Results 101 to 110 of about 16,296 (221)

GRP78 Nanobody‐Directed Immunotoxin Activates Innate Immunity Through STING Pathway to Synergize Tumor Immunotherapy

Advanced Science, EarlyView.
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang, Runhua Zhou, Chengchao Xu, Lingyun Dai, Rui Hou, Liuhai Zheng, Chunjin Fu, Guangwei Shi, Jingwei Wang, Yang Li, Jinpeng Cen, Xiaolong Xu, Le Yu, Yilei Li, Jigang Wang, Qingfeng Du, Zhijie Li   +16 more
wiley   +1 more source

Progress towards the development of Klebsiella vaccines

Expert Review of Vaccines, 2019
Introduction: Klebsiella pneumoniae (KP) are a leading cause of healthcare-associated infections. The dramatic increase in microbial resistance to third-generation cephalosporin and carbapenem ‘front line’ antimicrobial agents and the paucity of new ...
Myeongjin Choi, Sharon M Tennant, Raphael Simon, Alan S Cross   +3 more
doaj   +1 more source

A Three Component Synthetic Vaccine Containing a β-Mannan T-Cell Peptide Epitope and a β-Glucan Dendritic Cell Ligand

Molecules, 2018
Glycoconjugates prepared from the capsular polysaccharide of several pathogenic bacteria and carrier proteins, such as CRM 197 or tetanus toxoid, have been one of the most successful public health measures to be implemented in the last quarter century. A
David R. Bundle, Eugenia Paszkiewicz, Hassan R. H. Elsaidi, Satadru Sekhar Mandal, Susmita Sarkar   +4 more
doaj   +1 more source

Polyplex Nanomicelle‐Mediated Pgc‐1α4 mRNA Delivery Via Hydrodynamic Limb Vein Injection Enhances Damage Resistance in Duchenne Muscular Dystrophy Mice

Advanced Science, EarlyView.
This study presents a novel approach for treating Duchenne muscular dystrophy using mRNA encoding PGC‐1α4. Nanomicelle‐delivered Pgc‐1α4 mRNA enhances muscle damage resistance and mitochondrial activity in dystrophic muscles. This study demonstrates the potential of mRNA therapy for neuromuscular diseases like Duchenne muscular dystrophy and highlights
Xuan Du, Hideyuki Nakanishi, Takashi Yamada, Yooksil Sin, Katsura Minegishi, Norio Motohashi, Yoshitsugu Aoki, Keiji Itaka   +7 more
wiley   +1 more source

Immunogenicity and Efficacy of Different Haemophilus influenzae type b Vaccines

Archives of Razi Institute, 2014
Haemophilus influenzae, a major cause of meningitis in young children leading to death and other neurological sequelae. The disease leaves 15 to 35% of the survivors with permanent disabilities, such as, mental retardation or deafness.
Mojgani, N.
doaj  

Design of a Glycoconjugate Vaccine Against Salmonella Paratyphi A

Vaccines
Background/Objectives: Typhoid and paratyphoid fever together are responsible for millions of cases and thousands of deaths per year, most of which occur in children in South and Southeast Asia.
Renzo Alfini, Martina Carducci, Luisa Massai, Daniele De Simone, Marco Mariti, Omar Rossi, Simona Rondini, Francesca Micoli, Carlo Giannelli   +8 more
doaj   +1 more source

Current safety issues with quadrivalent meningococcal conjugate vaccines

Human Vaccines & Immunotherapeutics, 2018
Invasive meningococcal disease, although rare, can present as sudden, life-threatening disease with high risk of mortality or severe long-term sequelae.
Tanya R. Myers, Michael M. McNeil
doaj   +1 more source

An evaluation of emerging vaccines for childhood meningococcal disease

BMC Public Health, 2011
Background Meningococcal meningitis is a major cause of disease worldwide, with frequent epidemics particularly affecting an area of sub-Saharan Africa known as the “meningitis belt”.
Nelson Christopher B, El Arifeen Shams, Zhang Jian Shayne F, Johnson Hope L, Luksic Ivana, Falconer Rachel, Zgaga Lina, Nair Harish, Theodoratou Evropi, Huda Tanvir, Choudhuri Debajeet, Borrow Ray, Campbell Harry, Rudan Igor   +13 more
doaj   +1 more source

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Social Imitation Dynamics of Vaccination Driven by Vaccine Effectiveness and Beliefs [PDF]

arXiv
Declines in vaccination coverage for vaccine-preventable diseases, such as measles and chickenpox, have enabled their surprising comebacks and pose significant public health challenges in the wake of growing vaccine hesitancy. Vaccine opt-outs and refusals are often fueled by beliefs concerning perceptions of vaccine effectiveness and exaggerated risks.
arxiv