Results 261 to 270 of about 9,828,326 (308)
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Seminars in Oncology, 2002
HER2/neu is a compelling cancer vaccine candidate because it is overexpressed on some cancer cells relative to normal tissues, it is known to be immunogenic in both animal models and in humans, and it is already known to be targetable by the antibody component of the immune system in the form of monoclonal antibody therapy with trastuzumab.
Teresa M, Foy +5 more
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HER2/neu is a compelling cancer vaccine candidate because it is overexpressed on some cancer cells relative to normal tissues, it is known to be immunogenic in both animal models and in humans, and it is already known to be targetable by the antibody component of the immune system in the form of monoclonal antibody therapy with trastuzumab.
Teresa M, Foy +5 more
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Journal of Hospital Infection, 1991
Vaccination is one of the major preventive measures against infectious diseases. With the exception of the hepatitis B vaccine, the vaccines in use today are produced from the infectious agents themselves, either by attenuation or inactivation. Although these products have been successful in controlling many diseases, there are several reasons why ...
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Vaccination is one of the major preventive measures against infectious diseases. With the exception of the hepatitis B vaccine, the vaccines in use today are produced from the infectious agents themselves, either by attenuation or inactivation. Although these products have been successful in controlling many diseases, there are several reasons why ...
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Design of hepatitis A vaccines
British Medical Bulletin, 1990Hepatitis A is a major public health problem in many rapidly developing countries and it is still an important disease in many developed countries. Isolation of the virus in cell culture and access to reliable animal models has led to the development of several candidate vaccines.
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Revisiting the Principles of Designing a Vaccine
2021Immune principles formulated by Jenner, Pasteur, and early immunologists served as fundamental propositions for vaccine discovery against many dreadful pathogens. However, decisive success in the form of an efficacious vaccine still eludes for diseases such as tuberculosis, leishmaniasis, and trypanosomiasis. Several antileishmanial vaccine trials have
Shubhranshu, Zutshi +3 more
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2002
Several hemorrhagic fevers, including Lassa fever (LF; Lassa virus), Argentinian hemorrhagic fever (AHF; Junin virus), Bolivian hemorrhagic fever (BHF; Machupo virus) and Venezuelan hemorrhagic fever (VHF; Guanarito virus) are caused by arenaviruses. These diseases can be devastating, and often lethal. LCMV, the prototype of the Arenaviridae, can cause
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Several hemorrhagic fevers, including Lassa fever (LF; Lassa virus), Argentinian hemorrhagic fever (AHF; Junin virus), Bolivian hemorrhagic fever (BHF; Machupo virus) and Venezuelan hemorrhagic fever (VHF; Guanarito virus) are caused by arenaviruses. These diseases can be devastating, and often lethal. LCMV, the prototype of the Arenaviridae, can cause
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DNA Vaccines — Designer Vaccines for the 21st Century
New England Journal of Medicine, 1999Over the past 100 years, the development and widespread use of vaccines against infectious agents has been one of the triumphs of medical science.
R A, Seder, S, Gurunathan
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2006
The purpose of this chapter is to present basic strategies for the construction of DNA vaccines. This chapter discusses considerations relevant to the selection of a target gene, construction of a DNA expression vector for use as a vaccine, and molecular modifications of the vector to improve protein expression and to augment immunogenicity.
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The purpose of this chapter is to present basic strategies for the construction of DNA vaccines. This chapter discusses considerations relevant to the selection of a target gene, construction of a DNA expression vector for use as a vaccine, and molecular modifications of the vector to improve protein expression and to augment immunogenicity.
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DCs as targets for vaccine design
Cytotherapy, 2004The increasingly stringent requirements laid down by regulatory authorities have brought to an end the largely empirical design of vaccines. Vaccines must now be designed rationally, in order that appropriate immune responses are elicited with few or no side effects.
Belz, Gabrielle T. +4 more
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Design of peptide and polypeptide vaccines
Current Opinion in Biotechnology, 1997Advances have been made in the development of vaccines based on synthetic peptides and polypeptides representing tumor-associated antigens and protective epitopes of viruses and parasites. Advances within the past year include the design of vaccines based on artificial proteins, for example multiantigen peptides, branched polypeptides, fusion and ...
T, Ben-Yedidia, R, Arnon
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Molecular Structure and Vaccine Design
Annual Review of Biophysics and Biophysical Chemistry, 1990CONTENTS PERSPECTIVES AND OVERVIEW • . . . . . .... 70 The Molecules: a Brief Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 Two Strategies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
S, Vajda +5 more
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