Results 21 to 30 of about 545,826 (308)

Enzymatically synthesized exopolysaccharide of a probiotic strain Leuconostoc mesenteroides NTM048 shows adjuvant activity to promote IgA antibody responses

Gut Microbes, 2021
Leuconostoc mesenteroides strain NTM048 produces an exopolysaccharide (EPS; glucose polymers 94% and fructose polymers 6%) with adjuvanticity for mucosal vaccination.
Chiaki Matsuzaki, Yukari Nakashima, Ikuto Endo, Yusuke Tomabechi, Yasuki Higashimura, Saki Itonori, Koji Hosomi, Jun Kunisawa, Kenji Yamamoto, Keiko Hisa   +9 more
doaj   +1 more source

Assessment of Fcγ receptor-dependent binding of influenza hemagglutinin vaccine-induced antibodies in a non-human primate model

iScience, 2022
Summary: Several cross-protective antibodies that recognize a broad range of influenza A virus (IAV) strains are known to have functions in virus elimination such as Fcγ receptor (FcγR)-effector function and neutralizing activity against the head region.
Yuji Masuta, Shokichi Takahama, Takuto Nogimori, Saya Moriyama, Yoshimasa Takahashi, Takuya Yamamoto   +5 more
doaj   +1 more source

Protective antiviral immune responses to pseudorabies virus induced by DNA vaccination using dimethyldioctadecylammonium bromide as an adjuvant [PDF]

, 2002
To enhance the efficacy of a DNA vaccine against pseudorabies virus (PRV), we evaluated the adjuvant properties of plasmids coding for gamma interferon or interleukin-12, of CpG immunostimulatory motifs, and of the conventional adjuvants ...
Eddie G. te Lintelo, te Lintelo, E.G., Wim J. A. Boersma, Rooij, E.M.A., van, Yolanda E. de Visser, Boersma, WJA, Lintelo, E.G., te, Boersma, W.J.A., Visser, Y.E., de, Hilgers, LAT, Haagmans, Bart, van Rooij, EMA, Bart L. Haagmans, Bianchi, ATJ, Harrie L. Glansbeek, Hilgers, L.A.T., Haagmans, B.L., Glansbeek, H.L., Andre T. J. Bianchi, van Rooij, E.M.A., Glansbeek, HL, Eugene M. A. van Rooij, de Visser, Y.E., Luuk A. T. Hilgers, Bianchi, A.T.J., Lintelo, EG, de Visser, YE   +26 more
core   +1 more source

The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant [PDF]

, 2013
5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a potent type I interferon (IFN) inducer, was evaluated as a chemotherapeutic agent in mouse cancer models and proved to be well tolerated in human cancer clinical trials.
Cevayir Coban, Kenji Mizuguchi, Junichi Ito, Etsushi Kuroda, Coban, C, Ishii, KJ, Choon Kit Tang, Shizuo Akira, Jounai, N, Benoit H Dessailly, Ito, J, Keiichi Ohata, Tang, CK, Akira, S, Mizuguchi, K, Ken J Ishii, Kouji Kobiyama, Ohata, K, Nao Jounai, Kuroda, E, Kobiyama, K, Dessailly, BH, Aoshi, T, Taiki Aoshi   +23 more
core   +1 more source

Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor

Frontiers in Immunology, 2019
Extracellular host-derived DNA, as one of damage associated molecular patterns (DAMPs), is associated with allergic type 2 immune responses. Immune recognition of such DNA generates the second messenger cyclic GMP-AMP (cGAMP) and induces type-2 immune ...
Koji Ozasa, Koji Ozasa, Burcu Temizoz, Burcu Temizoz, Burcu Temizoz, Burcu Temizoz, Takato Kusakabe, Takato Kusakabe, Takato Kusakabe, Shingo Kobari, Shingo Kobari, Masatoshi Momota, Masatoshi Momota, Cevayir Coban, Cevayir Coban, Cevayir Coban, Shuichi Ito, Kouji Kobiyama, Kouji Kobiyama, Kouji Kobiyama, Kouji Kobiyama, Etsushi Kuroda, Etsushi Kuroda, Etsushi Kuroda, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +28 more
doaj   +1 more source

Machine Learning-Assisted Screening of Herbal Medicine Extracts as Vaccine Adjuvants

Frontiers in Immunology, 2022
Adjuvants are important vaccine components, composed of a variety of chemical and biological materials that enhance the vaccine antigen-specific immune responses by stimulating the innate immune cells in both direct and indirect manners to produce a ...
Kou Hioki, Kou Hioki, Tomoya Hayashi, Tomoya Hayashi, Yayoi Natsume-Kitatani, Kouji Kobiyama, Kouji Kobiyama, Burcu Temizoz, Burcu Temizoz, Hideo Negishi, Hitomi Kawakami, Hiroyuki Fuchino, Etsushi Kuroda, Cevayir Coban, Cevayir Coban, Nobuo Kawahara, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +18 more
doaj   +1 more source

Dendritic cell proliferation by primary cilium in atopic dermatitis

Frontiers in Molecular Biosciences, 2023
Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama, Manami Toriyama, Manami Toriyama, Defri Rizaldy, Defri Rizaldy, Defri Rizaldy, Motoki Nakamura, Motoki Nakamura, Yukiko Atsumi, Yukiko Atsumi, Michinori Toriyama, Fumitaka Fujita, Fumitaka Fujita, Fumitaka Fujita, Fumihiro Okada, Fumihiro Okada, Akimichi Morita, Hiroshi Itoh, Ken J. Ishii, Ken J. Ishii   +19 more
doaj   +1 more source

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin. [PDF]

, 2009
BACKGROUND: An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT ...
Kromann Ingrid, Woodrow, M, Novicki Deborah, Huo, Z, Del Giudice Giuseppe, Novicki, D, Rappuoli Rino, Thierry-Carstensen, B, Susan Barnett, Galiza, E, David J M Lewis, Rafaela Giemza, Andersen, P, Peter Andersen, Lewis David J. M., Barnett Susan, Maria Woodrow, Kromann, I, Giuseppe Del Giudice, Thierry-Carstensen Birgit, Giemza Rafaela, Ingrid Kromann, Andersen Peter, Lewis, DJ, Galiza Eva, Giemza, R, Huo Zhiming, Woodrow Maria, Deborah Novicki, Eva Galiza, Birgit Thierry-Carstensen, Rino Rappuoli, Del Giudice, G, Rappuoli, R, Barnett, S, Zhiming Huo   +35 more
core   +1 more source

Adjuvants : an essential component of neisseria vaccines [PDF]

, 2009
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis ...
Acevedo, R., del Campo, J., Zayas, C., Cuello, M., Romeu, B., Ferro, Valerie A., Gonzales, E., Cabrera, O., Balbao, J.   +8 more
core   +4 more sources

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Frontiers in Immunology, 2018
Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing host ...
Tomoya Hayashi, Tomoya Hayashi, Masatoshi Momota, Masatoshi Momota, Etsushi Kuroda, Etsushi Kuroda, Takato Kusakabe, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S. J. Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J. Ishii, Ken J. Ishii, Hidetoshi Arima, Hidetoshi Arima   +22 more
doaj   +1 more source