Results 81 to 90 of about 2,076,500 (256)

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

A meta-analysis on the effectiveness of serotype O foot-and-mouth disease vaccines

Scientific Reports
Foot-and-mouth disease (FMD) is a highly contagious viral disease of domesticated animals that causes major economic losses globally. In this meta-analysis, 29 studies were evaluated using a random-effects model to analyze the efficacy of FMD vaccines ...
Jiao Jiao, Haihua Yang, Zhenqi Liang, Yanhui Pan, Jiaxin Yang, Wenli Zhang, Peng Wu   +6 more
doaj   +1 more source

Mathematical modeling for estimating influenza vaccine efficacy: A case study of the Valencian Community, Spain.

Infectious Disease Modelling
Vaccine efficacy and its quantification is a crucial concept for the proper design of public health vaccination policies. In this work we proposed a mathematical model to estimate the efficacy of the influenza vaccine in a real-word scenario.
Carlos Andreu-Vilarroig, Rafael J. Villanueva, Gilberto González-Parra   +2 more
doaj   +1 more source

Efficacy, immunogenicity and safety of the AS04‐HPV‐16/18 vaccine in Chinese women aged 18‐25 years: End‐of‐study results from a phase II/III, randomised, controlled trial

Cancer Medicine, 2019
Background Cervical cancer is a major public health concern in China. We report the end‐of‐study results of a phase II/III trial to assess the efficacy, immunogenicity, and safety of the AS04‐human papillomavirus (HPV)‐16/18 vaccine in Chinese women aged
Feng‐Cai Zhu, Shang‐Ying Hu, Ying Hong, Yue‐Mei Hu, Xun Zhang, Yi‐Ju Zhang, Qin‐Jing Pan, Wen‐Hua Zhang, Fang‐Hui Zhao, Cheng‐Fu Zhang, Xiaoping Yang, Jia‐Xi Yu, Jiahong Zhu, Yejiang Zhu, Feng Chen, Qian Zhang, Hong Wang, Changrong Wang, Jun Bi, Shiyin Xue, Lingling Shen, Yan‐Shu Zhang, Yunkun He, Haiwen Tang, Naveen Karkada, Pemmaraju Suryakiran, Dan Bi, Frank Struyf   +27 more
doaj   +1 more source

Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths. [PDF]

, 2011
Vaccines against human helminths are being developed but the choice of optimal parasitological endpoints and effect measures to assess their efficacy has received little attention. Assuming negative binomial distributions for the parasite counts, we rank
Bethony, Jeffrey M., Hotez, Peter Jay, Brooker, Simon, Bethony, Jeffrey M, Bonnie Cundill, Neal Alexander, Hotez, Peter, Sabatelli, Lorenzo, Laura C. Rodrigues, Simon Brooker, Cundill, Bonnie, Smith, Peter G, Peter G. Smith, David Diemert, Diemert, David, Lorenzo Sabatelli, Alexander, Neal, Jeffrey M. Bethony, Peter Hotez, Bethony, Jeffrey Michael, Rodrigues, Laura C., Rodrigues, Laura C, Smith, Peter G.   +22 more
core   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Determinants of personal demand for an AIDS vaccine in Uganda: contingent valuation survey

Bulletin of the World Health Organization, 2004
OBJECTIVE: To assess the factors affecting demand for an HIV/AIDS vaccine among adults in their prime earning and childbearing years and the impact of vaccination on risk behaviour in a high-prevalence, low-income country. METHODS: A contingent valuation
David Bishai, George Pariyo, Martha Ainsworth, Kenneth Hill   +3 more
doaj  

Country of origin effects in explaining motivations for COVID-19 vaccine acceptance: A cognitive-affective-norm approach

Heliyon
This study aims to broaden the understanding of the motivational factors influencing vaccine acceptance framed as product country image (PCI) by exploring the role of overall country image (OCI), vaccine knowledge and information inconsistency, in ...
Svein Ottar Olsen, Ho Huy Tuu
doaj   +1 more source

Primary and booster immune responses to SA14-14-2 Japanese encephalitis vaccine in Korean infants

, 1999
Attenuated SA14-14-2 Japanese encephalitis (JE) vaccine has been administered safely and effectively to more than 100 million children in China since 1988 and recently, licensure of the vaccine in Korea has been sought.
박민수
core   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, EarlyView.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source