Results 181 to 190 of about 435,241 (348)

Microbiota Influences Vaccine and Mucosal Adjuvant Efficacy [PDF]

, 2017
Yun‐Gi Kim
openalex   +1 more source

Multi-Omics Analysis Reveals Sex-Specific Signatures for BCG Vaccine Efficacy. [PDF]

Eur J Immunol
Zhan Q, Zhou L, Fu J, Jiang X, Liu X, Li W, Moorlag SJCFM, Koeken VACM, de Bree LCJ, Mourits VP, Joosten LAB, Li Y, Netea MG, Xu CJ.   +13 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

The endemic dilemma: why whole sporozoite malaria vaccine efficacy falls in the field. [PDF]

Trends Parasitol
Hassert M, Harty JT.
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Efficacy of Vaccination [PDF]

BMJ
openaire   +2 more sources

From Crisis to Control: A Study of Typhoid Conjugate Vaccine Efficacy in Harare, Zimbabwe (2017-2024). [PDF]

Open Forum Infect Dis
Bvochora T, Manyara J, Thilliez G, Vere M, Mukeredzi I, Nhamo D, Chitiyo F, Muzondo A, Juru A, Chonzi P, Phiri I, Smith AM, Chaibva BV, Mapingure M, Fuller W, Shrestha P, Nair P, Kingsley RA, Laxminarayan R, Musuka G, Mashe T.   +20 more
europepmc   +1 more source

“More” Artificial mRNAs: Beyond the Art of Nature

Advanced Science, EarlyView.
Inspired by nature yet transcending it, synthetic mRNA is being redesigned beyond the canonical architecture. This review highlights emerging forms—circular, branched, and self‐amplifying mRNAs—that expand stability, persistence, and functional control, illustrating how artificial mRNA is evolving into a new medium for programmable biological ...
Yuanzhe Cui, Minami Fukui, Hirohisa Ohno, Hirohide Saito   +3 more
wiley   +1 more source

Association between COVID-19 vaccine efficacy and epidemic force of infection. [PDF]

NPJ Vaccines
Xu J, Halloran ME, Moore M, Zhang L, Hyrien O, Luedtke A, El Sahly HM, Baden LR, Goepfert PA, Gray G, Grinsztejn B, Sobieszczyk ME, Falsey AR, Robinson ST, Garcia NMG, Zhou H, van Dromme I, Truyers C, Hirsch I, Neuzil KM, Corey L, Kublin JG, Follmann D, Janes HE, Gilbert PB, Huang Y.   +25 more
europepmc   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, EarlyView.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source