Results 31 to 40 of about 86,997 (265)

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, EarlyView.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Rational design of HIV vaccine and microbicides: report of the EUROPRISE annual conference. [PDF]

, 2010
EUROPRISE is a Network of Excellence sponsored from 2007 to 2011 by the European Commission within the 6th Framework Program. The Network encompasses a wide portfolio of activities ranging from an integrated research program in the field of HIV vaccines ...
Palma, Paolo, Palma Paolo, Lara Mainetti, Paolo Palma, Grupping, K., Reudelsterz, M., Robin Shattock, Hannes Uchtenhagen, Gabriella Scarlatti, Hallengärd, D, Uchtenhagen, H, Hallengärd David, Shattock Robin, Caroline Weber, Mainetti, Lara, Wahren, Britta, Winni De Haes, Coleman, A., Annette Sköld, Seifried, Janna, Sköld, A, Sköld Annette, Scarlatti, G, Lund University., Selhorst, P., Hornig Julia, van Gils, M. J., De Haes, W., Hornig, Julia, De Haes, W, Klein, K., Seifried Janna, Biswas, P., Da Costa, K., Da Costa Kelly, Da Costa, K, De Haes, Winni, Dieltjens Tessa, Wahren, B., Reudelsterz, Marc, Palma, P., Borggren, Marie,, Dispinseri Stefania, Seifried, J., Uchtenhagen, Hannes, Hornig, J., Borggren, Marie, Da Costa, Kelly, Scarlatti Gabriella, Selhorst, P, Wahren, B, Selhorst Philippe, David Hallengärd, Kelly Da Costa, Katrijn Grupping, Priscilla Biswas, Shattock, R., Katja Klein, Mainetti Lara, Mainetti, L., Janna Seifried, Dieltjens, Tessa, Scarlatti, Gabriella, Klein Katja, Marit J van Gils, Weber, Caroline, Weber, C, De Haes Winni, Uchtenhagen Hannes, Grupping Katrijn, van Gils, M.J., Borggren Marie, Adam Coleman, Weber Caroline, Shattock, R, Hornig, J, van Gils Marit J, Marie Borggren, Borggren, M, Selhorst, Philippe, Costa, Kelly Da, Mainetti, L, Skold, A., Biswas, P, Coleman, Adam, Coleman, A, Stefania Dispinseri, Gils, Marit J. van, Palma, P, Wahren Britta, Marc Reudelsterz, Hallengard, David, Seifried, J, Haes, Winni De, van Gils, MJ, Weber, C., Scarlatti, G., Philippe Selhorst, Biswas Priscilla, Reudelsterz, M, van Gils, Marit J., Klein, K, Hallengard, D., Britta Wahren, Tessa Dieltjens, Borggren, M., Dieltjens, T., Coleman Adam, Grupping, K, Biswas, Priscilla, Skold, Annette, Grupping, Katrijn, Dispinseri, S., Dieltjens, T, Dispinseri, S, Klein, Katja, Reudelsterz Marc, Julia Hornig, Dispinseri, Stefania, Shattock, Robin   +119 more
core   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Digitally Enabled Generic Analytical Framework Accelerating the Pace of Liquid Chromatography Method Development for Vaccine Adjuvant Formulations. [PDF]

ACS Pharmacol Transl Sci
The growing use of adjuvants in the fast-paced formulation of new vaccines has created an unprecedented need for meaningful analytical assays that deliver reliable quantitative data from complex adjuvant and adjuvant-antigen mixtures.
Hemida M, Barrientos RC, Kinsey C, Kuster N, Bhavsar M, Beck AG, Wang H, Singh A, Aggarwal P, Arcinas A, Mukherjee M, Appiah-Amponsah E, Regalado EL.   +12 more
europepmc   +2 more sources

Laser adjuvant for vaccination

The FASEB Journal, 2020
Abstract The use of an immunologic adjuvant to augment the immune response is essential for modern vaccines which are relatively ineffective on their own. In the past decade, researchers have been consistently reporting that skin treatment with a physical parameter, namely laser light, augments the immune response to vaccine and ...
openaire   +3 more sources

A Phase I, randomized, open-label study to evaluate the safety and immunogenicity of an enterovirus 71 vaccine

, 2013
[[abstract]]AbstractBackground Large-scale outbreaks of enterovirus 71 (EV71) infections have occurred in Asia-Pacific regions. Severe complications include encephalitis and poliomyelitis-like paralysis, cardiopulmonary collapse, and death, necessitating
Cheng, A;Fung, CP;Liu, CC;Lin, YT;Tsai, HY;Chang, SC;Chou, AH;Chang, JY;Jiang, RH;Hsieh, YC;Su, IJ;Chong, PCS;Hsieh, SM
core   +1 more source

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]

, 2008
Alum is used as a vaccine adjuvant and induces T_h2 responses and T_h2-driven antibody isotype production against co-injected antigens.
White, Janice, Kappler, John W., McKee, Amy S., Marrack, Philippa, Macleod, Megan, P. Marrack, J. White, J. W. Kappler, F. Crawford, A. S. McKee, M. MacLeod, Crawford, Frances   +11 more
core   +1 more source