Results 121 to 130 of about 1,048,296 (327)

Monitoring the introduction of pneumococcal conjugate vaccines into West Africa: design and implementation of a population-based surveillance system. [PDF]

, 2012
Routine use of pneumococcal conjugate vaccines (PCVs) in developing countries is expected to lead to a significant reduction in childhood deaths. However, PCVs have been associated with replacement disease with non-vaccine serotypes.
Adegbola, Richard A, Akinsola, Bolanle, Baldeh, Ignatius, Greenwood, Brian M, Hill, Philip C, Howie, Stephen RC, Ikumapayi, Usman N, Jasseh, Momodou, Knoll, Maria Deloria, Lee, Ellen, Levine, Orin S, Mackenzie, Grant A, Plumb, Ian D, Saha, Debasish, Sambou, Sana, Touray, Kebba, Uchendu, Uchendu, Usuf, Effua, Wattiaux, Andre   +18 more
core   +2 more sources

Pneumococcal Conjugate and Plain Polysaccharide Vaccines Have Divergent Effects on Antigen-Specific B Cells

Journal of Infectious Diseases, 2012
Background. A 23-valent unconjugated pneumococcal polysaccharide vaccine (23vP), routinely administered at the age of 65, has limited effectiveness, and revaccination induces attenuated antibody responses.
E. Clutterbuck, R. Lazarus, Ly-Mee Yu, J. Bowman, E. Bateman, L. Diggle, B. Angus, T. Peto, P. Beverley, D. Mant, A. Pollard   +10 more
semanticscholar   +1 more source

Geometric Adjustment of T Cell‐Sensitive Nanorobots for Enhanced Stability

Advanced Healthcare Materials, EarlyView.
For the long‐term use of live dendritic cell (DC)‐based vaccines, nano bone marrow dendritic cell (BMDC) originated T cell activators (nano‐BOTs) are synthesized. The geometric properties of nanoparticles are precisely modulated, enhancing their stability and T cell activation capacity.
Yoojin Lee, Dahae Kim, Taihyun Kim, Chae‐Won Moon, Hyungseok Yong, Sung‐eun Heo, Bumgyu Choi, Yoogyeong Oh, Woojin Choi, Kyungtae Park, Sang‐Jun Ha, Jinkee Hong   +11 more
wiley   +1 more source

Serotypes and susceptibility of Streptococcus pneumoniae strains isolated from children in Mexico Serotipos y susceptibilidad de cepas de Streptococcus pneumoniae aisladas de niños en México

Salud Pública de México, 2008
Objective. To identify serotypes and susceptibility of S. pneumoniae strains from 48 children with invasive infections and 50 carriers. Material and Methods.
Alberto Villaseñor-Sierra, Maricarmen Lomas-Bautista, Sergio Aguilar-Benavides, Gerardo Martínez-Aguilar   +3 more
doaj  

Bacterial outer membrane vesicles and vaccine applications [PDF]

, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo, Acosta, Armando, Campa, Concepcion, Cardoso, Daniel, Fernandez, Sonsire, Ferro, Valerie, Garcia, Luis, Perez, Jose Luis, Rosenqvist, Einar, Sarmiento, Maria Elena, Zayas, Caridad   +10 more
core   +2 more sources

Rational Design of Unsaturated, Thioether Ionizable Lipids for Enhanced In Vivo mRNA Delivery

Advanced Healthcare Materials, EarlyView.
Lipid nanoparticles (LNPs) have rapidly become the delivery system of choice for RNA therapeutics. Here, a rational design approach is taken to improve the effectiveness of LNPs based on an ionizable thioether lipid library. The incorporation of unsaturated tails and bulkier, hydrophobic head groups significantly enhances their functionality and ...
Eleni Samaridou, Johanna Simon, Moritz Beck‐Broichsitter, Gary Davidson, Pavel A. Levkin   +4 more
wiley   +1 more source

Beyond good intentions: lessons on equipment donation from an African hospital. [PDF]

, 2008
OBJECTIVE: In 2000, a referral hospital in the Gambia accepted a donation of oxygen concentrators to help maintain oxygen supplies. The concentrators broke down and were put into storage.
Adegbola, Richard A, Hill, Philip C, Hill, Sarah E, Howie, Stephen RC, Mulholland, Kim, Njie, Malick, Peel, David, Sanneh, Momodou   +7 more
core   +2 more sources

Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting

Advanced Materials, EarlyView.
CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu, Won Joon Kim, Hyunjin Lee, Xiaoping Bao, Pilnam Kim   +4 more
wiley   +1 more source

Immunization Update, April 2008, Vol. 1, no. 7 [PDF]

, 2008
Monthly newsletter for the Iowa Department of Public ...

core  

Seasonality and outbreak of a predominant Streptococcus pneumoniae serotype 1 clone from The Gambia: expansion of ST217 hypervirulent clonal complex in West Africa. [PDF]

, 2008
BACKGROUND: Streptococcus pneumoniae serotype 1 causes > 20% of invasive disease, among all age groups combined, in The Gambia. In contrast, it is rarely detected in carriage studies. This study compares the molecular epidemiology of S.
Adegbola, Richard A, Akisanya, Abiodun, Antonio, Martin, Awine, Timothy, Corrah, Tumani, Cutts, Felicity, Egere, Uzochukwu, Enwere, Godwin, Greenwood, Brian M, Hakeem, Ishrat, Hill, Philip C, Lahai, George, Nsekpong, David, Sankareh, Kawsu, Secka, Ousman, Zaman, Syed MA   +15 more
core   +2 more sources