Results 191 to 200 of about 471,639 (303)

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Exceeding expectations: factors contributing to the potency of human papillomavirus vaccines. [PDF]

Lancet Microbe
Schiller JT, Kines RC, Day PM, Çuburu N, Kreimer AR, Lowy DR.   +5 more
europepmc   +1 more source

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response—A Randomized, Placebo‐Controlled Trial

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1049-1056, October 2026.
Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used by solid organ transplant recipients. Although it is known that MMF suppresses immune responses, its exact effects on specific vaccinations have not been investigated yet. Mucosal vaccinations are increasingly used, such as a cholera vaccination consisting of two oral immunizations ...
Boukje C. Eveleens Maarse, Aliede E. in 't Veld, Hendrika W. Grievink, Manon A.A. Jansen, Matthijs Moerland   +4 more
wiley   +1 more source

Extracellular vesicles as new-age vaccine carriers: a focused account on viral diseases. [PDF]

Front Immunol
Rajput R, Khanna M, Radhika, Sharma J, Kaur H.   +4 more
europepmc   +1 more source

Targeting the PI3K/Akt Signaling Pathway: A Promising Therapeutic Strategy to Reduce Cancer Mortality and Overcome Chemoresistance

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims The phosphatidylinositol 3‐kinase (PI3K)/Akt signaling pathway is a central regulator of cellular properties that are essential for cancer progression, including cellular growth, survival, metabolism, and angiogenesis. Dysregulated PI3K/Akt signaling, often caused by genetic alterations in PIK3CA, loss of PTEN, or the ...
Md Mohiuddin
wiley   +1 more source

Preclinical immunogenicity and safety evaluation of MDCK cell-derived quadrivalent influenza virus subunit vaccine. [PDF]

Front Immunol
Li S, Lv J, Li X, Yang Y, Yan Y, Sui L, Wu Y.   +6 more
europepmc   +1 more source

Characterization of carABpyrB operon and role of pyrE in Francisella novicida biofilm

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Pyrimidine biosynthesis links metabolism to biofilm regulation in Francisella novicida. During nutrient limitation, reduced pyrimidine availability shifts metabolism from uracil salvage to de novo synthesis, increasing biofilm formation. Mutants in carABpyrB exhibit uracil‐dependent growth defects and elevated biofilm:growth ratios, revealing ...
Katie C. Sprinkel, Annika R. Geiger, Monique L. van Hoek   +2 more
wiley   +1 more source

Update on efficacy, safety, and immunogenicity of Dengue vaccines: a systematic review and meta-analysis. [PDF]

Infez Med
Zaçe D, Çekrezi A, Leone M, Ciarpaglini S, Montagnari G, Giacalone ML, Diforti S, Rodriguez-Morales AJ, Iannetta M, Sarmati L.   +9 more
europepmc   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Evaluation of immune protective efficacy of recombinant subunit vaccines based on Eimeria tenella EtAMA1 and EtSAG13. [PDF]

Poult Sci
Zhu S, Wang H, Liu Y, Gao H, Lv C, Kang S, Cui X, Lv X, Li J, Bai R.   +9 more
europepmc   +1 more source