Results 161 to 170 of about 1,398,780 (286)

Development of Live-Attenuated Arenavirus Vaccines Based on Codon Deoptimization

Journal of Virology, 2015
B. Y. H. Cheng, Emilio Ortiz-Riaño, A. Nogales, J. C. de la Torre, L. Martínez-Sobrido   +4 more
semanticscholar   +1 more source

Advancing dengue vaccine development: Challenges, innovations, and the path toward global protection

Pediatric Investigation, EarlyView.
Dengue vaccine development faces challenges, including antibody‐dependent enhancement and serotype‐specific immunity. This review highlights licensed vaccines, CYD‐TDV, TAK‐003, and Butantan‐DV, and explores strategies for achieving effective multivalent protection.
Ran Wang, Bridget Kim, Hridesh Mishra, Kevin C. Kain   +3 more
wiley   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Micro‐ and nanomotors in biomedical applications

Responsive Materials, EarlyView.
Micro‐ and nanomotors (MNMs), as autonomous devices converting chemical or external energy into mechanical propulsion, have emerged as transformative drug delivery platforms in biomedicine. This review systematically outlines the design principles governing MNMs' propulsion and operation, highlights the applications of MNMs in disease treatment, and ...
Xiangyu Meng, Yuqi Tang, Quan Li
wiley   +1 more source

A Promising Attenuated Rhabdovirus Vaccine Candidate Conferring Dual-Route Protection Against MSRV Disease in Largemouth Bass (<i>Micropterus salmoides</i>). [PDF]

Vaccines (Basel)
Fu X, Li W, Kong M, Liang H, Lin Q, Niu Y, Luo X, Ma B, Zhou J, Li N.   +9 more
europepmc   +1 more source

Balancing allocative and dynamic efficiency with redundant R&D allocation: The role of organizational proximity and centralization

Strategic Management Journal, EarlyView.
Abstract Research Summary Resource‐based‐view scholars have mainly examined two resource allocation approaches for competitive advantage in multiunit firms: resource sharing and resource redeployment. These approaches emphasize allocative efficiency—the optimal allocation of resources to maximize their current value. In technology‐intensive industries,
Vivek Tandon, Anand Nandkumar, Ronak Mogra, Kannan Srikanth   +3 more
wiley   +1 more source

Pathogenicity and virulence of Powassan virus. [PDF]

Virulence
Kaur M, Adam M, Mladinich MC.
europepmc   +1 more source

Nasal Delivery of mRNA Using Thermoresponsive Gellable Aqueous Biphasic Systems

Small, EarlyView.
Nasal delivery of mRNA using gellable aqueous biphasic systems (ABS) represents a noninvasive alternative while reducing the need for trained professionals and cold chain storage. Composed of gelatin, PEG, and water, these thermoresponsive hydrogels ensure controlled mRNA delivery and prolonged retention at the nasal mucosa, improving transfection ...
Bojan Kopilovic, Nabila Laroui, João A.P. Coutinho, Chantal Pichon, Mara G. Freire   +4 more
wiley   +1 more source

Biological threat preparedness through vaccine development and stockpiling: challenges and strategic implications. [PDF]

Front Public Health
Lee J.
europepmc   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source