Results 41 to 50 of about 1,048,296 (327)

ERA OF CONJUGATE VACCINES: INTERNATIONAL EXPERIENCE OF SUCCESSFUL APPLICATION

Педиатрическая фармакология, 2008
The article highlights comparative characteristics of the polysaccharide and conjugate vaccines against pneumococcal infection, meningococcosis and haemophilus influenza. The author stresses the advantage of the conjugate vaccines.
M.V. Fedoseenko, M.G. Galitskaya, L.S. Namazova   +2 more
doaj   +2 more sources

Production of glycoprotein vaccines in Escherichia coli

Microbial Cell Factories, 2010
Background Conjugate vaccines in which polysaccharide antigens are covalently linked to carrier proteins belong to the most effective and safest vaccines against bacterial pathogens.
Ihssen Julian, Kowarik Michael, Dilettoso Sandro, Tanner Cyril, Wacker Michael, Thöny-Meyer Linda   +5 more
doaj   +1 more source

Immunogenicity and safety of MenACWY-TT, a quadrivalent meningococcal tetanus toxoid conjugate vaccine recently licensed in the United States for individuals ≥2 years of age

Human Vaccines & Immunotherapeutics, 2022
Vaccination offers the best way to prevent invasive meningococcal disease (IMD). As demonstrated in countries with national immunization programs (NIPs) against IMD, meningococcal conjugate vaccines have contributed to significant declines in incidence ...
Gary S. Marshall, Stephen I. Pelton, Corwin A. Robertson, Philipp Oster   +3 more
doaj   +1 more source

Impact of Pneumococcal Conjugate Vaccines on Pneumonia Hospitalizations in High- and Low-Income Subpopulations in Brazil. [PDF]

, 2017
BackgroundPneumococcal conjugate vaccines (PCVs) are being used worldwide. A key question is whether the impact of PCVs on pneumonia is similar in low- and high-income populations.
Kürüm, Esra, Lustig, Roger, Schuck-Paim, Cynthia, Shioda, Kayoko, Simonsen, Lone, Taylor, Robert J, Warren, Joshua L, Weinberger, Daniel M   +7 more
core   +2 more sources

Impact of protein D-containing pneumococcal conjugate vaccines on non-typeable Haemophilus influenzae acute otitis media and carriage

Expert Review of Vaccines, 2017
Introduction: Protein D-containing vaccines may decrease acute otitis media (AOM) burden and nasopharyngeal carriage of non-typeable Haemophilus influenzae (NTHi).
Christopher Clarke, L. Bakaletz, J. Ruiz-Guiñazú, D. Borys, T. Mrkvan   +4 more
semanticscholar   +1 more source

Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach

Chemical Reviews, 2021
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and parasitic pathogens. Recognition of these unique glycans by the human immune system results in destruction of the invaders.
P. Seeberger
semanticscholar   +1 more source

Biosynthesis of Conjugate Vaccines Using an O-Linked Glycosylation System

mBio, 2016
Conjugate vaccines are known to be one of the most effective and safest types of vaccines against bacterial pathogens. Previously, vaccine biosynthesis has been performed by using N-linked glycosylation systems.
Chao Pan, Peng Sun, Bo Liu, Haoyu Liang, Zhehui Peng, Yan Dong, Dongshu Wang, Xiankai Liu, Bin Wang, Ming Zeng, Jun Wu, Li Zhu, Hengliang Wang   +12 more
semanticscholar   +1 more source

Conjugate vaccines

Expert Review of Vaccines, 2003
Conjugate vaccines in which the capsular polysaccharide of Haemophilus influenzae type b, common serotypes of Streptococcus pneumoniae and group C Neisseria meningitidis are covalently bound to a protein antigen to convert a T-cell-independent immune response into a T-cell-dependent response have proved highly effective in the prevention of invasive ...
openaire   +2 more sources

Evolution of conjugate vaccines

Expert Review of Vaccines, 2002
Conjugate vaccines--bacterial polysaccharides conjugated to proteins to improve their immunizing properties--have been a success story since their introduction less than 20 years ago. The Haemophilus influenzae type b conjugate vaccine has nearly eliminated invasive Haemophilus influenzae type b disease in large parts of the world.
P. Helena Mäkelä, Helena Käyhty
openaire   +3 more sources

Glycolipid‐peptide conjugate vaccines elicit CD8+ T‐cell responses and prevent breast cancer metastasis

Clinical & Translational Immunology, 2022
Objectives Metastasis is the principal cause of breast cancer mortality. Vaccines targeting breast cancer antigens have yet to demonstrate clinical efficacy, and there remains an unmet need for safe and effective treatment to reduce the risk of ...
Olivia K Burn, Kathryn Farrand, Tara Pritchard, Sarah Draper, Ching‐wen Tang, Anna H Mooney, Alfonso J Schmidt, Sung H Yang, Geoffrey M Williams, Margaret A Brimble, Matheswaran Kandasamy, Andrew J Marshall, Kate Clarke, Gavin F Painter, Ian F Hermans, Robert Weinkove   +15 more
doaj   +1 more source