Results 61 to 70 of about 2,076,500 (256)

Advancing usability of an influenza hemagglutinin virus-like particle vaccine expressing a chimeric cytokine

Virology Journal, 2023
Vaccine efficacy of conventional influenza vaccines depend on the antigenic similarity between the selected vaccine strain and annual epidemic strain. Since the influenza virus evolves yearly, a vaccine which is independent from viral antigenic mutation ...
Toshifumi Imagawa, Youta Arasaki, Kenichi Maegawa, Shigeo Sugita, Kuniaki Nerome   +4 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

The use of a computerized database to monitor vaccine safety in Viet Nam. [PDF]

, 2005
Health information systems to monitor vaccine safety are used in industrialized countries to detect adverse medical events related to vaccinations or to prove the safety of vaccines. There are no such information systems in the developing world, but they
Ali, Mohammad, Canh, Gia Do, Park, Jin-Kyung, Minh, Tan Truong, Clemens, John D, Thiem, Dinh Vu, von Seidlein, Lorenz, Tho, Huu Le, Vaccine Safety Datalink Group, Trach, Duc Dang   +9 more
core   +4 more sources

Estimating vaccine efficacy during open-label follow-up of COVID-19 vaccine trials based on population-level surveillance data

Epidemics
While rapid development and roll out of COVID-19 vaccines is necessary in a pandemic, the process limits the ability of clinical trials to assess longer-term vaccine efficacy. We leveraged COVID-19 surveillance data in the U.S.
Mia Moore, Yifan Zhu, Ian Hirsch, Tom White, Robert C. Reiner, Ryan M. Barber, David Pigott, James K. Collins, Serena Santoni, Magdalena E. Sobieszczyk, Holly Janes   +10 more
doaj   +1 more source

Was EU’s COVID-19 vaccine procurement strategy irrational? A re-analysis based on cost-effectiveness considerations

BMC Health Services Research, 2022
Aim The European Union (EU) has received criticism for being slow to secure coronavirus disease (COVID-19) vaccine contracts in 2020 before the approval of the first COVID-19 vaccine.
Afschin Gandjour
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Malaria immunology and vaccine development

, 2008
This thesis describes work undertaken by the author at the University of Oxford. Itbegins by providing an introduction to malaria infection and pathophysiology, anda review of the latest attempts to produce an effective malaria vaccine.
Thompson, Fiona Mary
core   +1 more source

When Vaccine Uncertainty Prevails: Association Between Online Social Influence and COVID-19 Vaccine Intentions

International Journal of Communication, 2022
Guided by the integrative model of behavioral prediction and the social identity of deindividuation effects model, this study used an online experiment (N = 322) to test a moderated-mediation model that linked exposure to user comments posted to COVID ...
Hue Trong Duong, Tham Thi Nguyen, Le Thanh Trieu   +2 more
doaj  

Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient care. [PDF]

, 2011
BACKGROUND\ud \ud An effective malaria vaccine, deployed in conjunction with other malaria interventions, is likely to substantially reduce the malaria burden. Efficacy against severe malaria will be a key driver for decisions on implementation.
Amanda Leach, Bejon, P, Walter Otieno, Kabore, W, Solange Soulanoudjingar, Njuguna, Patricia, Daniel Ansong, Kwaku Asante, Sacarlal, J, Soulanoudjingar, Solange, Ansong, D, Greenwood, Brian, Leach, Amanda, Samwel Gesase, Gesase, Samwel, Schellenberg, D, Patricia Njuguna, Bejon, Philip, Evans, Jennifer, Greenwood, B, Ansong, Daniel, Asante, KP, Clinical Trials Partnership Committee, null null, Mary J Hamel, Leach, A, Hamel, Mary J, Salim, N, Jennifer Evans, Jahit Sacarlal, Sacarlal, Jahit, Njuguna, P, Kwaku Poku Asante, Schellenberg, David, Kamthunzi, P, Gesase, S, Kevin Marsh, Asante, Kwaku Poku, Hamel, MJ, Evans, J, Portia Kamthunzi, Vekemans, J, Brian Greenwood, Vekemans, Johan, Philip Bejon, Kamthunzi, Portia, Marsh, K, Otieno, Walter, David Schellenberg, Nahya Salim, William Kabore, Otieno, W, Kabore, William, Salim, Nahya, Soulanoudjingar, S, Marsh, Kevin, Johan Vekemans   +56 more
core   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source