Results 21 to 30 of about 1,023,792 (288)

A review of complement sources used in serum bactericidal assays for evaluating immune responses to meningococcal ACWY conjugate vaccines

Human Vaccines & Immunotherapeutics, 2019
Invasive meningococcal disease is rare and potentially devastating but often vaccine-preventable. Evaluation of meningococcal vaccine effectiveness is impractical owing to relatively low disease incidence; protection is therefore estimated using serum ...
J. Findlow, P. Balmer, R. Borrow
semanticscholar   +1 more source

Relationship between immune response to pneumococcal conjugate vaccines in infants and indirect protection after vaccine implementation

Expert Review of Vaccines, 2019
Introduction: Streptococcus pneumoniae is a leading cause of morbidity and mortality worldwide. Widespread infant vaccination with pneumococcal conjugate vaccines (PCVs) substantially reduced vaccine-serotype pneumococcal disease by direct protection of ...
R. Dagan
semanticscholar   +1 more source

Progress toward the global control of Neisseria meningitidis: 21st century vaccines, current guidelines, and challenges for future vaccine development

Human Vaccines & Immunotherapeutics, 2018
The control of meningitis, meningococcemia and other infections caused by Neisseria meningitidis is a significant global health challenge. Substantial progress has occurred in the last twenty years in meningococcal vaccine development and global ...
A. W. Dretler, N. G. Rouphael, D. S. Stephens   +2 more
doaj   +1 more source

Extensively Drug-Resistant Typhoid - Are Conjugate Vaccines Arriving Just in Time?

New England Journal of Medicine, 2018
Extensively Drug-Resistant Typhoid More than 1000 cases of XDR Salmonella Typhi have been confirmed in Pakistan. Until recently, vaccines against typhoid have had limited efficacy and durability of immunogenicity, but an effective conjugate vaccine is ...
J. Andrews, F. Qamar, R. Charles, E. Ryan   +3 more
semanticscholar   +1 more source

Effectiveness of pneumococcal conjugate vaccines against invasive pneumococcal disease among children under five years of age in Africa: A systematic review

PLoS ONE, 2019
Background Despite the widespread implementation of the pneumococcal conjugate vaccine, Streptococcus pneumoniae remains the leading cause of severe pneumonia associated with mortality among children less than 5 years of age worldwide, with the highest ...
J. Ngocho, Best Magoma, Gaudencia Alois Olomi, M. Mahande, S. Msuya, M. D. de Jonge, B. Mmbaga   +6 more
semanticscholar   +1 more source

ANTIGENIC ACTIVITY ASSAYS OF EXPERIMENTAL CONJUGATE VACCINES BASED ON SYNTHETIC OLIGOSACCHARIDE LIGANDS AND CRM197 CARRIER PROTEIN

Медицинская иммунология, 2017
So far, there is no effective treatment for a number of socially significant bacterial and fungal diseases. β-(1→3) glucans are polysaccharides consisting of glucose units linked together with β-(1→3)- glycoside bonds.
E. G. Bogomolova, O. A. Dodrovolskaya, E. A. Fedorova, A. M. Kondrashkina, N. N. Kolmakov, S. A. Ishchuk, I. V. Dukhovlinov, A. S. Simbirtsev   +7 more
doaj   +1 more source

Comparison of Strategies and Incidence Thresholds for Vi Conjugate Vaccines Against Typhoid Fever: A Cost-effectiveness Modeling Study

Journal of Infectious Diseases, 2018
Background Typhoid fever remains a major public health problem globally. While new Vi conjugate vaccines hold promise for averting disease, the optimal programmatic delivery remains unclear.
N. Lo, Ribhav Gupta, J. Stanaway, D. Garrett, I. Bogoch, S. Luby, J. Andrews   +6 more
semanticscholar   +1 more source

Design and production of conjugate vaccines against S. Paratyphi A using an O-linked glycosylation system in vivo

npj Vaccines, 2018
Enteric fever, mainly caused by Salmonella enterica serovar Paratyphi A, remains a common and serious infectious disease worldwide. As yet, there are no licensed vaccines against S. Paratyphi A.
Peng Sun, Chao Pan, Ming Zeng, Bo Liu, Haoyu Liang, Dongshu Wang, Xiankai Liu, Bin Wang, Yufei Lyu, Jun Wu, Li Zhu, Hengliang Wang   +11 more
semanticscholar   +1 more source

Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques

npj Vaccines, 2023
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date have suggested the need to increase the durability and functionality of vaccine-elicited antibodies to improve efficacy.
Danielle Nettere, Shakthi Unnithan, Nicole Rodgers, Junsuke Nohara, Paul Cray, Madison Berry, Caroline Jones, Lawrence Armand, Shuk Hang Li, Stella J. Berendam, Genevieve G. Fouda, Derek W. Cain, Taylor N. Spence, Joshua A. Granek, Clemontina A. Davenport, Robert J. Edwards, Kevin Wiehe, Koen K. A. Van Rompay, M. Anthony Moody, Sallie R. Permar, Justin Pollara   +20 more
doaj   +1 more source

Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach

Chemical Reviews, 2021
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and parasitic pathogens. Recognition of these unique glycans by the human immune system results in destruction of the invaders.
P. Seeberger
semanticscholar   +1 more source