Results 11 to 20 of about 545,826 (308)

Overcoming Aging-Associated Poor Influenza Vaccine Responses with CpG 1018 Adjuvant [PDF]

Vaccines, 2022
Aging is associated with diminished immune system function, which renders old people vulnerable to influenza infection and also less responsive to influenza vaccination.
Xinliang Kang, Yibo Li, Yiwen Zhao, Xinyuan Chen   +3 more
doaj   +2 more sources

CpG-DNA enhancement the immune elicited as adjuvant of foot- and- mouth disease vaccine

Archives of Razi Institute, 2010
In the present study the effect of the locally produced genetic adjuvant of ginea pig specific CpG-motif-containing oligodeoxynucleotide (CpG-ODN) in an inactivated FMD virus vaccine was evaluated.
Morshedi, A., Daghighi, M., Mahravani, H.   +2 more
doaj   +1 more source

Bacterial outer membrane vesicles and vaccine applications [PDF]

, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Sarmiento, Maria Elena, Campa, Concepcion, Fernandez, Sonsire, Garcia, Luis, Cardoso, Daniel, Zayas, Caridad, Rosenqvist, Einar, Ferro, Valerie, Acosta, Armando, Acevedo, Reinaldo, Perez, Jose Luis   +10 more
core   +4 more sources

Primary Cilia in the Skin: Functions in Immunity and Therapeutic Potential

Frontiers in Cell and Developmental Biology, 2021
The skin is the biggest organ and provides a physical and immunological barrier against pathogen infection. The distribution of primary cilia in the skin of mice has been reported, but which cells in human skin have them has not, and we still know very ...
Manami Toriyama, Manami Toriyama, Manami Toriyama, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +5 more
doaj   +1 more source

Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine

Vaccines, 2020
Alcaligenes spp. are identified as commensal bacteria and have been found to inhabit Peyer’s patches in the gut. We previously reported that Alcaligenes-derived lipopolysaccharides (LPS) exerted adjuvant activity in systemic vaccination, without ...
Yunru Wang, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Haruki Yamaura, Takahiro Nagatake, Tomomi Nishino, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa   +9 more
doaj   +1 more source

Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine

Frontiers in Pharmacology, 2021
We previously identified Alcaligenes spp. as a commensal bacterium that resides in lymphoid tissues, including Peyer’s patches. We found that Alcaligenes-derived lipopolysaccharide acted as a weak agonist of Toll-like receptor four due to the unique ...
Zilai Liu, Zilai Liu, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Ken Yoshii, Xiao Sun, Xiao Sun, Huangwenxian Lan, Huangwenxian Lan, Yunru Wang, Yunru Wang, Haruki Yamaura, Davie Kenneth, Azusa Saika, Azusa Saika, Takahiro Nagatake, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa, Jun Kunisawa   +30 more
doaj   +1 more source

17(S),18(R)‐epoxyeicosatetraenoic acid generated by cytochrome P450 BM‐3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G‐protein‐coupled receptor 40‐mediated neutrophil suppression

FASEB BioAdvances, 2020
Dietary intake of ω3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid is beneficial for health control. We recently identified 17,18‐epoxyeicosatetraenoic acid (17,18‐EpETE) as a lipid metabolite endogenously generated ...
Azusa Saika, Takahiro Nagatake, Shigenobu Kishino, Si‐Bum Park, Tetsuya Honda, Naomi Matsumoto, Michiko Shimojou, Sakiko Morimoto, Prabha Tiwari, Eri Node, So‐ichiro Hirata, Koji Hosomi, Kenji Kabashima, Jun Ogawa, Jun Kunisawa   +14 more
doaj   +1 more source

Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity

Microorganisms, 2020
Effective and safe vaccine adjuvants are needed to appropriately augment mucosal vaccine effects. Our previous study demonstrated that lipopolysaccharide (LPS) from Peyer’s patch resident Alcaligenes stimulated dendritic cells to promote the production ...
Ken Yoshii, Koji Hosomi, Atsushi Shimoyama, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Hidehiko Suzuki, Huangwenxian Lan, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa   +10 more
doaj   +1 more source

Adjuvants for human vaccines [PDF]

Current Opinion in Immunology, 2012
Rational selection of individual adjuvants can often be made on the basis of innate molecular interactions of the foreign molecules with pattern recognition receptors such as Toll-like receptors. For example, monophosphoryl lipid A, a family of endotoxic TLR4 agonist molecules from bacteria, has recently been formulated with liposomes, oil emulsions ...
Carl R, Alving, Kristina K, Peachman, Mangala, Rao, Steven G, Reed   +3 more
openaire   +2 more sources

Instillation of Particulate Suspensions to the Lungs

Bio-Protocol, 2017
Inhaled fine particulates are thought to cause chronic pulmonary inflammation through the deposition of particulates into the lungs. To investigate the effect of fine particulates on the lungs, instillation of suspension of particulates into the lungs is
Etsushi Kuroda, Yasuo Morimoto, Ken Ishii   +2 more
doaj   +1 more source