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An ingenious design for peptide vaccines
Vaccine, 2005For humoral immunization, it may be possible to make effective and safe peptide vaccines for various diseases by selection of proper B-cell epitopes. However, a lack of T-cell epitopes on short peptides, such as those associated with major histocompatibility complex (MHC)-restriction, is a major problem for peptide vaccine development.
Akira, Yano +6 more
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Biomimetic design in microparticulate vaccines
Biomaterials, 2003Current efforts to improve the effectiveness of microparticle vaccines include incorporating biomimetic features into the particles. Many pathogens use surface molecules to target specific cell types in the gut for host invasion. This observation has inspired efforts to chemically conjugate cell-type targeting ligands to the surfaces of microparticles ...
Mark E, Keegan +2 more
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Regulatory Considerations in Vaccine Design
1995To summarize, vaccines are regulated in the United States as biologics by CBER and must meet requirements for safety, purity, and potency (efficacy). Although general requirements exist for safety, purity, and potency, specific standards for each vaccine are agreed to by the manufacturer and CBER. The final standards for any vaccine are relevant to the
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Structure-Based and Rational Design of a Hepatitis C Virus Vaccine
Viruses, 2021Johnathan Guest, Brian Pierce
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An evaluation of a test-negative design for EV-71 vaccine from a randomized controlled trial
Human Vaccines and Immunotherapeutics, 2021Feng-Cai Zhu, Jingxin Li, Pengfei Jin
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