Results 131 to 140 of about 16,296 (221)

Structural and Biochemical Characterization of a Widespread Enterobacterial Peroxidase Encapsulin

Advanced Science, EarlyView.
Encapsulins are self‐assembling bacterial protein compartments loaded with cargo enzymes. The most abundant encapsulin cargo class are Dye‐decolorizing Peroxidases (DyPs). In this study, we structurally and biochemically characterize a DyP encapsulin found in many enterobacteria.
Natalia C. Ubilla‐Rodriguez, Michael P. Andreas, Tobias W. Giessen   +2 more
wiley   +1 more source

Chemically Enhanced Immunogenicity of Bacteria by Supramolecular Functionalization with an Adjuvant

ChemBioChem, Volume 23, Issue 23, December 5, 2022., 2022
Poorly immunogenic pathogens are a major cause of infectious disease. We chemically modified the surface of such a pathogen (Staphylococcus aureus) with a synthetic adjuvant to boost immunogenicity. “Adjuvanted” S. aureus induced improved immune responses in macrophages compared to unadulterated bacteria.
Nikolas Duszenko, Danny M. van Willigen, Anton Bunschoten, Aldrik H. Velders, Meta Roestenberg, Fijs W. B. van Leeuwen   +5 more
wiley   +1 more source

Las vacunas conjugadas contra la enfermedad meningococica causadas por los serogrupos A, C, W-135, Y

VacciMonitor, 2009
Review the current evidence on available and candidate quadrivalent meningococcal conjugate vaccines. Methods: A comprehensive overview of data on the currently available A-C-W135-Y meningococcal vaccine and the results of late stage development of novel
Marcos Aurelio P. Sáfadi
doaj  

Viridicatol from the Deep‐Sea‐Derived Fungus Alleviates Bone Loss by Targeting the Wnt/SHN3 Pathway

Advanced Science, EarlyView.
Viridicatol (VDC), isolated from the deep‐sea‐derived fungus, enhances osteogenesis in vitro and in vivo by targeting Wnt/SHN3 signaling pathway. It can be delivered via engineered nanovesicles to mitigate bone loss of osteoporosis, fracture repair, and osteogenesis imperfecta.
Chun‐Lan Xie, Shang‐Hui Ye, Yu‐Ting Yue, Bao‐Hong Shi, Jing‐Ping Xu, Lian‐Jie Li, Zheng‐Biao Zou, Matthew B. Greenblatt, Na Li, Xian‐Wen Yang, Ren Xu   +10 more
wiley   +1 more source

Mitigating Cellular Dysfunction Through Contaminant Reduction in Synthetic circRNA for High‐Efficiency mRNA‐Based Cell Reprogramming

Advanced Science, EarlyView.
This study addresses the challenges of synthetic circular RNAimpurities that trigger immune responses and hinder efficacy. Key immunogenic byproducts are identified and develop a multi‐step purification process that produces ultra‐pure circRNA and enhances yields by over 10‐fold.
Ziwei Zhang, Weiyu Li, Xiangyu Ren, Dengwang Luo, Xiushuang Yuan, Li Yu, Daming Wang, Yuhong Cao   +7 more
wiley   +1 more source

Understanding PFOS Adsorption on a Pt Electrode for Electrochemical Sensing Applications

ChemElectroChem, Volume 10, Issue 2, January 17, 2023., 2023
Electrochemical Detection of Per‐Fluoro Octane Sulfonate: The adsorption dynamic of PFOS molecule on a metal electrode depends on its concentration – at low concentration, random orientation of adsorption is observed; at medium concentration, PFOS molecule is aligned due to adsorbate‐adsorbate interaction. At high concentration, multiplayers of PFOS is
Pratahdeep Gogoi, Yu Yao, Yuguang C. Li
wiley   +1 more source

Natural Enzyme‐Loaded Polymeric Stealth Coating‐Armed Engineered Probiotics by Disrupting Tumor Lactate Homeostasis to Synergistic Metabolism‐Immuno‐Enzyme Dynamic Therapy

Advanced Science, EarlyView.
Engineered Lactobacillus acidophilus (LH@LA) is developed via in situ polymerization to co‐load lactate oxidase (LOx) and horseradish peroxidase (HRP). This system preserves LA activity, evades macrophage phagocytosis, and synergizes LA metabolism with enzyme cascades to enhance immunity, reduce tumor ATP, suppress PD‐L1 expression and AKT‐mTOR ...
Liuzhou Mao, Bahriman Xarpidin, Rui Shi, Yuting Lin, Haohua Hu, Caisheng Wu, Zheng Luo, Yun‐Long Wu   +7 more
wiley   +1 more source

Hydrophilic Chitosan Derivatives: Synthesis and Applications

Chemistry – A European Journal, Volume 28, Issue 67, December 1, 2022., 2022
A benign and low‐cost alternative for fossil‐fuel‐sourced polymers, chitosan has tremendous potential because of its bioactivity, biocompatibility, biodegradability, and low toxicity. Synthetic pathways for chitosan derivatives with improved water solubility, and their associated applications, are explored. With the change in global direction towards a
Erez Cohen, Elena Poverenov
wiley   +1 more source

Pneumoccocal conjugate vaccines [PDF]

International Journal of Infectious Diseases, 2016
openaire   +2 more sources

Targeting Antigen‐Presenting Cells to Enhance the Tumor‐Spleen Immunity Cycle through Liposome‐Neoantigen Vaccine

Advanced Science, EarlyView.
LNPsD18, a cationic liposome that enhances antigen‐presenting cell uptake in the spleen and tumor without targeting ligands is developed. Co‐delivering neoantigens and a TLR9 agonist significantly improve DC activation, tumor immunity, and survival in liver and colorectal cancer models, demonstrating the importance of dual‐site APC targeting for cancer
Yu Xu, Bing Wang, Yue Huang, JianPing Liao, Chenyi Wu, Chenxi Zhou, Zishi Kang, Shiyang Jiang, Bing‐Chen Wu, Da Zhang, Ruihua Xu, Xiaolong Liu, Feng Wang   +12 more
wiley   +1 more source