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Rational Design of Live-Attenuated Vaccines against Herpes Simplex Viruses [PDF]

Viruses, 2021
Diseases caused by human herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) affect millions of people worldwide and range from fatal encephalitis in neonates and herpes keratitis to orofacial and genital herpes, among other manifestations.
Brent A. Stanfield, Konstantin G. Kousoulas, Agustin Fernandez, Edward Gershburg   +3 more
doaj   +5 more sources

Live Attenuated Vaccines against Tuberculosis: Targeting the Disruption of Genes Encoding the Secretory Proteins of Mycobacteria [PDF]

Vaccines
Tuberculosis (TB), a chronic infectious disease affecting humans, causes over 1.3 million deaths per year throughout the world. The current preventive vaccine BCG provides protection against childhood TB, but it fails to protect against pulmonary TB ...
Raja Veerapandian, Shrikanth S. Gadad, Chinnaswamy Jagannath, Subramanian Dhandayuthapani   +3 more
doaj   +5 more sources

Live-Attenuated Vaccines in Pediatric Solid Organ Transplant [PDF]

Vaccines
Measles, mumps, rubella (MMR), and varicella incidence rates have increased due to the delayed vaccination schedules of children secondary to the COVID-19 pandemic. Decreased herd immunity creates a risk for immunocompetent children and immunocompromised
Christopher Hartley, Tina Thomas, Sara Kathryn Smith, Wikrom Karnsakul   +3 more
doaj   +3 more sources

Engineering live attenuated vaccines: Old dogs learning new tricks [PDF]

Journal of Translational Autoimmunity, 2023
Autoimmune diseases such as rheumatoid arthritis and type 1 diabetes are increasingly common global problems. Concerns about increases in the prevalence of such diseases and the limited efficacy of conventional treatment regimens necessitates new ...
Julia Plocica, Fengguang Guo, Jugal Kishore Das, Koichi S. Kobayashi, Thomas A. Ficht, Robert C. Alaniz, Jianxun Song, Paul de Figueiredo   +7 more
doaj   +2 more sources

Viral Live‐Attenuated Vaccines (LAVs): Past and Future Directions [PDF]

Advanced Science
Viral infections continue to pose a significant threat to the health of both humans and animals. Currently, live attenuated vaccines (LAVs) remain the most efficacious and widely utilized tool for combating viral infections. Conventional LAVs involve the
Yan‐Dong Tang, Yuming Li, Xue‐Hui Cai, Xin Yin   +3 more
doaj   +2 more sources

Synthetic biology-inspired development of live attenuated influenza vaccines

npj Vaccines
Live attenuated influenza vaccines (LAIVs) provide robust, cross-protective immunity but have traditionally been developed empirically and are associated with safety concerns.
Qisi Zhang, Jiahui Cheng, Jihuan Hou, Yinlei Su, Le Li, Le Tong, Jing Li, Quan Shen, Zihao Wang, Minqi Wu, Zhen Li, Qikai Wang, Yunfei Zhang, Rui Sun, Longlong Si   +14 more
doaj   +2 more sources

PROTAC vaccine: A new way to live attenuated vaccines [PDF]

Clinical and Translational Medicine, 2022
Zhen Li, Haiqing Bai, Xuetong Xi, Wen‐xia Tian, John Z.H. Zhang, Demin Zhou, Longlong Si   +6 more
doaj   +2 more sources

Development of Live-Attenuated Influenza Vaccines against Outbreaks of H5N1 Influenza

Viruses, 2012
Several global outbreaks of highly pathogenic avian influenza (HPAI) H5N1 virus have increased the urgency of developing effective and safe vaccines against H5N1.
Yinglei Yi, Dan Zheng, Ze Chen
doaj   +3 more sources

Prevention and Control of Porcine Epidemic Diarrhea: The Development of Recombination-Resistant Live Attenuated Vaccines [PDF]

Viruses, 2022
Chun-Ming Lin, Qiuhong Wang
exaly   +2 more sources

Quality control procedure for Coccidial vaccines versus different routes of immunization [PDF]

Veterinary World, 2022
Background and Aim: Coccidiosis is an enteric infection caused by a protozoon (Eimeria tenella). Coccidiosis is known to have a negative impact on the economy. Coccidiosis is controlled using anticoccidial drugs, antibiotics, and vaccines.
Arwa Elnaggar, Hala Mahmoud, Sahar Saber
doaj   +1 more source