Results 301 to 310 of about 26,123,489 (353)

Epitope-based vaccine design: a comprehensive overview of bioinformatics approaches.

Drug Discovery Today, 2020
Computational epitope-based vaccine design is the cornerstone of vaccine development. Owing to the selection of proper compositions [antigens (Ags), epitopes, peptide linkers, and intramolecular adjuvants], epitope-based vaccines are considered a cost ...
Sepideh Parvizpour, M. Pourseif, J. Razmara, M. Rafi, Y. Omidi   +4 more
semanticscholar   +1 more source

Designing HER2 vaccines

Seminars in Oncology, 2002
HER2/neu is a compelling cancer vaccine candidate because it is overexpressed on some cancer cells relative to normal tissues, it is known to be immunogenic in both animal models and in humans, and it is already known to be targetable by the antibody component of the immune system in the form of monoclonal antibody therapy with trastuzumab.
Teresa M, Foy, Gary R, Fanger, Susan, Hand, Catherine, Gerard, Claudine, Bruck, Martin A, Cheever   +5 more
openaire   +2 more sources

Vaccine design and development: Exploring the interface with computational biology and AI

International Reviews of Immunology
Computational biology involves applying computer science and informatics techniques in biology to understand complex biological data. It allows us to collect, connect, and analyze biological data at a large scale and build predictive models.
Ananya, Darshan C. Panchariya, A. Karthic, S. P. Singh, Ashutosh Mani, A. Chawade, Sandeep Kushwaha   +6 more
semanticscholar   +1 more source

An overview of in silico vaccine design against different pathogens and cancer

Expert Review of Vaccines, 2020
Introduction Due to overcome the hardness of the vaccine design, computational vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing analysis, antigenicity analysis, population coverage, conservancy analysis ...
Kimia Kardani, A. Bolhassani, A. Namvar
semanticscholar   +1 more source

Design of hepatitis A vaccines

British Medical Bulletin, 1990
Hepatitis A is a major public health problem in many rapidly developing countries and it is still an important disease in many developed countries. Isolation of the virus in cell culture and access to reliable animal models has led to the development of several candidate vaccines.
openaire   +2 more sources

A proof of concept for structure-based vaccine design targeting RSV in humans

Science, 2019
Building a better RSV vaccine Respiratory syncytial virus (RSV) causes severe respiratory disease, especially in infants and the elderly. However, attempts to produce effective human vaccines have largely been unsuccessful.
M. Crank, T. Ruckwardt, Man Chen, Kaitlyn M. Morabito, E. Phung, Pamela J. M. Costner, Lasonji Holman, S. Hickman, N. Berkowitz, Ingelise J. Gordon, G. Yamshchikov, M. Gaudinski, Azad Kumar, L. Chang, S. Moin, Juliane P. Hill, A. DiPiazza, Richard M. Schwartz, Lisa A. Kueltzo, J. Cooper, Pei-Feng Chen, J. Stein, K. Carlton, J. Gall, M. Nason, P. Kwong, Grace L. Chen, J. Mascola, J. McLellan, J. Ledgerwood, B. Graham   +30 more
semanticscholar   +1 more source

Designing future vaccines

Journal of Hospital Infection, 1991
Vaccination is one of the major preventive measures against infectious diseases. With the exception of the hepatitis B vaccine, the vaccines in use today are produced from the infectious agents themselves, either by attenuation or inactivation. Although these products have been successful in controlling many diseases, there are several reasons why ...
openaire   +2 more sources

The combination of artificial intelligence and systems biology for intelligent vaccine design

Expert Opinion on Drug Discovery, 2020
Introduction A new body of evidence depicts the applications of artificial intelligence and systems biology in vaccine design and development. The combination of both approaches shall revolutionize healthcare, accelerating clinical trial processes and ...
Giulia Russo, P. Reche, M. Pennisi, F. Pappalardo   +3 more
semanticscholar   +1 more source

Designing Arenaviral Vaccines

2002
Several hemorrhagic fevers, including Lassa fever (LF; Lassa virus), Argentinian hemorrhagic fever (AHF; Junin virus), Bolivian hemorrhagic fever (BHF; Machupo virus) and Venezuelan hemorrhagic fever (VHF; Guanarito virus) are caused by arenaviruses. These diseases can be devastating, and often lethal. LCMV, the prototype of the Arenaviridae, can cause
openaire   +2 more sources

DNA Vaccines — Designer Vaccines for the 21st Century

New England Journal of Medicine, 1999
Over the past 100 years, the development and widespread use of vaccines against infectious agents has been one of the triumphs of medical science.
R A, Seder, S, Gurunathan
openaire   +2 more sources