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Microbiology Spectrum, 2023 The Coronavirus disease 2019 (COVID-19) pandemic presented the scientific community with an immediate need for accurate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serology assays, resulting in an expansion of assay development, some ...
Troy J. Kemp +6 more
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Preparation and Immune Effect of HEV ORF2 P206@PLGA Nanoparticles
Nanomaterials, 2022 The hepatitis E virus (HEV) is an important pathogen that threatens global public health. One-third of the world’s population lives in the epidemic area of HEV, causing 20 million infections and 70,000 deaths annually.
Yifei Yang +5 more
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Frontiers in Immunology, 2023 IntroductionTuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a major global health threat. The only available vaccine Bacille Calmette-Guérin (BCG) does not prevent adult pulmonary TB. New effective TB vaccines should aim to stimulate
Natalie M. Kirk +10 more
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Mucosal immunity and vaccines [PDF]
Nature Medicine, 2005 There is currently great interest in developing mucosal vaccines against a variety of microbial pathogens. Mucosally induced tolerance also seems to be a promising form of immunomodulation for treating certain autoimmune diseases and allergies. Here we review the properties of the mucosal immune system and discuss advances in the development of mucosal
Jan, Holmgren, Cecil, Czerkinsky
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Serological Immunity to Smallpox in New South Wales, Australia
Viruses, 2020 The re-emergence of smallpox is an increasing and legitimate concern due to advances in synthetic biology. Vaccination programs against smallpox using the vaccinia virus vaccine ceased with the eradication of smallpox and, unlike many other countries ...
Valentina Costantino +5 more
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Frontiers in Immunology, 2022 Coronavirus disease 2019 (COVID-19) vaccines effectively elicit humoral and cellular immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in healthy populations. This immunity decreases several months after vaccination.
Michal Podrazil +8 more
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Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
Nature Communications, 2023 Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, the capacity of peripheral vaccination to generate sustained immunity in the lung mucosa, and how this is influenced by ...
Elena Mitsi +19 more
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Mucosal immunity and vaccination [PDF]
FEMS Microbiology Letters, 1991 The gut mucosal immune system is a critical component of the body's defense against pathogenic organisms, especially those responsible for enteric infections associated with diarrhoeal disease. Attempts to vaccinate against infections of mucosal tissues have been less successful than vaccination against systemic infections, to a large extent reflecting
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Scientific Reports, 2020 Cytotoxic CD8+ T cells are key for immune protection against viral infections. The breadth and cross-reactivity of these responses are important against rapidly mutating RNA viruses, such as dengue (DENV), yet how viral diversity affect T cell responses ...
Thiruni N. Adikari +7 more
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Innate immune regulation in HIV latency models
Retrovirology, 2022 Background Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 + T cells. Despite these defenses, some acutely infected cells silence viral transcription to become latently infected and form the
Rebecca M. Olson +8 more
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