Live Attenuated Vaccines against Tuberculosis: Targeting the Disruption of Genes Encoding the Secretory Proteins of Mycobacteria [PDF]
VaccinesTuberculosis (TB), a chronic infectious disease affecting humans, causes over 1.3 million deaths per year throughout the world. The current preventive vaccine BCG provides protection against childhood TB, but it fails to protect against pulmonary TB ...
Raja Veerapandian +3 more
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PROTAC vaccine: A new way to live attenuated vaccines [PDF]
Clinical and Translational Medicine, 2022 Zhen Li +6 more
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Rational Design of Live-Attenuated Vaccines against Herpes Simplex Viruses [PDF]
Viruses, 2021 Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect millions of people worldwide and range from fatal encephalitis in neonates and herpes keratitis to orofacial and genital herpes, among other manifestations.
Brent A. Stanfield +3 more
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Engineering live attenuated vaccines: Old dogs learning new tricks [PDF]
Journal of Translational Autoimmunity, 2023 Autoimmune diseases such as rheumatoid arthritis and type 1 diabetes are increasingly common global problems. Concerns about increases in the prevalence of such diseases and the limited efficacy of conventional treatment regimens necessitates new ...
Julia Plocica +7 more
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Live-Attenuated Vaccines in Pediatric Solid Organ Transplant [PDF]
VaccinesMeasles, mumps, rubella (MMR), and varicella incidence rates have increased due to the delayed vaccination schedules of children secondary to the COVID-19 pandemic. Decreased herd immunity creates a risk for immunocompetent children and immunocompromised
Christopher Hartley +3 more
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Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions [PDF]
Advanced ScienceViral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the
Yan‐Dong Tang +3 more
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Preclinical and clinical experience with dupilumab on the correlates of live attenuated vaccines [PDF]
J Allergy Clin Immunol Glob, 2021 Michael E. Wechsler +15 more
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Synthetic biology-inspired development of live attenuated influenza vaccines
npj VaccinesLive attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns.
Qisi Zhang +14 more
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Current efforts towards safe and effective live attenuated vaccines against African swine fever: challenges and prospects [PDF]
Infect Dis Poverty, 2021 Tao Wang +3 more
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Development of Live-Attenuated Influenza Vaccines against Outbreaks of H5N1 Influenza
Viruses, 2012 Several global outbreaks of highly pathogenic avian influenza (HPAI) H5N1 virus have increased the urgency of developing effective and safe vaccines against H5N1.
Yinglei Yi, Dan Zheng, Ze Chen
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