Results 151 to 160 of about 82,320 (302)

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Potent monoclonal antibodies against multidrug‐resistant hypervirulent Klebsiella pneumoniae

Interdisciplinary Medicine, EarlyView.
A novel immunization strategy using a low‐virulence, multidrug‐resistant strain yields synergistic monoclonal antibodies against hypervirulent Klebsiella pneumoniae. These antibodies provide cross‐serotype protection through a dual‐mechanism of pathogen clearance and immunomodulation, offering a promising non‐antibiotic therapeutic for resistant ...
Yushan Jiang, Zhuolin Li, Yang Yang, Zihan He, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Qing Zhu, Weiling Wu, Wei Zhao, Chenguang Shen, Shi Ouyang   +10 more
wiley   +1 more source

Innovations, Challenges, and Future Prospects for Combination Vaccines Against Human Infections

Combination vaccines provide the versatile benefits of addressing different pathogens simultaneously using a combined formulation. This approach can be regarded as a substantial modernization in immunization.
Munazza Fatima, Kee-Jong Hong
core   +1 more source

Tiny carriers, big impact: How Fusobacterium nucleatum extracellular vesicles drive oral diseases and beyond

Interdisciplinary Medicine, EarlyView.
This review explores how Fusobacterium nucleatum extracellular vesicles drive local oral diseases and distal pathologies via sophisticated cross‐compartment cross talk. It highlights the transformative potential of these “tiny carriers” as next‐generation molecular intermediaries for advanced health monitoring and innovative bio‐interventions by ...
Rongyang Ma, Jiahui Huang, Yitong Chen, Haoxuan Wang, Hang Zou, Wanghong Zhao, Zilong Deng   +6 more
wiley   +1 more source

Nanomaterial-based vaccines: An advanced approach against rotavirus: A review article. [PDF]

Hum Vaccin Immunother
Soroush Fard A, Kalantar K, Teimoori A, Barati M, Arezumand R, Fani M.   +5 more
europepmc   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Live attenuated varicella vaccines in patients treated with tumor necrosis factor-alpha inhibitors: A clinical trial. [PDF]

Medicine (Baltimore)
Kamei K, Ogura M, Takeuchi I, Shimizu H, Arai K, Shoji K, Kawai T, Miyairi I, Murashima A, Ogimi C.   +9 more
europepmc   +1 more source

PROTAC vaccine: A new way to live attenuated vaccines

Clinical and Translational Medicine, 2022
Zhen Li, Haiqing Bai, Xuetong Xi, Wen‐xia Tian, John Z.H. Zhang, Demin Zhou, Longlong Si   +6 more
openaire   +3 more sources

HSV-replication defective based vector as vaccines against Rotavirus infections

, 2011
Background: Rotaviruses (RVs) are the most important cause of acute gastroenteritis in humans and animals. These viruses cause diarrheal disease primarily in the young, but infection and disease in older children and adults can occur, resulting in more ...
Facciolo, Sabrina
core  

Prevention of Myc‐Driven Prostate Cancer in Mice by Oral Administration of Sulforaphane

Molecular Carcinogenesis, EarlyView.
ABSTRACT Prevention is desirable to reduce suffering and death from prostate cancer. However, a clinical‐grade intervention for the prevention of this malignancy is still lacking. This study was undertaken to determine the feasibility of prostate cancer prevention by broccoli constituent sulforaphane (SFN) because epidemiological studies have suggested
Krishna B. Singh, Eun‐Ryeong Hahm, Bruce L. Jacobs, Shivendra V. Singh   +3 more
wiley   +1 more source