Results 111 to 120 of about 131,172 (214)

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, EarlyView.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions

Drug Design, Development and Therapy
Weiyi Xiang,1,2 Xian Jiang,1,2,* Linghong Guo1,2,* 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and ...
Xiang W, Jiang X, Guo L
doaj  

Novel approach for vaccine delivery using mRNA lipid nanoparticles for <i>in vivo</i> production of monoclonal antibodies. [PDF]

Mol Ther Nucleic Acids
Lundstrom K.
europepmc   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Advancing intradermal vaccine delivery: Focus on hollow microneedles and skin models. [PDF]

Hum Vaccin Immunother
Verbist W, Broeckhoven E, Vanwersch P, Shrirang Choudhari V, Van Hileghem L, Spasic D, Coelmont L, Evens T, Castagne S, Van Bael A, Dallmeier K, Lammertyn J.   +11 more
europepmc   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, EarlyView.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

Comparative Evaluation of Polymeric Nanocarriers for DNA Vaccine Delivery Against <i>Avian Orthoavulavirus 1</i> in Chickens. [PDF]

Viruses
Khattab AH, Bayoumi M, Eldin ZE, Ahmed BM, Amer HM.   +4 more
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Community engagement for vaccine delivery in low- and middle-income countries and humanitarian settings: A scoping umbrella review. [PDF]

PLOS Glob Public Health
Polonsky JA, Burns R, Odlum A, Hamza YA, Mulugeta Y, Abramowitz S, Enria L, Blanchet K.   +7 more
europepmc   +1 more source