Advanced Science, EarlyView.TRIM28 binds to DDX3 protein to catalyze the SUMOylation of DDX3 (S‐DDX3), thus the S‐DDX3 involves in aberrant alternative splicing of KLF4 mRNA, and the splicing variant KLF4α‐mediated cell cycle and signal transduction, weakens tumor suppressor function of DDX3 protein, which promotes progression of HBV‐HCC.
Yanfang Yang +8 more
wiley +1 more source
Multi-epitope vaccine design against Monkeypox virus: An immunoinformatics approach. [PDF]
PLoS OneAhmad S, Aslam S, Khalid A.
europepmc +1 more source
Ligand‐Ratio–Tuned DNA Nanocarriers Overcome Bladder Barriers for Ultralow‐Dose Intravesical Therapy
Advanced Science, EarlyView.A programmable DNA framework drug carrier coordinates barrier transport, tumor targeting, and drug delivery through ligand‐ratio engineering. Systematic exploration of the Sgc8/fluorocarbon design space reveals a nonlinear optimal balance between penetration and cellular engagement, translating multifunctional integration into durable bladder tumor ...
Dunfang Liu +5 more
wiley +1 more source
Discovery of KC-1: a novel porcine dendritic cell-targeting peptide with potential applications in swine vaccine design. [PDF]
BMC Vet ResLiu B +7 more
europepmc +1 more source
Spray‐Dried mRNA‐LNP Powder Enabling Multi‐Route Delivery With 3‐Year Refrigerated Stability
Advanced Science, EarlyView.Spray‐dried mRNA‐LNP powder with trehalose matrix enables reconstitution for parenteral delivery or direct administration via pulmonary and sublingual routes, maintaining protein expression comparable to liquid controls. The thermostable powder preserves colloidal stability, mRNA integrity, and biological activity for over 3 years at 2°C–8°C, while ...
Ashish Sarode +4 more
wiley +1 more source
Harnessing conserved epitopes and multivalent antigen strategies for vaccine design: Lessons learned and opportunities. [PDF]
Hum Vaccin ImmunotherAdjei-Gati E +6 more
europepmc +1 more source
Autonomous AI‐Driven Design for Skin Product Formulations
Advanced Intelligent Discovery, EarlyView.This review presents a comprehensive closed‐loop framework for autonomous skin product formulation design. By integrating artificial intelligence‐driven experiment selection with automated multi‐tiered assays, the approach shifts development from trial‐and‐error to intelligent optimisation.
Yu Zhang +5 more
wiley +1 more source
Brief Comparison of Novel Influenza Vaccine Design Strategies. [PDF]
Vaccines (Basel)Chai S, Ye C, Fan C, Jiang H.
europepmc +1 more source
American Journal of Agricultural Economics, EarlyView.Abstract Our general interest is in global trade loss from livestock pathogens, specifically exports. We adopt a causal inference approach that considers animal disease outbreaks over time as non‐staggered binary treatments with the potential for switching in (infection) and out of treatment (recovery) within the sample period. The outcome evolution of
Mohammad Maksudur Rahman +1 more
wiley +1 more source
Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids
Angewandte Chemie, EarlyView.Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar +2 more
wiley +2 more sources