodsHere, we explored the ...
Maria Vono, Beatris Mastelic-Gavillet, Elodie Mohr, Malin Östensson, Josefine Persson, Thorunn A. Olafsdottir, Sylvain Lemeille, David Pejoski, Oliver Hartley, Dennis Christensen, Peter Andersen, Arnaud M. Didierlaurent, Ali M. Harandi, Ali M. Harandi, Paul-Henri Lambert, Claire-Anne Siegrist   +15 more
doaj   +1 more source

Lymphoid Tissue–Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells

Frontiers in Microbiology, 2020
Lymphoid-tissue–resident commensal bacteria (LRCs), including Alcaligenes faecalis, are present in intestinal lymphoid tissue including the Peyer’s patches (PPs) of mammals and modulate the host immune system.
Koji Hosomi, Koji Hosomi, Naoko Shibata, Naoko Shibata, Naoko Shibata, Naoko Shibata, Atsushi Shimoyama, Tomoya Uto, Takahiro Nagatake, Takahiro Nagatake, Yoko Tojima, Yoko Tojima, Tomomi Nishino, Tomomi Nishino, Haruko Takeyama, Haruko Takeyama, Koichi Fukase, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +31 more
doaj   +1 more source

Critical analysis of reference studies on the toxikinetics of aluminium-based adjuvants [PDF]

, 2018
We reviewed the three toxicokinetic reference studies commonly used to suggest that aluminum (Al)-based adjuvants are innocuous. A single experimental study was carried out using isotopic 26Al (Flarend et al., Vaccine, 1997).

core   +1 more source

Vitamin B1 Supports the Differentiation of T Cells through TGF-β Superfamily Production in Thymic Stromal Cells

iScience, 2020
Summary: Homeostatic generation of T cells, which occurs in the thymus, is controlled at least in part by endogenous cytokines and ligands. In addition, nutritional factors are other key regulators for the homeostasis of host immunity, but whether and ...
So-ichiro Hirata, Kento Sawane, Jun Adachi, Junko Isoyama, Yuki Sugiura, Ayu Matsunaga, Koji Hosomi, Takeshi Tomonaga, Makoto Suematsu, Takahiro Nagatake, Jun Kunisawa   +10 more
doaj   +1 more source

Human antibody recognition and neutralization mode on the NTD and RBD domains of SARS-CoV-2 spike protein

Scientific Reports, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Variants of concern (VOCs) such as Delta and Omicron have developed, which continue to spread the pandemic.
Ryota Otsubo, Takeharu Minamitani, Kouji Kobiyama, Junso Fujita, Toshihiro Ito, Shiori Ueno, Itsuki Anzai, Hiroki Tanino, Hiroshi Aoyama, Yoshiharu Matsuura, Keiichi Namba, Ken-Ichi Imadome, Ken J. Ishii, Kouhei Tsumoto, Wataru Kamitani, Teruhito Yasui   +15 more
doaj   +1 more source

Adenovirus Encoded Adjuvant (AdEnA) anti-CTLA-4, a novel strategy to improve Adenovirus based vaccines against infectious diseases and cancer

Frontiers in Immunology, 2023
IntroductionVirus vectored genetic vaccines (Vvgv) represent a promising approach for eliciting immune protection against infectious diseases and cancer.
Anna Morena D’Alise, Linda Nocchi, Irene Garzia, Laura Seclì, Luigia Infante, Fulvia Troise, Gabriella Cotugno, Simona Allocca, Giuseppina Romano, Armin Lahm, Guido Leoni, Emanuele Sasso, Emanuele Sasso, Elisa Scarselli, Alfredo Nicosia, Alfredo Nicosia   +15 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Carbonate Apatite Nanoparticles Act as Potent Vaccine Adjuvant Delivery Vehicles by Enhancing Cytokine Production Induced by Encapsulated Cytosine-Phosphate-Guanine Oligodeoxynucleotides

Frontiers in Immunology, 2018
Vaccine adjuvants that can induce not only antigen-specific antibody responses but also Th1-type immune responses and CD8+ cytotoxic T lymphocyte responses are needed for the development of vaccines against infectious diseases and cancer.
Hideki Takahashi, Kazuki Misato, Taiki Aoshi, Taiki Aoshi, Yasuyuki Yamamoto, Yui Kubota, Xin Wu, Etsushi Kuroda, Etsushi Kuroda, Ken J. Ishii, Ken J. Ishii, Hirofumi Yamamoto, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka   +15 more
doaj   +1 more source

Effect of incorporating different concentrations of palm oil as adjuvant in fish vaccine [PDF]

, 2018
Adjuvants play important role in vaccine efficacy due to the slow release that leads to prolong immune response. This study determines the advantage of palm oil as adjuvant in the newly developed feed-based killed vaccine against streptococcosis.
Hashim, Shahidan, Sulaiman, Suphia Amiera, Abdullah, Siti Zahrah, Sudirwan, Fahmi, Mohd Yusof, Hanan, Mustaffa Kamal, Farina, Ridzuan, Mohd Syafiq, Aminudin, Sa’aidatun Asyikin, Saad, Mohd Zamri, Md. Salihin, Ismail   +9 more
core   +1 more source